Higher education affects accelerated cortical thinning in Alzheimer's disease: a 5-year preliminary longitudinal study

Cho, Hanna; Jeon, Sohee; Kim, Chang-Soo; Ye, Byoung Seok; Kim, Geon Ha; Noh, Young; Kim, Hee Jin; Yoon, Cindy W.; Kim, Yeo Jin; Kim, Jung Hyun; Park, Sang Eon; Kim, Sung Tae; Lee, Jong Min; Kang, Sohi; Suh, Mee Kyung; Chin, Juhee; Na, Duk L.; Kang, Dae Ryong; Seo, Sang Won

doi:10.1017/s1041610214001483

Cited by 18 publications

(12 citation statements)

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“…Previous studies by our group [ 10 , 21 , 22 ] suggested there were differences in the relationships between levels of education and cortical thickness among levels of cognition. That is, healthy control subjects showed a positive correlation between level of education and cortical thickness, whereas patients with dementia showed a negative correlation between level of education and cortical thickness.…”

Section: Introductionmentioning

confidence: 90%

The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis

et al. 2018

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BackgroundThe protective effect of education has been well established in Alzheimer’s disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear. We examined the correlation of education with cortical thickness and cerebral small vessel disease markers in patients with pure subcortical vascular mild cognitive impairment (svMCI) and patients with pure subcortical vascular dementia (SVaD).MethodsWe analyzed 45 patients with svMCI and 47 patients with SVaD with negative results on Pittsburgh compound B positron emission tomographic imaging who underwent structural brain magnetic resonance imaging. The main outcome was cortical thickness measured using surface-based morphometric analysis. We also assessed the volumes of white matter hyperintensities (WMH) and numbers of lacunes as other outcomes. To investigate the correlation of education with cortical thickness, WMH volume, and number of lacunes, multiple linear regression analyses were performed after controlling for covariates, including Mini Mental State Examination, in the svMCI and SVaD groups.ResultsIn the SVaD group, higher education was correlated with more severe cortical thinning in the bilateral dorsolateral frontal, left medial frontal, and parahippocampal areas, whereas there was no correlation of education with cortical thickness in the svMCI group. There was no correlation between education and cerebral small vessel disease, including WMH and lacunes, in both patients with svMCI and patients with SVaD.ConclusionsOur findings suggest that the compensatory effects of education on cortical thinning apply to patients with SVaD, which might be explained by the cognitive reserve hypothesis.

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Section: Introductionmentioning

confidence: 90%

The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis

et al. 2018

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“…Very few studies have examined the direct effect of an education intervention on cortical thickness [10] and such studies usually possess only small sample sizes, but education level has been demonstrated to be related to better brain maintenance, i.e. reduced age-related atrophy, and cognitive reserve, but the studies have not been unequivocal [11,12] Both intelligence and educations thickness relations are dwarfed by associations with age and ageing, e.g. [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Cortical thickness and its associations with age, total cognition and education across the adult lifespan

et al. 2020

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Early-life education (years of schooling) has been investigated in regards to cognition, health outcomes and mortality. It has been shown to confer cognitive reserve that might lessen the impact of brain pathology and its impact on cognitive and motor functioning in a variety of neurodegenerative diseases and, for instance, to influence electrical activity [Begum, T., Reza, F., Ahmed, I., & Abdullah, J. M. (2014). Influence of education level on design-induced N170 and P300 components of event related potentials in the human brain.

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“…Although it is not exactly known to what extent a higher level of education affects AD, it has been indicated that a higher level of education may have an important function, because people with higher education more easily develop strategies to compensate for the possible adverse effects of cognitive impairment in the early stages of AD, and hence the effects of symptoms on daily life present late (21). The risk of developing AD decreases at a rate of 17% for each extra year of education, while having a lower economic level and a lower status occupation poses an increased risk of AD development (22).…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Anesthesia in Geriatric Patients During Endoscopic Retrograde Cholangiopancreatography Abstract

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2018

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Introduction:Although it has been proven that theory of mind functions is deteriorated in amnestic type mild cognitive impairment, the relationship between this deterioration and cognitive functions has not been researched. The aim of this study is to compare amnestic type mild cognitive impairment patients with healthy individuals in terms of theory of mind functions and to determine the relationship between theory of mind functions and the functions of language and memory in amnestic type mild cognitive impairment patients.Materials and Method: Thirty-eight patients with amnestic type mild cognitive impairment were compared with 34 healthy individuals in this study. The Reading the Mind in the Eyes Test, Hinting Test, Boston Naming Test, Wechsler Adult Intelligence Scale-Revised Vocabulary Test Score, Öktem Verbal Memory Process Test, and Clock Drawing Test were used for evaluation.Results: The scores of the amnestic type mild cognitive impairment group in the tests evaluating theory of mind functions and the functions of language, memory and Clock Drawing Test were lower than those of the control group. The scores of the amnestic type mild cognitive impairment group in the tests evaluating the theory of mind functions were not associate with the tests evaluating the functions of language and memory.Conclusion: Amnestic type mild cognitive impairment patients perform worse in terms of affective and cognitive theory of mind functions compared with healthy aging individuals. The impairment of theory of mind functions in amnestic type mild cognitive impairment patients is thought to be independent of the deterioration of language and memory functions.

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Higher education affects accelerated cortical thinning in Alzheimer's disease: a 5-year preliminary longitudinal study

Abstract: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.

Cited by 18 publications

References 33 publications

The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis

The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis

Cortical thickness and its associations with age, total cognition and education across the adult lifespan

Retrospective Analysis of Anesthesia in Geriatric Patients During Endoscopic Retrograde Cholangiopancreatography Abstract

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