Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study

Abstract

BackgroundSeveral epidemiological studies have determined the associations between coffee intake level and skin cancer risk; however, the results were not yet conclusive. Herein, we conducted a systematic review and meta-analysis of the cohort and case-control studies for the association between coffee intake level and malignant melanoma (MM) risk.MethodsStudies were identified through searching the PubMed and MEDLINE databases (to November, 2015). Study-specific risk estimates were pooled under the random-effects model.ResultsTwo case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases) were identified. For caffeinated coffee, the pooled relative risk (RR) of MM was 0.81 [95% confidential interval (95% CI) = 0.68–0.97; P-value for Q-test = 0.003; I2 = 63.5%] for those with highest versus lowest quantity of intake. In the dose-response analysis, the RR of MM was 0.955 (95% CI = 0.912–0.999) for per 1 cup/day increment of caffeinated coffee consumption and linearity dose-response association was found (P-value for nonlinearity = 0.326). Strikingly, no significant association was found between the decaffeinated coffee intake level and MM risk (pooled RR = 0.92, 95% CI = 0.81–1.05; P-value for Q-test = 0.967; I2 = 0%; highest versus lowest quantity of intake).ConclusionsThis meta-analysis suggested that caffeinated coffee might have chemo-preventive effects against MM but not decaffeinated coffee. However, larger prospective studies and the intervention studies are warranted to confirm these findings.

A prospective study of tea and coffee intake and risk of glioma

“…Increased consumption of tea and coffee, two of the most popular beverages worldwide, has been associated with decreased risk of cancers of several sites in human studies. [1][2][3][4][5][6][7][8][9][10] Less is known about the association between tea or coffee consumption and risk of glioma, a cancer for which few lifestyle factors have been identified. 11,12 Coffee is a rich source of caffeine, and both tea and coffee contain additional biologically active compounds.…”

Coffee and Skin: What do We Know About it?

“…[11][12][13] POTENTIAL ANTI-CARCINOGENIC EFFECTS OF CAFFEINE There is a growing literature indicating that caffeine may protect against melanoma and non-melanoma skin cancers. [14][15][16][17][18][19][20][21][22][23][24][25][26] In coffee, although there are other potential anticancer ingredients other than caffeine, caffeine is one of the mostly researched compounds in chemopreventive power of coffee. Caffeine exerts its antiproliferative and anti-carcinogenic action via regulating cell growth, development and apoptosis.…”

“…Caffeine modulates cell cycle and increases UV-induced apoptosis through p53dependent and p53-independent biological pathways. Data from recent studies have revealed an inhibitory effect of caffeine on the proliferation of both melanoma and nonmelanoma cell lines [14][15][16][17][18][19][20][21][22][23][24][25][26].…”

An insight towards anticancer potential of major coffee constituents

“…Several scientific studies on animal models and humans highlight the cancer preventive potential of phytochemicals [6][7][8][9][10]. Coffee is the most widely consumed beverages in the world and has been reported to have significant anticarcinogenic effects [11][12][13].…”