Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis

Ning, Chunliu; Zhao, Tengfei; Wang, Zechen; Li, Delong; Kou, Yurong; Huang, Shao Mei

doi:10.2147/cmar.s164677

Cited by 24 publications

(13 citation statements)

References 35 publications

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“…In our series, the cN þ rate at the time of diagnosis is low (11%, 48 patients). In comparison, Ning's meta-analysis finds a high variability of results (4%e33%) depending on the series, with an average of 16% of cNþ [13].…”

Section: Discussionmentioning

confidence: 95%

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Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Atallah

Moya‐Plana

Malard³

et al. 2020

European Journal of Cancer

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Background: Patterns of nodal involvement in adenoid cystic carcinoma (ACC) of the head and neck have not been sufficiently assessed to guide a decision of prophylactic neck dissection (ND). The objective of this study is to analyse the influence of ND on event-free survival (EFS) for patients with cN0 ACC. Patients and methods: A multicentre prospective study was conducted between 2009 and 2018. Patients presenting cN0 non-metastatic ACC on any site, and who received surgery on the tumour, were included. EFS was the main judgement criterion. A comparative survival analysis between the groups that received a ND versus those that did not was performed, using a propensity score. Analyses were carried out using the R software. Results: Between 2009 and 2018, 322 patients with cN0 ACC were included, out of which 58% were female. The average age was 53 years. Tumours were in minor salivary glands in 58% of cases, and 52% had T3/T4 stages.ND was performed on 46% of patients. Out of them, seven had histological lymph node invasion, out of which six had tumour infiltration in the mucosa of oral cavity.After propensity score, the median EFS for N0 patients with ND was 72 months (95% Confidence Interval (CI) [48e81]), compared to 73 months (95% CI [52e85]) for patients without ND (HR Z 1.33; 95% CI [0.82e2.16]; p Z 0.2). Conclusion: ND of cN0 patients does not provide any benefit on EFS, which suggests that its application on such patients is not necessary.

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Section: Discussionmentioning

confidence: 95%

“…Few studies present the occurrence rate of occult LNM among the cN0 after ND. It varies from 8% to 23%, with an average of 14% in Ning's meta-analysis [7,13,17,18].…”

Section: Discussionmentioning

confidence: 99%

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Atallah

Moya‐Plana

Malard³

et al. 2020

European Journal of Cancer

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“…[ 36 ] Ning et al performed a systematic review and reported that the average rate of occult metastasis in salivary gland ACC was 14%. [ 37 ] Xiao et al reviewed the United States National Cancer Database and reported that cN0 patients with ACCs in the major salivary glands and tongues had significantly increased risk of occult metastasis, and they suggested that prophylactic neck dissection is necessary for this group. [ 38 ] In contrast, a recent multi-institutional retrospective analysis in Japan showed that prophylactic neck dissection for the salivary glands ACC was not associated with better clinical outcomes in the 5 year observation periods.…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the sublingual gland developing lung metastasis 20 years after primary treatment

et al. 2021

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Rationale: Adenoid cystic carcinoma (ACC) is a rare malignant tumor that primarily occurs in the salivary glands. Distant metastases can develop despite favorable local control. Moreover, distant metastasis of ACC can occur after a long time interval without local recurrence. We report the first case of ACC of the sublingual gland that developed lung metastasis 20 years after primary treatment. Patient concerns: A 52-year-old man was referred to our department with a 1-year history of painful swelling on the right oral floor. Diagnosis: An incisional biopsy was performed, and histopathological examination revealed malignancy. Interventions: Surgical excision of the right oral floor and right supra-omohyoid neck dissection with postoperative chemoradiation therapy were performed, and ACC of the sublingual gland was diagnosed. Left pulmonary metastasis was detected 20 years after the primary treatment. Metastasectomy was performed; however, subsequently, skin and bone metastases developed. Outcomes: After receiving palliative care, the patient died of multiple organ failure. Lessons: As late distant metastasis of salivary ACC can develop, patients who undergo primary treatment need a long-term, strict follow-up plan even if locoregional control is favorable.

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“…Perineural and lymphovascular invasion, as well as extracapsular spread, are well known adverse pathological characteristics [15–18]. Walvekar et al [7] reported that high grade parotid cancer is more likely to exhibit extracapsular spread.…”

Section: Discussionmentioning

confidence: 99%

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Fang

Liu

2019

BMC Cancer

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s Background Primary parotid squamous cell carcinoma (SCC) is an uncommon tumour, and there is limited data on its prognosis and treatment. The goal of the current study was to analyse the potential prognostic factors and clinical outcomes for this tumour type. Methods Consecutive patients with surgically treated primary parotid SCC were retrospectively enrolled in this study. The primary end point was locoregional control (LRC) and disease-specific survival (DSS), which were calculated by the Kaplan-Meier method. Independent prognostic factors were evaluated by the Cox proportional hazards method. Results In total, 53 patients were included for analysis. Perineural and lymphovascular invasion were observed in 21 and 16 patients, respectively. Intraparotid node (IPN) metastasis was reported in 23 patients with an incidence rate of 43.3%. Twenty-six patients with cN0 disease underwent neck dissection, and pathologic node metastasis was observed in 10 cases. The 5-year LRC and DS S rates were 35 and 49%, respectively. The Cox model was used to report the independence of disease stage and IPN metastasis in predicting LRC and the independence of disease stage and perineural invasion in predicting DSS. Conclusions The prognosis of primary parotid SCC is relatively unfavourable. IPN metastasis significantly decreases disease control, disease stage is the most important prognostic factor, and neck dissection is suggested for patients at any stage.

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Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis

Cited by 24 publications

References 35 publications

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Adenoid cystic carcinoma of the sublingual gland developing lung metastasis 20 years after primary treatment

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

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