Higher levels of aggression are observed in socially dominant toadfish treated with the selective serotonin reuptake inhibitor, fluoxetine

McDonald, M. Danielle; Gonzalez, Alexander; Sloman, Katherine A.

doi:10.1016/j.cbpc.2010.09.006

Cited by 43 publications

(40 citation statements)

References 51 publications

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“…Also, the difference in mass at metamorphosis could have been caused by SSRI-induced changes in social behavior causing subordinates to reduce feeding activities. Although exposure to antidepressants has been shown to decrease aggression in some aquatic vertebrates (Perreault et al, 2003;Lynn et al, 2007), McDonald et al (2011 found that socially dominant toadfish treated with the SSRI fluoxetine exhibited higher levels of aggression toward conspecifics compared with untreated controls. Increased agonistic interactions between tadpoles maintained together could explain our finding of smaller mass at metamorphosis in tadpoles reared together in 2010 but would require further direct observation of behavior to be supported.…”

Section: Discussionmentioning

confidence: 98%

Growth Inhibition of Tadpoles Exposed to Sertraline in the Presence of Conspecifics

Carfagno

Fong

2014

Journal of Herpetology

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Section: Discussionmentioning

confidence: 98%

Growth Inhibition of Tadpoles Exposed to Sertraline in the Presence of Conspecifics

Carfagno

Fong

2014

Journal of Herpetology

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“…With the exception of reduced locomotor activity in juvenile fish (Painter et al, 2009; Winder et al, 2011), most previous studies have found that at concentrations a minimum of ten times higher than what has been documented in the aquatic environment caused increased (McDonald et al, 2010) or decreased (Kohlert et al, 2012; Barry, 2013) aggression, disruption in the endocrine axis (Lister et al 2009; Fernandes et al 2011; Mennigen et al, 2010a,b), and declines in feeding behavior (Gaworecki and Klaine, 2008) and general movement (Beulig and Fowler 2008), but no impact on reproductive output (Foran et al, 2004). In some cases lower exposure levels were not tested and in the cases where lower exposures were actually tested, these studies have not shown an impact of fluoxetine.…”

Section: Introductionmentioning

confidence: 99%

Environmental concentrations of the selective serotonin reuptake inhibitor fluoxetine impact specific behaviors involved in reproduction, feeding and predator avoidance in the fish Pimephales promelas (fathead minnow)

2014

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Pharmaceuticals and personal care products (PPCP) have been found in surface waters worldwide, but little is understood of their effects on the wildlife that inhabit these waters. Fluoxetine (Prozac; Eli Lilly), a highly prescribed selective serotonin reuptake inhibitor (SSRI), is a commonly found PPCP in surface water. The purpose of this project was to determine if environmentally relevant concentrations of fluoxetine impact behavior that is important for population survival in native fish species, including reproduction, feeding and predator avoidance. Chronic 4-week exposures were conducted with doses ranging from 100 ng/L to 100 μg/L to cover a range of environmentally relevant concentrations up to higher concentrations comparable to other published studies with the same drug that have documented various physiological impacts. Pimephales promelas (fathead minnow), a species native to North America, was used as it conducts a range of specific mating behaviors and therefore serves as an excellent model of specific impacts on brain function. Fluoxetine concentrations as low as 1 μg/L, a concentration that has been found in many freshwater environments, were found to significantly impact mating behavior, specifically nest building and defending in male fish. Males were also found to display aggression, isolation, and repetitive behaviors at higher concentrations. Female mating behavior was largely unaffected. In addition, predator avoidance behaviors in males and females were also impacted at 1 μg/L. Feeding was impacted at 10 μg/L and in the highest exposure (100 μg/L), egg production was limited by deaths of females due to significant male aggressive behaviors in first two weeks of exposure. Specific behavioral changes occurred at each concentration (most noticeably 1 μg/L and 100 μg/L) indicating a dose dependent effect that triggered different responses at lower exposures versus higher exposures or differential impacts of dose depending on brain region. Length of exposure also had an impact on aggressive behavior. Changes in hormone levels, indicating significant neuroendocrine changes, suggested as a mechanism of response in higher dose and acute studies, were not linked to changes in behaviors at the doses used in this study. This research provides detailed data on how exposures to fluoxetine impact specific fish behaviors and reproduction and that the effects are dose dependent.

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“…The reduced growth observed in this study, in the presence of sufficient food, is likely due to the fluoxetine-induced changes in behavior that were observed. Continued fluoxetine exposure changes serotonin levels in striped bass (Gaworecki and Klaine, 2008) and toadfish (McDonald et al, 2011) and affects levels of dopamine, norepinephrine, and estradiol in goldfish (Mennigen et al, 2008). It follows that behaviors resulting from these pathways would be altered in response to fluoxetine treatment.…”

Section: Discussionmentioning

confidence: 95%

Chronic exposure to environmentally-relevant concentrations of fluoxetine (Prozac) decreases survival, increases abnormal behaviors, and delays predator escape responses in guppies

Pelli

Connaughton

2015

Chemosphere

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Higher levels of aggression are observed in socially dominant toadfish treated with the selective serotonin reuptake inhibitor, fluoxetine

Cited by 43 publications

References 51 publications

Growth Inhibition of Tadpoles Exposed to Sertraline in the Presence of Conspecifics

Growth Inhibition of Tadpoles Exposed to Sertraline in the Presence of Conspecifics

Environmental concentrations of the selective serotonin reuptake inhibitor fluoxetine impact specific behaviors involved in reproduction, feeding and predator avoidance in the fish Pimephales promelas (fathead minnow)

Chronic exposure to environmentally-relevant concentrations of fluoxetine (Prozac) decreases survival, increases abnormal behaviors, and delays predator escape responses in guppies

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