Higher peripheral neutrophil and monocyte counts are independent indicators of the presence and severity of proteinuria in apparently normal adults

Huang, Zei-Shung; Chen, Y.‐M.; Wu, Mai‐Szu; Chen, M.‐F.

doi:10.1111/j.1445-5994.2008.01881.x

Cited by 4 publications

(7 citation statements)

References 25 publications

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“…Nevertheless, neutrophils are also involved in numerous pathologies including tumors and tissue damage by forming neutrophil extracellular traps, secreting pro-inflammatory cytokines, releasing reactive oxygen species and damaging endothelial cells (5,6) . Consistently, previous cross-sectional studies have reported that the presence of proteinuria is significantly related to leucocyte and neutrophil counts (7)(8)(9)(10) . In addition, a prospective study has shown that elevated leucocyte counts were associated with an increased risk of proteinuria in Japanese men (11) .…”

supporting

confidence: 88%

“…Although there have been some previous cross-sectional studies that have reported inverse associations between leucocyte or neutrophil counts and proteinuria (7)(8)(9)(10) , crosssectional studies are not useful in determining temporal relations. A prospective study in Japanese men aged 40-55 years has shown that the highest quintile of leucocyte counts was associated with an increased risk of proteinuria incidence (hazard ratio 1•45, 95 % CI 1•23, 1•73) compared with the lowest quintile (11) .…”

Section: Discussionmentioning

confidence: 99%

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Interaction of neutrophil counts and folic acid treatment on new-onset proteinuria in hypertensive patients

et al. 2020

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We aimed to examine whether baseline neutrophil counts affected the risk of new-onset proteinuria in hypertensive patients, and, if so, whether folic acid treatment is particularly effective in proteinuria prevention in such a setting. A total of 8208 eligible participants without proteinuria at baseline were analysed from the renal substudy of the China Stroke Primary Prevention Trial. Participants were randomised to receive a double-blind daily treatment of 10 mg of enalapril and 0·8 mg of folic acid (n 4101) or 10 mg of enalapril only (n 4107). The primary outcome was new-onset proteinuria, defined as a urine dipstick reading of ≥1+ at the exit visit. The mean age of the participants was 59·5 (sd, 7·4) years, 3088 (37·6 %) of the participants were male. The median treatment duration was 4·4 years. In the enalapril-only group, a significantly higher risk of new-onset proteinuria was found among participants with higher neutrophil counts (quintile 5; ≥4·8 × 109/l, OR 1·44; 95 % CI 1·00, 2·06), compared with those in quintiles 1–4. For those with enalapril and folic acid treatment, compared with the enalapril-only group, the new-onset proteinuria risk was reduced from 5·2 to 2·8 % (OR 0·49; 95 % CI 0·29, 0·82) among participants with higher neutrophil counts (≥4·8 × 109/l), whereas there was no significant effect among those with neutrophil counts <4·8 × 109/l. In summary, among hypertensive patients, those with higher neutrophil counts had increased risk of new-onset proteinuria, and this risk was reduced by 51 % with folic acid treatment.

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confidence: 88%

Section: Discussionmentioning

confidence: 99%

Interaction of neutrophil counts and folic acid treatment on new-onset proteinuria in hypertensive patients

et al. 2020

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“…year Follow-up months Definition of OA for inclusion Age, years Women, % No. of patients Quality score A B C D E F G H I J K L M Amin [ 10 ] 2009 30 ACR criteria 69 42 265 13 1 1 1 1 1 1 1 1 1 1 1 1 1 Tanamas [ 35 ] 2010 24 K/L 63.2 ± 10.3 51 109 13 1 1 1 1 1 1 1 1 1 1 1 1 1 Cicuttini [ 14 ] 2004 24 K/L 63.1 ± 10.3 58 113 12 1 1 1 1 1 1 0 1 1 1 1 1 1 Hill [ 19 ] 2007 30 ACR criteria 66.7 ± 9.2 41 233 12 1 1 1 1 1 1 0 1 1 1 …”

Section: Resultsmentioning

confidence: 99%

“…Roemer et al found an association in knees with more than two subregions with bone marrow lesions (BMLs), but no association when scoring BMLs [ 32 ]. Tanamas et al investigated the association for BMLs in the tibiofemoral joint [ 35 ]. They found significant associations for the total presence of BMLs and for medial BMLs.…”

Section: Resultsmentioning

confidence: 99%

Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies

Bastick¹,

Runhaar²,

Belo³

et al. 2015

Arthritis Res Ther

135

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IntroductionWe performed a systematic review of prognostic factors for the progression of symptomatic knee osteoarthritis (OA), defined as increase in pain, decline in physical function or total joint replacement.MethodWe searched for available observational studies up to January 2015 in Medline and Embase according to a specified search strategy. Studies that fulfilled our initial inclusion criteria were assessed for methodological quality. Data were extracted and the results were pooled, or if necessary summarized according to a best evidence synthesis.ResultsOf 1,392 articles identified, 30 met the inclusion criteria and 38 determinants were investigated. Pooling was not possible due to large heterogeneity between studies. The best evidence synthesis showed strong evidence that age, ethnicity, body mass index, co-morbidity count, magnetic resonance imaging (MRI)-detected infrapatellar synovitis, joint effusion and baseline OA severity (both radiographic and clinical) are associated with clinical knee OA progression. There was moderate evidence showing that education level, vitality, pain-coping subscale resting, MRI-detected medial femorotibial cartilage loss and general bone marrow lesions are associated with clinical knee OA progression. However, evidence for the majority of determinants was limited (including knee range of motion or markers) or conflicting (including age, gender and joint line tenderness).ConclusionStrong evidence was found for multiple prognostic factors for progression of clinical knee OA. A large variety in definitions of clinical knee OA (progression) remains, which makes it impossible to summarize the evidence through meta-analyses. More research on prognostic factors for knee OA is needed using symptom progression as an outcome measure. Remarkably, only few studies have been performed using pain progression as an outcome measure. The pathophysiology of radiographic factors and their relation with symptoms should be further explored.

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“…In our study comparing PLR and NLR, there was no significant difference as a marker for proteinuria. Huang et al studied 12,225 normal healthy individuals who were called to hospital for checkup and found a significant relationship between total leukocytes, neutrophil, and monocyte counts and the presence of proteinuria but found no relation with lymphocyte counts .…”

Section: Discussionmentioning

confidence: 99%

Is Neutrophil Lymphocyte Ratio an Indicator for Proteinuria in Chronic Kidney Disease?

Binnetoğlu

Şengül²,

Halhalli³

et al. 2014

Clinical Laboratory Analysis

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Higher peripheral neutrophil and monocyte counts are independent indicators of the presence and severity of proteinuria in apparently normal adults

Cited by 4 publications

References 25 publications

Interaction of neutrophil counts and folic acid treatment on new-onset proteinuria in hypertensive patients

Interaction of neutrophil counts and folic acid treatment on new-onset proteinuria in hypertensive patients

Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies

Is Neutrophil Lymphocyte Ratio an Indicator for Proteinuria in Chronic Kidney Disease?

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