Higher body mass index and larger waist circumference may be predictors of thyroid carcinoma in patients with Hürthle‐cell lesion/neoplasm fine‐needle aspiration diagnosis

Arduç, Ayşe; Doğan, Berçem Ayçıçek; Tuna, Mazhar Müslüm; Tütüncü, Yasemin; Işık, Serhat; Berker, Dilek; Güler, Serdar

doi:10.1111/cen.12628

Cited by 22 publications

(17 citation statements)

References 35 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, previous studies have proposed several cytological findings to be predictive of malignancy, such as nuclear pleomorphism, large- or small-cell dysplasia, nuclear enlargement, hyperchromatism, cellular crowding, prominent nucleoli, or background features (Table 4) [4, 9, 19]. Several clinical features have also been variably related to HC carcinoma (male gender, the size of the nodule, tumor fixation, body mass index, a larger waist circumference, thyroid function tests, and serum triglyceride level) (Table 5) [19-22]. Cellular polymorphism, cystic changes, the presence of inflammatory cells, a macrofollicular or honeycomb cell arrangement, the absence of nucleoli, and abundant colloid have been associated with benignity [5].…”

Section: Discussionmentioning

confidence: 99%

Preoperative Diagnosis of Neoplastic or Malignant Hürthle Cell Lesions: A Chimera?

Arco¹,

Fernández-Aceñero²

2018

Acta Cytologica

View full text Add to dashboard Cite

Objective: We aimed to review all cytological specimens with Hürthle cells (HC) diagnosed in our institution, identify cytological features related to neoplastic (adenoma or carcinoma) and malignant histology, and discuss the role of clinicopathological findings and clinical management in these cases. Study Design: We included 359 thyroid fine-needle aspiration cytology cases in our study. We reviewed the clinical and cytological features of surgical cases and correlated them with histological diagnosis. We also reviewed the literature on this issue. Results: We found a significant association between neoplasia and highly cellular smears, the absence of colloid, the presence of microfollicles, large-cell dysplasia, prominent nucleoli or macronucleoli, coarse chromatin, nuclear grooves and inclusions, nuclear irregularity, and pleomorphism. The absence of colloid, high cellularity, > 25% of isolated HC, the presence of tridimensional groups, transgressing vessels, nuclear irregularity, prominent nucleoli or macronucleoli, coarse chromatin, hyperchromatism, pleomorphism, and diffuse large-cell dysplasia were features significantly associated with malignancy. Conclusions: No cytological feature alone can predict histological outcome, but all findings related to a neoplastic or malignant histology must be assessed. Individualized management protocols should be developed in each institution.

show abstract

Section: Discussionmentioning

confidence: 99%

Preoperative Diagnosis of Neoplastic or Malignant Hürthle Cell Lesions: A Chimera?

Arco¹,

Fernández-Aceñero²

2018

Acta Cytologica

View full text Add to dashboard Cite

show abstract

“…1 Increased BMI is a major risk factor for morbidity, such as cardiovascular disease, diabetes, musculoskeletal disorders, and some cancer types such as endometrial, breast, ovarian, prostate, liver, kidney, and colon cancers. 2 Obese patients have a higher risk of thyroid cancer, 3,4 possibly due to alterations in the level of adipokines and sex hormones. 4 Furthermore, in case of macro-cancers, obese patients are at higher risk for locoregional recurrence or persistence.…”

mentioning

confidence: 99%

Impact of body mass index on post‐thyroidectomy morbidity

et al. 2019

View full text Add to dashboard Cite

Background The impact of obesity on total thyroidectomy (TT) morbidity (recurrent laryngeal nerve palsy and hypocalcaemia) remains largely unknown. Methods In a prospective study (NCT01551914), patients were divided into five groups according to their body mass index (BMI): underweight, normal weight, overweight, obese, and severely obese. Preoperative and postoperative serum calcium was measured. Recurrent laryngeal nerve (RLN) function was evaluated before discharge, and if abnormal, at 6 months. Results In total 1310 patients were included. Baseline characteristics were similar across BMI groups except for age and sex. Postoperative hypocalcaemia was more frequent in underweight compared to obese patients but the difference was not statistically significant in multivariate analysis. There was no difference between groups in terms of definitive hypocalcaemia, transient and definitive RLN palsy, and postoperative pain. Conclusion Obesity does not increase intraoperative and postoperative morbidity of TT, despite a longer duration of the procedure.

show abstract

“…Glucocorticoid treatment as well as Cushing syndrome are regarded as two very important factors of reduced bone mass and increased fracture risk 6,7 . Other studies have shown this association for subclinical hypercortisolism as well [8][9][10][11][12][13][14][15][16] . Although endogenous cortisol secretion follows a circadian rhythm and the absence of this rhythm figures the hypercortisolism, literature is quite poor about the association between cortisol rhythm and osteoporosis or osteopenia.…”

Section: Introductionmentioning

confidence: 83%

Circadian clock mechanisms in adrenal adenomas are not related to osteopenia and osteoporosis

Κatsoulis¹,

Ioannidis²,

Karageorgos³

et al. 2017

JRPMS

View full text Add to dashboard Cite

Higher body mass index and larger waist circumference may be predictors of thyroid carcinoma in patients with Hürthle‐cell lesion/neoplasm fine‐needle aspiration diagnosis

Abstract: A great BMI and large WC were associated with higher thyroid cancer risk in patients with FNAB diagnosis of HLN. Further studies are needed to use BMI or WC in the management of patients with HLN.

Cited by 22 publications

References 35 publications

Preoperative Diagnosis of Neoplastic or Malignant Hürthle Cell Lesions: A Chimera?

Preoperative Diagnosis of Neoplastic or Malignant Hürthle Cell Lesions: A Chimera?

Impact of body mass index on post‐thyroidectomy morbidity

Circadian clock mechanisms in adrenal adenomas are not related to osteopenia and osteoporosis

Contact Info

Product

Resources

About