Higher positive lymph node ratio indicates poorer distant metastasis–free survival in adenoid cystic carcinoma patients with nodal involvement

Liu, Zhonglong; Fang, Zhiwei; Dai, Tianguo; Zhang, Chenping; Sun, Jian; He, Yue

doi:10.1016/j.jcms.2015.03.040

Cited by 13 publications

(9 citation statements)

References 23 publications

(60 reference statements)

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“…ENS was not a negative prognosticator in this series as opposed to the study by Bhayani et al, although their series included relatively few patients with nodal disease. A recent report by Liu et al showed a poorer metastatic‐free survival in case of higher lymph node ratio and ENS in a relatively larger series of N+ cases of ACC (N+ n = 47; ENS+ n = 18). Larger numbers of patients are required, however, to determine the real prognostic influence of ENS in ACC.…”

Section: Discussionmentioning

confidence: 88%

Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck

et al. 2016

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Section: Discussionmentioning

confidence: 88%

Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck

et al. 2016

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“…Thus, 18 articles, all published in English, were included for further investigation. 2 , 3 , 5 , 7 , 13 – 25 The study selection procedure is illustrated by flow diagram ( Figure 1 ). In total, 18 studies involving 2993 patients were included in the analysis.…”

Section: Resultsmentioning

confidence: 99%

Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis

Ning

Zhao

Wang

et al. 2018

CMAR

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BackgroundThe purpose of this research was to determine whether neck dissection is necessary for the adenoid cystic carcinoma (ACC) of head and neck.Materials and methodsThis article screened the abstract and full-text papers that investigated salivary gland primary ACC of head and neck. Two independent reviewers searched for articles published before October 2017 in three databases (Web of Science, PubMed, and Ovid), having no limits in date and language. Statistical data were analyzed statistically by Review Manager 5.3.ResultsIn total, 18 studies involving 2993 patients were included in the analysis. Of the 2993 patients, 473 patients had cervical lymph node metastasis, with a merge frequency of 16% (95% CI: 13–19). Among included articles, only 4 involved cervical lymph node occult metastases, with a merge frequency of 14% (95% CI: 9–20). There were 5 articles containing minor salivary glands (MiSGs) involving 370 patients of which 92 patients had cervical lymph node metastases and the merge frequency was 25% (95% CI: 11–38). Moreover, there were 4 studies on major salivary glands involving 904 patients of which 158 patients had cervical lymph node metastases and the merge frequency was 17% (95% CI: 15–20).ConclusionElective neck dissection is unnecessary for all patients with salivary gland ACC of head and neck. Moreover, compared with major salivary glands, MiSGs have a higher cervical lymph node metastases rate in ACC. The overall cervical lymph node metastases rate of MiSGs is 25%, which is enough to attract our attention. Therefore, we suggest that neck dissection might be applied to ACC of MiSGs.

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“…Liu et al performed a retrospective review of 47 patients with head and neck ACC with nodal involvement. 10 All patients underwent neck dissection. They found that positive lymph node ratio was predictive of overall survival and metastasis-free survival.…”

Section: Discussionmentioning

confidence: 99%

Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma

Megwalu

Sirjani

2017

Otolaryngol.--head neck surg.

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Objective To determine the risk of nodal metastasis, examine risk factors for nodal metastasis, and evaluate the impact of nodal metastasis on survival in patients with major salivary gland adenoid cystic carcinoma. Study Design Retrospective cohort study from a large population- based cancer database. Methods Data were extracted from the SEER 18 database (Surveillance, Epidemiology, and End Results) of the National Cancer Institute. The study cohort included 720 patients diagnosed with major salivary gland adenoid cystic carcinoma between 1988 and 2013. Results The overall rate of lymph node metastasis was 17%. T3 disease (odds ratio, 4.74) and T4 disease (odds ratio, 9.24) were associated with increased risk of nodal metastasis. Age, sex, and site were not associated with nodal metastasis. Nodal metastasis was associated with worse overall survival (hazard ratio, 2.56) and disease-specific survival (hazard ratio, 3.27), after adjusting for T stage, presence of distant metastasis, site, surgical resection, radiotherapy, neck dissection, age, sex, race, marital status, and year of diagnosis. Conclusion Major salivary gland adenoid cystic carcinoma carries significant risk of nodal metastasis. Advanced T stage is associated with increased risk of nodal metastasis. Nodal metastasis is associated with worse survival.

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Higher positive lymph node ratio indicates poorer distant metastasis–free survival in adenoid cystic carcinoma patients with nodal involvement

Cited by 13 publications

References 23 publications

Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck

Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck

Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis

Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma

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