Utility of serum lipid ratios for predicting incident type 2 diabetes: the Isfahan Diabetes Prevention Study

Abstract

TG/HDL and TC/HDL ratios were not robust predictors of T2D in high-risk individuals in Iran. Copyright © 2015 John Wiley & Sons, Ltd.

Association between the ratio of triglyceride to high‐density lipoprotein cholesterol and incident type 2 diabetes in Singapore Chinese men and women

“…Our finding of a positive association between the TG: HDL‐C ratio and T2D risk is supported by previous studies in Chinese, Iranian, Japanese, and Caucasian men, despite the heterogeneity in statistical methods (studies modeled the TG: HDL‐C ratio as either a continuous variable, a binary variable with a cut‐off point, or in quartiles). However, one prospective study showed a null association . That study was conducted in a group of Iranian people (without diabetes) with a family history of diabetes and participants had much higher BMI and TG: HDL‐C ratios compared with subjects in the present study (mean BMI 29 vs 23 kg/m 2 , respectively; TG: HDL‐C ratio 4.0 vs 1.3, respectively); therefore, the TG: HDL‐C ratio may not predict T2D risk in this specific high‐risk population.…”

“…So far, only a few prospective studies have examined this issue, and the extent to which the TG: HDL‐C ratio is independently related to T2D risk has been variable. Some studies found a positive association, whereas one study showed a null association . Moreover, few studies have explored whether the association is modified by gender and fasting status .…”

“…5 Although recent studies demonstrated that the TG: HDL-C ratio could be a better predictor of insulin resistance and cardiovascular disease (CVD) than TG or HDL-C alone, 6,7 the association between the TG: HDL-C ratio and T2D is not entirely clear as yet. So far, only a few prospective studies have examined this issue, [8][9][10][11][12][13] and the extent to which the TG: HDL-C ratio is independently related to T2D risk has been variable. Some studies found a positive association, [8][9][10][11][12] whereas one study showed a null association.…”

The nonlinear association between apolipoprotein B to apolipoprotein A1 ratio and type 2 diabetes

“…[1,2] Given the high prevalence of type 2 diabetes and its complications, investigating its etiology, exploring the most modifiable risk factors, and searching for the predictive clinical parameters are of extreme importance for type 2 diabetes prevention and treatment. [3–5] Apolipoproteins are the primary structural proteins for lipoprotein particles. Apolipoprotein B (ApoB) is the basic apolipoprotein for low density lipoprotein cholesterol (LDL) and apolipoprotein A1 (ApoA1) is the major apolipoprotein for high density lipoprotein cholesterol (HDL).…”

“…Several previous studies suggested that the elevated ApoB to ApoA1 ratio was a more powerful parameter than other lipid fractions for metabolic disorders including type 2 diabetes. [5–9] However, these studies also assumed that the relationship between ApoB to ApoA1 ratio and type 2 diabetes risk was linear, which was seldom examined in published literatures.…”