Higher extracellular water to total body water ratio was associated with chronic kidney disease progression in type 2 diabetes

Low, Sui Pheng; Pek, Sharon Li Ting; Liu, Yan Lun; Moh, Angela; Ang, Keven; Tang, Wern Ee; Lim, Ziliang; Tavintharan, Subramaniam; Sum, Chee Fang; Lim, Chin Leong; Ali, Yusuf; Lim, Su Chi

doi:10.1016/j.jdiacomp.2021.107930

Cited by 15 publications

(17 citation statements)

References 30 publications

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“…The inclusion criteria were the ability to perform daily living activities independently and follow instructions. The exclusion criteria were an ECW/TBW ratio greater than 0.4 [16,17] and the use of a pacemaker. This study was approved by the Ethics Committee of Tokyo Medical and Dental University (ref: D2014-047).…”

Section: Participantsmentioning

confidence: 99%

Higher extracellular water/total body water ratio is associated with lower tongue and grip strength: A cross-sectional study

et al. 2023

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Purpose: This study aimed to investigate the relationship between tongue factors (tongue strength and tongue volume), systemic factors (grip strength and walking speed), and the extracellular water/total body water ratio. Methods: This cross-sectional study included community-dwelling adults. Body water composition and skeletal muscle mass index were measured using bioelectrical impedance analysis. Moreover, tongue grip strength, tongue volume, occlusal support condition (Eichner classification), and walking speed were measured. Multiple linear regression analysis was performed to investigate the relationship between the tongue and systemic factors as dependent variables and body water composition. Results: We included 171 community-dwelling adults (62 men and 109 women) aged 70.0 years (interquartile range: 8). Tongue strength (r=-0.22, p=0.004) and grip strength (r=-0.39, p<0.001) were correlated with the extracellular water/total body water ratio. In multiple linear regression analysis, tongue strength was associated with the extracellular water/total body water ratio (β=-0.20, p=0.034), and grip strength was associated with the extracellular water/total body water ratio (β=-0.12, p=0.047), sex, body mass index, skeletal muscle mass index, and occlusal support condition. Conclusions: A higher extracellular water/total body water ratio indicates lower tongue and grip strength. Dentists and dental hygienists should be aware of systemic factors present in patients with lower tongue and grip strength. These findings may lead to further medical investigations and diagnosis of other systemic diseases.

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Section: Participantsmentioning

confidence: 99%

Higher extracellular water/total body water ratio is associated with lower tongue and grip strength: A cross-sectional study

et al. 2023

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“…Lower PhA values are associated with a lower body cell mass and imbalances in cellular water (i.e., expansion of absolute ECW or increased ECW/ICW). This occurs in disease states [ 3 , 69 ], and might be explained by the more oxidative environment of the extracellular fluid, versus that of the intracellular space [ 70 ]. During inflammation, Xc decreases in response to the lower capacitance of damaged cell membranes, and this occurs simultaneously with a reduction in R because of increases in ECW (measured at 50 kHz).…”

Section: Phase Angle Inflammation and Cellular Damagementioning

confidence: 99%

Phase angle and cellular health: inflammation and oxidative damage

Silva

Orsso

Gonzalez

et al. 2022

Rev Endocr Metab Disord

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Phase angle is a composite measure that combines two raw bioelectrical impedance analysis measures: resistance and reactance. Phase angle has been considered an indicator of cellular health, integrity, and hydration. As inflammation and oxidative stress can damage cellular structures, phase angle has potential utility in early detecting inflammatory and oxidative status. Herein, we aimed to critically review the current understanding on the determinants of phase angle and its relationship with markers of inflammation and oxidative stress. We also discussed the potential role of phase angle in detecting chronic inflammation and related adverse outcomes. Several factors have been identified as predictors of phase angle, including age, sex, extracellular to intracellular water ratio, and fat-free mass. In addition to these factors, body mass index (BMI) also seems to influence phase angle. Available data also show that lower phase angle values are correlated (negligible to high correlation coefficients) with higher c-reactive protein, tumour necrosis factor-α, interleukin-6, and interleukin-10 in studies involving the general and aging populations, as well as patients with chronic conditions. Although fewer studies have evaluated the relationship between phase angle and markers of oxidative stress, available data also suggest that phase angle has potential to be used as an indicator (for screening) of oxidative damage. Future studies including diverse populations and bioelectrical impedance devices are required to confirm the validity and accuracy of phase angle as a marker of inflammation and oxidative stress for clinical use.

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“…As ECW/TBW increased, cold score increased, and as ECW/TBW decreased, the heat score increased. Previous studies reported that ECW/TBW increased with age and in people with sarcopenia, obesity, edema, acute heart failure, kidney disease, and hepatic diseases, and reflects the inflammation and nutritional status of patients [28][29][30] . ECW/TBW, which showed the smallest correlation coefficients, was included in the final model possibly because it provided additional information that the included anthropometric variables could not.…”

Section: Discussionmentioning

confidence: 99%

Study on the Anthropometric and Body Composition Indices for Prediction of Cold and Heat Patter

2021

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Objectives: Many symptoms of cold and heat patterns are related to the thermoregulation of the body. Thus, we aimed to study the association of cold and heat patterns with anthropometry/body composition.Methods: The cold and heat patterns of 2000 individuals aged 30–55 years were evaluated using a self-administered questionnaire.Results: Among the anthropometric and body composition variables, body mass index (-0.37, 0.39) and fat mass index (-0.35, 0.38) had the highest correlation coefficients with the cold and heat pattern scores after adjustment for age and sex in the cold-heat group, while the correlation coefficients were relatively lower in the non-cold-heat group. In the cold-heat group, the most parsimonious model for the cold pattern with the variables selected by the best subset method and Lasso included sex, body mass index, waist-hip ratio, and extracellular water/total body water (adjusted R2 = 0.324), and the model for heat pattern additionally included age (adjusted R2 = 0.292).Conclusions: The variables related to obesity and water balance were the most useful for predicting cold and heat patterns. Further studies are required to improve the performance of prediction models.

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Higher extracellular water to total body water ratio was associated with chronic kidney disease progression in type 2 diabetes

Cited by 15 publications

References 30 publications

Higher extracellular water/total body water ratio is associated with lower tongue and grip strength: A cross-sectional study

Higher extracellular water/total body water ratio is associated with lower tongue and grip strength: A cross-sectional study

Phase angle and cellular health: inflammation and oxidative damage

Study on the Anthropometric and Body Composition Indices for Prediction of Cold and Heat Patter

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