Higher Incidence of Cholelithiasis in Chronic Renal Failure Patients with Secondary Hyperparathyroidism Undergoing Peritoneal Dialysis

Barut, İbrahim; Tarhan, Ömer Rıdvan; Baykal, Bahattin; Demir, Murat; Celikbas, Bilal

doi:10.1080/08860220701260636

Cited by 9 publications

(11 citation statements)

References 32 publications

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“…Chronic liver disease is a well-recognized risk factor for cholelithiasis [4,23]. Fatty liver [12], hepatitis B [16,22], hepatitis C [6,29], elevated ALT levels [15], and cirrhosis [22,30,31] have all been found to be related to cholelithiasis in different small studies. In Taiwan there is known to be a higher prevalence of viral hepatitis than in other regions [32].…”

Section: Discussionmentioning

confidence: 99%

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Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study

et al. 2011

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BackgroundCholelithiasis has become a major health problem in Taiwan. The predominant type of gallstone found in Asian populations differs from that in the West, indicating possible differences in the etiology and risk factors for cholelithiasis. The aim of this study is to investigate the risk factors for cholelithiasis using data representative of the general population.MethodsWe performed a population-based, case-control study in which we analyzed medical data for 3725 patients newly diagnosed with cholelithiasis and 11175 gender- and age-matched controls with no history of cholelithiasis, using information obtained from the 2005 Registry for Beneficiaries of the National Health Insurance Research Database. Coexisting medical conditions were included in the analysis. Relative risks were estimated by adjusted odds ratio (OR) and 95% confidence interval (CI) using a multivariate logistic regression analysis.ResultsAfter controlling for the other covariates, multivariate logistic regression analysis identified the following as risk factors for cholelithiasis (in descending order of contribution): Among all patients - hepatitis C (OR = 2.78), cirrhosis (OR = 2.47), hepatitis B (OR = 2.00), obesity (OR = 1.89), and hyperlipidemia (OR = 1.54); Among women - hepatitis C (OR = 3.05), cirrhosis (OR = 1.92), obesity (OR = 1.91), menopause (OR = 1.61), hepatitis B (OR = 1.54), and hyperlipidemia (OR = 1.49). Diabetes mellitus appeared to have a marked influence on the development of cholelithiasis but was not identified as a significant independent risk factor for cholelithiasis.ConclusionsThe risk factors for cholelithiasis were obesity, hyperlipidemia, hepatitis B infection, hepatitis C infection, and cirrhosis in both genders, and menopause in females. Despite differences in the predominate type of gallstone in Asian versus Western populations, we identified no unique risk factors among the population of Taiwan.

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Section: Discussionmentioning

confidence: 99%

“…The relationship between chronic kidney disease and cholelithiasis continues to be investigated [30,45]. Chronic kidney disease may alter plasma concentrations of electrolytes, including calcium.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study

et al. 2011

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“…Thus, abnormal bile metabolism along with a low-protein diet has been suspected to cause the high prevalence of GBS among CKD5 patients. Secondary hyperparathyroidism was reported to be another potential candidate for the promotion of GBS formation in end-stage CKD patients [18]. Inflammation is also a possible risk factor for GBS formation.…”

Section: Discussionmentioning

confidence: 99%

The Risk of Gallbladder Stone Formation Is Increased in Patients with Predialysis Chronic Kidney Disease but Not Those Undergoing Chronic Hemodialysis Therapy

Kazama¹,

Kazama²,

Koda³

et al. 2009

Nephron Clin Pract

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Background: It is unclear whether the prevalence of gallbladder stones (GBS) is higher in patients with chronic kidney disease (CKD). Methods: A total of 398 patients with CKD of each of the 5 disease stages [CKD1: 26; CKD2: 52; CKD3: 58; CKD4: 48; CKD5: 214, of whom 61 were predialysis and 153 were on dialysis (CKD5D)] were included in this study. Those in whom GBS were detected by ultrasonographic examination or who had a history of cholecystectomy owing to GBS were considered GBS patients. Results: In comparison to the GBS prevalence of 5.9% in the control group, that in CKD patients increased with the advancement of the disease stage (CKD1: 7.7%; CKD2: 15.4%; CKD3: 19.0%; CKD4: 20.8%; CKD5 predialysis: 21.3%; CKD5D: 22.9%). The prevalence was significantly greater in CKD5 patients than in the control group. CKD5 is a risk factor for GBS independent of age or sex. However, no significant relationship was found between the prevalence of GBS and the duration of hemodialysis therapy in CKD5D patients. Age was the only factor that was associated with GBS in predialysis CKD patients. Conclusion: The risk of GBS formation was high in predialysis CKD patients. Although the risk disappeared in CKD5D patients, the prevalence of GBS was still significantly higher than in the control population. Factors that promote GBS formation in predialysis CKD patients and/or that inhibit GBS formation in CKD5D patients remain unknown.

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“…Barut et al reported that secondary hyperparathyroidism might influence the development of cholelithiasis in chronic renal failure-peritoneal dialysis patients [1]. These results suggest that secondary hyperparathyroidism caused by hypercalciuria in furosemide use or Bartter syndrome could be one of the important factors in the development of cholelithiasis.…”

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confidence: 92%

Comment on: Bartter syndrome and cholelithiasis in an infant: is this a mere coincidence? (Eur J Pediatr 2008;167(1):109–110)

Shin

Lee

2008

Eur J Pediatr

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Higher Incidence of Cholelithiasis in Chronic Renal Failure Patients with Secondary Hyperparathyroidism Undergoing Peritoneal Dialysis

Abstract: We found that the incidence of CL in CRF-PD patients with secondary hyperparathyroidism was higher than CRF-PD patients with normal PTH levels. It was also detected that female gender, high creatinine levels, and elevated PTH levels might influence the development of CL in CRF-PD patients.

Cited by 9 publications

References 32 publications

Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study

Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study

The Risk of Gallbladder Stone Formation Is Increased in Patients with Predialysis Chronic Kidney Disease but Not Those Undergoing Chronic Hemodialysis Therapy

Comment on: Bartter syndrome and cholelithiasis in an infant: is this a mere coincidence? (Eur J Pediatr 2008;167(1):109–110)

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