Growth Inhibition of Tadpoles Exposed to Sertraline in the Presence of Conspecifics

Carfagno, Gerardo L.F.; Fong, Peter P.

doi:10.1670/13-058

Cited by 12 publications

(5 citation statements)

References 57 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our lowestobserved-effect concentration (LOEC, 0.05 pM) significantly shortened the time to metamorphosis compared with the wateronly control without affecting tadpole mass. Our mass values at metamorphosis are in agreement with those recorded in our lab by Carfagno and Fong [13] for wood frog tadpoles. Previous studies on the effects of toxicants on the timing of metamorphosis have shown reduced body mass concomitant…”

Section: Discussionsupporting

confidence: 91%

“…Thereafter, egg masses were maintained in 100% dechlorinated tap water (pH 7.5, dissolved oxygen 7.2 ppm, temperature 21 °C, conductivity 772 μS/cm) until hatching. Previous experiments have shown that these eggs and resulting tadpoles survive well in dechlorinated tap water. Hatching from all egg masses occurred spontaneously within 4 d of collection.…”

Section: Methodsmentioning

confidence: 93%

“…Potential causes for their demise have included infectious diseases, global climate change, ultraviolet (UV) radiation, and aquatic pollution [4]. In the latter case, several studies have shown clear detrimental effects on lifehistory variables by municipal effluent [5], pesticides and herbicides [6][7][8], road salt [9], fertilizers [10], heavy metals [11], and active pharmaceutical ingredients [12][13][14][15]. Among those aquatic contaminants of emerging concern [16-19], engineered nanoparticles have received a considerable amount of recent attention [20][21][22][23][24][25]; but information on their effects on amphibian life cycles is still lacking, even though the tadpole larvae are as likely as any aquatic organism to be exposed to nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long‐term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations

Fong

Thompson

Carfagno

et al. 2016

Enviro Toxic and Chemistry

Self Cite

View full text Add to dashboard Cite

Nanoparticles are environmental contaminants of emerging concern. Exposure to engineered nanoparticles has been shown to have detrimental effects on aquatic organisms. The authors synthesized gold nanoparticles (18.1 ± 3.5 nm) and tested their effects on time to and weight at metamorphosis in wood frog (Lithobates sylvaticus) tadpoles, a species known to be sensitive to environmental stressors. Continuous exposure to all concentrations of gold nanoparticles (0.05 pM, 0.5 pM, and 5 pM in particles) for up to 55 d significantly reduced time to metamorphosis by as much as an average of 3 d (p < 0.05). However, exposure to gold nanoparticles had no effect on tadpole mass at metamorphosis. The approximately 18-nm gold nanoparticles used were metastable in dechlorinated tap water, resulting in a change in surface charge and aggregation over time, leading to negatively charged aggregates that were on the order of 60 nm to 110 nm. Nanoparticle aggregation could exacerbate the effect on time to metamorphosis. To the authors' knowledge, the present study is the first report on the effect of engineered nanoparticles of any kind on life-history variables in an amphibian, a taxonomic group that has been declining globally for at least 25 yr. Environ Toxicol Chem 2016;35:2304-2310. © 2016 SETAC.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long‐term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations

Fong

Thompson

Carfagno

et al. 2016

Enviro Toxic and Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the exposed animals, this pattern was missing, which can affect the reproductive success in a population due to a higher risk of predation. Life history traits and affected reproduction have also been confirmed from other studies with several psychoactive drugs on different aquatic taxa [36,43,48].…”

Section: Discussionsupporting

confidence: 67%

Oxazepam Alters the Behavior of Crayfish at Diluted Concentrations, Venlafaxine Does Not

Kubec

Hossain

Grabicová

et al. 2019

Water

View full text Add to dashboard Cite

Pharmaceutically active compounds are only partially removed from wastewaters and hence may be major contaminants of freshwaters. Direct and indirect effects on aquatic organisms are reported at dilute concentrations. This study was focused on the possible effects of environmentally relevant concentrations (~1 µg L−1) of two psychoactive compounds on the behavior of freshwater crayfish. Experimental animals exposed to venlafaxine did not show any behavioral alteration. Crayfish exposed to the benzodiazepine oxazepam exhibited a significant alteration in the distance moved and activity, and the effects were different when individuals were ready for reproduction. Results suggested that even the low concentration of selected psychoactive pharmaceuticals could alter the behavioral patterns of crayfish, as reported for other pharmaceuticals. These results provide new information about the possible adverse effects of pharmaceuticals at dilute concentrations. From previous knowledge and our results, it is obvious that different compounds have different effects and the effects are even specific for different taxa. Detailed studies are therefore needed to assess the possible ecological consequences of particular substances, as well as for their mixtures.

show abstract

“…Eggs were maintained in pond water for 2 d, then transferred to a 50:50 mixture of pond water:dechlorinated tap water (for 1 d, and finally to dechlorinated tap water thereafter; Stress Coat dechlorinator; Aquarium Pharmaceuticals). Dechlorinated tap water (pH 7.5, dissolved oxygen 7.2 ppm, temperature 21 °C, conductivity 772 μS/cm) has been used in laboratory experiments with anuran tadpoles with success . Eggs from at least 6 different egg masses began to hatch 4 d after collection.…”

Section: Methodsmentioning

confidence: 99%

Differential uptake of gold nanoparticles by 2 species of tadpole, the wood frog (Lithobates sylvaticus) and the bullfrog (Lithobates catesbeianus)

Thompson

Carfagno

Andresen

et al. 2017

Enviro Toxic and Chemistry

Self Cite

View full text Add to dashboard Cite

Engineered nanoparticles are aquatic contaminants of emerging concern that exert ecotoxicological effects on a wide variety of organisms. We exposed cetyltrimethylammonium bromide-capped spherical gold nanoparticles to wood frog and bullfrog tadpoles with conspecifics and in combination with the other species continuously for 21 d, then measured uptake and localization of gold. Wood frog tadpoles alone and in combination with bullfrog tadpoles took up significantly more gold than bullfrogs. Bullfrog tadpoles in combination with wood frogs took up significantly more gold than controls. The rank order of weight-normalized gold uptake was wood frogs in combination > wood frogs alone > bullfrogs in combination > bullfrogs alone > controls. In all gold-exposed groups of tadpoles, gold was concentrated in the anterior region compared with the posterior region of the body. The concentration of gold nanoparticles in the anterior region of wood frogs both alone and in combination with bullfrogs was significantly higher than the corresponding posterior regions. We also measured depuration time of gold in wood frogs. After 21 d in a solution of gold nanoparticles, tadpoles lost >83% of internalized gold when placed in gold-free water for 5 d. After 10 d in gold-free water, tadpoles lost 94% of their gold. After 15 d, gold concentrations were below the level of detection. Our finding of differential uptake between closely related species living in similar habitats with overlapping geographical distributions argues against generalizing toxicological effects of nanoparticles for a large group of organisms based on measurements in only one species. Environ Toxicol Chem 2017;36:3351-3358. © 2017 SETAC.

show abstract

Growth Inhibition of Tadpoles Exposed to Sertraline in the Presence of Conspecifics

Cited by 12 publications

References 57 publications

Long‐term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations

Long‐term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations

Oxazepam Alters the Behavior of Crayfish at Diluted Concentrations, Venlafaxine Does Not

Differential uptake of gold nanoparticles by 2 species of tadpole, the wood frog (Lithobates sylvaticus) and the bullfrog (Lithobates catesbeianus)

Contact Info

Product

Resources

About