Higher ratio of ischemic stroke to hemorrhagic stroke in summer

Shigematsu, Kazuo; Watanabe, Yoshiyuki; Nakano, Hiromi

doi:10.1111/ane.12412

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…Conversely, others found that the highest incidence and mortality of stroke occurs in summer and autumn as the warmest season of the year whereas, some studies revealed no seasonal and monthly variations in incidence and mortality of stroke. Seasonal variations among stroke subtypes have also been demonstrated by a few studies ( 6 , 9 , 10 ).…”

Section: Introductionmentioning

confidence: 77%

“…Evidence from epidemiological studies on the stroke and its subtypes have indicated association with biological ( 2 ) , physiological ( 3 ), socioeconomic status ( 4 ) and environmental factors ( 5 ). Over the last three decades, seasonal and monthly variation in the incidence and mortality stroke have been widely investigated in different geographical and climatic conditions ( 6 - 8 ). Nevertheless, findings in many cases are variable and sometimes contradictory.…”

Section: Introductionmentioning

confidence: 99%

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Seasonal and Monthly Variation in Stroke and its Subtypes-10 Year Hospital-Based Study

et al. 2017

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Background and Objectives:There is no evidence of long-term studies of seasonal variations in stroke in Iran. Hence, the aim of this study was to determine the seasonal and monthly variation of 28-day mortality in Isfahan, Iran.Methods:From 2003 to 2013, In a Hospital-based retrospective study which was conducted by Isfahan Cardiovascular Research Center(ICRC), 24186 cases with first-ever stroke were recruited. Multinomial logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for seasonal and monthly 28-day mortality for stroke in general and three subtypes of stroke including intracranial hemorrhage (ICH), ischemic (IS) and subarachnoid hemorrhage (SAH).Results:In this study, unadjusted and adjusted odds ratios of seasonal 28-day mortality of stroke was highest in the winter and lowest in the summer. Although, differences were not statistically significant. For total and IS stroke, the unadjusted 28-day mortality ratio (UMR) was significant in February (1.19, 95% CI 1.00 -1.42, P= 0.04) as compared to March. Whereas after adjusted, for total stroke, 28-day mortality was significantly lowest in May (0.746, 95% CI 0.575-0.97, p=0.029), June (0.777, 95% CI 0.60-0.99, p=0.49) and July (0.771, 95% CI 0.59-0.99 p=0.049) as compared to March. The AMR between months were not significant in SAH and IS.Conclusion:Our findings demonstrate clear obvious monthly variation of 28-day mortality of stroke and its subtypes in Isfahan but no seasonal variations were observed.

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Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Seasonal and Monthly Variation in Stroke and its Subtypes-10 Year Hospital-Based Study

et al. 2017

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“…1 A stroke is a potentially life-threatening event and a major cause of disability, the incidence of which increases with age. 3 Previous studies have reported a higher incidence of lacunar and atheromatous infarctions during the summer season relative to other seasons, [4][5][6] which may be because the dehydration caused by hot weather leads to hemoconcentration and increased blood and plasma viscosity, and could contribute to thrombosis. 7,8 Therefore, to prevent a stroke, the elderly could be advised to increase their water intake during the summer season, which is when it is easiest to become dehydrated.…”

Section: Introductionmentioning

confidence: 99%

Seasonal variation in hydration status among community‐dwelling elderly in Japan

Tanaka

Fujishiro

Watanabe

et al. 2020

Geriatrics Gerontology Int

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Aim: While the heat during the summer season may dehydrate the elderly, little is known about the seasonal variation in dehydration. This study aimed to investigate the seasonal variation in hydration status among the community-dwelling elderly in Japan. Methods: We retrospectively analyzed the data collected after an overnight fast of adults aged ≥65 years who had no advanced kidney disease and underwent an annual health checkup at Nihon University Hospital between January and December 2019. Participants were classified according to their checkup date, whether summer (n = 265) or not summer (n = 638). The not summer group was subdivided into spring (n = 235), autumn (n = 213) and winter (n = 190). Results: Among the four seasons, the spring group showed the highest levels of plasma osmolality (306.1 AE 3.9 mOsm/L), urine specific gravity (1.0172 AE 0.0058) and prevalence rates of urine specific gravity ≥1.020 (34.0%). However, seasonal differences were clinically mild, and >90% of participants showed plasma osmolality ≥300 mOsm/L, indicating dehydration, in all four seasons. The summer group showed lower urine specific gravity levels (1.0150 AE 0.0062 vs. 1.0165 AE 0.0064, P < 0.001) and prevalence rates of urine specific gravity ≥1.020 (22.6% vs. 30.4%, P = 0.023) than did the not summer group. The summer season was associated with low urine specific gravity levels even after adjusting for the multiple linear regression model. Conclusion: Japanese elderly after overnight fast are more dehydrated during the spring rather than the summer.

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“…Stroke is one of the most common neurological disorders, and is the second largest cause of death and disability worldwide. 1) Based on its pathogenesis, stroke can be classified into 2 categories: ischemic stroke and hemorrhagic stroke. Ischemic stroke results from disturbances of the cerebral circulation, while hemorrhagic stroke occurs as a result of alterations to the blood vessels in the brain, which ultimately cause intraparenchymal or subarachnoid hemorrhage.…”

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confidence: 99%

Acteoside Attenuates Oxidative Stress and Neuronal Apoptosis in Rats with Focal Cerebral Ischemia–Reperfusion Injury

Xia

Zhang

Zhao

2018

Biological & Pharmaceutical Bulletin

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Acteoside (ACT) has been shown to exert antioxidant and neuroprotective effects in neurodegenerative diseases. However, the effect of ACT on cerebral ischemia-reperfusion (I/R) injury is not yet clear. In this study, we found that ACT administration reduced infarct volume and brain edema, and improved neurological deficits, as indicated by the decreased modified neurological severity score. Administration of ACT strikingly reduced oxidative stress, accompanied by decreased levels of reactive oxygen species and malondialdehyde and increased levels of superoxide dismutase and catalase in a rat model of middle cerebral artery occlusion/reperfusion (MCAO/R). Furthermore, ACT administration reduced the number of terminal deoxynucleotidyl transferase uridine 5′-triphosphate (UTP) nick-end labeling-positive cells in the cerebral cortex of ischemic side of MCAO/R rats, accompanied by downregulation of B cell lymphoma 2 (Bcl-2) associated X protein and cleaved caspase-3 proteins and upregulation of Bcl-2 protein. Additionally, ACT treatment inhibited the protein kinase R/eukaryotic initiation factor-2α stress pathway in the brains of MCAO/R rats. Our results demonstrated that ACT attenuates oxidative stress and neuronal apoptosis in MCAO/R rats, suggesting that ACT may serve as a novel therapeutic candidate for the treatment of I/R brain injury.

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Higher ratio of ischemic stroke to hemorrhagic stroke in summer

Abstract: Seasonal variations differed among stroke subtypes. The OR for CH/CeI and for SAH/CeI was lower in summer and higher in the rest of seasons independent of age, gender, and risk factors.

Cited by 11 publications

References 29 publications

Seasonal and Monthly Variation in Stroke and its Subtypes-10 Year Hospital-Based Study

Seasonal and Monthly Variation in Stroke and its Subtypes-10 Year Hospital-Based Study

Seasonal variation in hydration status among community‐dwelling elderly in Japan

Acteoside Attenuates Oxidative Stress and Neuronal Apoptosis in Rats with Focal Cerebral Ischemia–Reperfusion Injury

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