Higher Branched-Chain Amino Acid Intake Is Associated with Handgrip Strength among Korean Older Adults

Park, Seonghee; Chae, Minjeong; Park, Hyoungsu; Park, Kyong

doi:10.3390/nu13051522

Cited by 16 publications

(12 citation statements)

References 47 publications

(52 reference statements)

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“…Chae et al [ 30 ] observed a positive and significant correlation between leucine intake and muscle mass index in healthy middle-aged non-obese individuals (50–64 years). Similar results were observed in an older cohort (>65 years), with a significant correlation between leucine intake and handgrip strength [ 31 ]. Besides corroborating with previous reports, our results expand the literature by showing the importance of leucine intake for muscle mass in individuals above 65 years.…”

Section: Discussionsupporting

confidence: 86%

“…Based on appealing acute findings of leucine supplementation, observational data analyses have investigated the protective effects of habitual leucine intake on morphological and functional outcomes during aging [ 30 , 31 ]. Chae et al [ 30 ] observed a positive and significant correlation between leucine intake and muscle mass index in healthy middle-aged non-obese individuals (50–64 years).…”

Section: Discussionmentioning

confidence: 99%

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Daily Leucine Intake Is Positively Associated with Lower Limb Skeletal Muscle Mass and Strength in the Elderly

et al. 2021

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Higher daily protein intake, with an emphasis on leucine content, is thought to mitigate age-related anabolic resistance, potentially counteracting age-related morphological and functional declines. The present study investigated potential associations between total daily leucine intake and dependent variables, including quadriceps muscle cross-sectional area (CSA) and maximum dynamic muscle strength (1-RM) in a cohort of healthy free-living older individuals of both sexes (n = 67; 34/33 men/women). Participants performed three 24 h dietary recalls and underwent a magnetic resonance imaging exam followed by 1-RM tests. Our results demonstrate moderate associations between total daily leucine and both quadriceps CSA (r = 0.42; p = 0.004) and 1-RM (r = 0.45; p = 0.001). Furthermore, our exploratory biphasic linear regression analyses, adjusted for sex, age, and protein intake relative to body weight, revealed a plateau for daily leucine intake and muscle mass and muscle strength (~7.6–8.0 g·day−1) in older adults. In conclusion, we demonstrated that total daily leucine intake is associated with muscle mass and strength in healthy older individuals and this association remains after controlling for multiple factors, including overall protein intake. Furthermore, our breakpoint analysis revealed non-linearities and a potential threshold for habitual leucine intake, which may help guide future research on the effects of chronic leucine intake in age-related muscle loss.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Daily Leucine Intake Is Positively Associated with Lower Limb Skeletal Muscle Mass and Strength in the Elderly

et al. 2021

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“…Additionally, it has been reported that the masticatory discomfort attributable to tooth loss affects the nutritional status, owing to improper dietary habits [12]. In addition, previous studies have reported that the consumption of branched-chain amino acids is associated with handgrip strength [32]. Hence, the direct or indirect effect of tooth loss on physical strength can explain this association with handgrip strength to a certain extent.…”

Section: Discussionmentioning

confidence: 99%

Association between Oral Health Status and Relative Handgrip Strength in 11,337 Korean

Kim

Choi

et al. 2021

JCM

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Grip strength is a simple indicator of physical strength and is closely associated with systemic health. Conversely, oral health has also been reported to have an important association with systemic health. The present study aimed to assess the effect of oral health status on relative handgrip strength. The data pertaining to 11,337 participants were obtained by means of the seventh Korea National Health and Nutrition Survey (2016 to 2018). Oral health status was evaluated on the basis of the presence of periodontitis and number of remaining teeth (PT, present teeth). Relative handgrip strength was evaluated by means of a digital dynamometer and the value pertaining to the lower 25% of measurements was used as the quartile by gender. The association between oral health status and relative handgrip strength was evaluated by means of multiple regression analysis and multiple logistic regression analysis with covariate correction. Analysis of the crude model revealed a significant association in the group of patients with periodontal disease (odds ratio = 1.69, 95% confidence interval: 1.51–1.89). However, analysis with adjusted covariates revealed that the association was not statistically significant. Moreover, statistical analysis after adjustment for covariates revealed a consistent correlation between PT and relative handgrip strength as categorical and continuous variables. Hence, the present study observed a significant association between oral health status and relative handgrip strength among the Korean adult population.

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“…Especially the EAAs, which are not synthesized in the body, are known to stimulate muscle synthesis [ 7 , 8 , 26 , 27 , 28 ] by activating the mammalian/mechanistic target of rapamycin complex 1 pathway [ 29 ]. Many studies have attempted to investigate the association between specific EAAs and muscle strength [ 30 , 31 , 32 ]. However, supplementing only a specific amino acid may induce absorption competition between amino acids that results in an imbalance of amino acids [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Essential Amino Acid Intake Is Associated with High Muscle Strength in Korean Older Adults

Park²,

Park

2022

Nutrients

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The relationship between daily dietary intake of an individual or all essential amino acids (EAAs) and muscle strength in older adults is still inadequately characterized. This population-based cross-sectional study included 5971 participants aged ≥65 years from the 2014–2019 Korea National Health and Nutrition Examination Survey. Dietary information was derived from the 24 h recall data. Total essential amino acid score (EAAS) was calculated with an intake that satisfied the recommended nutrient intake (RNI) in each essential amino acid (EAA). The mean handgrip strength was estimated from triplicate measurements obtained using the dominant hand, and high muscle strength was defined as handgrip strength ≥28 kg for men and ≥18 kg for women. Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression models. After multivariable adjustment, we found that a high total EAAS was associated with high muscle strength in Korean older adults (OR: 1.38, 95% CI: 1.07–1.79). High muscle strength was significantly enhanced with increased total EAA intake from animal sources (OR: 1.27, 95% CI: 1.02–1.58), but there was no significant association with total EAA intake from non-animal sources. EAA intake and high muscle strength are associated based on a positive dose-response relationship in which high muscle strength is further increased when the overall EAA intake meets the RNI. Thus, Korean older adults should ensure an adequate intake of all EAAs from various food sources (especially animal sources) to meet the RNI as a prerequisite for achieving high muscle strength.

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Higher Branched-Chain Amino Acid Intake Is Associated with Handgrip Strength among Korean Older Adults

Cited by 16 publications

References 47 publications

Daily Leucine Intake Is Positively Associated with Lower Limb Skeletal Muscle Mass and Strength in the Elderly

Daily Leucine Intake Is Positively Associated with Lower Limb Skeletal Muscle Mass and Strength in the Elderly

Association between Oral Health Status and Relative Handgrip Strength in 11,337 Korean

Dietary Essential Amino Acid Intake Is Associated with High Muscle Strength in Korean Older Adults

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