Higher Blood Lead Level Is Associated With Increased Likelihood of Abdominal Aortic Calcification

Zheng, Qin; Li, Hancong; Xu, Yingfei; Li, Jiameng; Su, Baihai; Liao, Ri-Qiang

doi:10.3389/fcvm.2021.747498

Cited by 10 publications

(4 citation statements)

References 41 publications

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“…Nevertheless, numerous theories and routes have been suggested in light of previous studies. Research has established a correlation between lead exposure and an elevation in bodily in ammation and oxidative stress [20,21]. Chronic in ammation can affect the bladder and urinary tract tissues, potentially leading to urinary symptoms, including nocturia [22].…”

Section: Discussionmentioning

confidence: 99%

The relationships between blood lead level and nocturia prevalence in US adults

Wang,

Zhang,

Wang

et al. 2024

Preprint

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Purpose The purpose of this study was to examine the association between blood lead level and the prevalence of nocturia in a representative sample of American civilians living outside of institutions. Methods We analyzed data from eight National Health and Nutrition Examination Survey (NHANES) survey cycles spanning from 2005 to 2020, focusing on individuals aged 20 years or older (n = 11,919). Blood lead level was categorized into two groups (< 2 µg/dL and ≥ 2 µg/dL), and the presence of nocturia was assessed based on questionnaire responses. We used multivariable logistic regression models to explore the association between blood lead level and nocturia while adjusting for various covariates, including sex, ratio of family income to poverty (RIP), lipid profile, age, body mass index (BMI), race, citizenship, sleep trouble, diabetes, and hypertension. In order to acknowledge the variation in baseline data regarding the prevalence of nocturia, subgroup analyses were performed. Results Among the study participants, 31.70% reported experiencing nocturia. Nocturia showed significant variations among different demographic and health-related factors. Individuals with higher blood lead level (≥ 2 µg/dL) exhibited a higher likelihood of experiencing nocturia compared to those with lower level (< 2 µg/dL) in all three models (Model 1: OR 1.46, 95%CI 1.29–1.66, P < 0.0001; Model 2: OR 1.23, 95%CI 1.07–1.42, P = 0.01; Model 3: OR 1.23, 95%CI 1.07–1.42, P = 0.01). Subgroup analyses revealed significant associations in various subgroups, including age, sex, sleep trouble, diabetes, diabetes, hypertension, and race. Conclusions This study, for the first time, reported the correlation between blood lead level and nocturia. We found that when blood lead levels were ≥ 2 µg/dL, there was a 23% increased risk of nocturia occurrence.

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Section: Discussionmentioning

confidence: 99%

The relationships between blood lead level and nocturia prevalence in US adults

Wang,

Zhang,

Wang

et al. 2024

Preprint

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“…AAC‐24 scoring used semiquantitative techniques to evaluate AAC 25 . Based on AAC scores, we categorized calcification into three groups: no calcification (AAC = 0), mild to moderate calcification (0＜AAC ≤ 6), and severe calcification (AAC ＞ 6) 26 …”

Section: Participants and Methodsmentioning

confidence: 99%

Association between dietary total choline and abdominal aorta calcification among older US adults: A cross‐sectional study of the National Health and Nutrition Examination Survey

Zhang,

Han,

et al. 2023

J Parenter Enteral Nutr

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BackgroundNumerous studies indicate a potential bidirectional association between dietary choline intake and its derivative, betaine, and subclinical atherosclerosis. However, little research has been conducted on the relationship between dietary choline and severe abdominal aortic calcification (SAAC).MethodsThis cross‐sectional study analyzed population‐based data from the National Health and Nutrition Examination Survey (2013–2014). Choline intake and food sources were measured using two 24‐h dietary‐recall interviews. The abdominal aortic calcification score was measured using a dual‐emission x‐ray absorptiometry scan. To assess the relationship between choline intake and SAAC, the study utilized restricted cubic spline and a multivariable logistic regression model.ResultsAmong the 2640 individuals included in the study, 10.9% had SAAC. After adjusting for all selected covariates, compared with the lowest quartile of dietary choline, the odds ratios of SAAC for the second‐quartile, third‐quartile, and fourth‐quartile dietary choline intake were 0.63 (95% confidence interval [CI], 0.43–0.93), 0.63 (95% CI, 0.42–0.94), and 0.77 (95% CI, 0.5–1.16), respectively. The study found an L‐shaped relationship between dietary choline and SAAC in the dose‐response analysis. Subgroup analyses did not demonstrate any statistically significant interaction effects for any subgroup.ConclusionThe study found that a higher intake of dietary choline is associated with a lower prevalence of SAAC. The dose‐response analysis revealed an L‐shaped relationship between dietary choline and SAAC. However, further studies are warranted to investigate the direct role of choline in the development of SAAC.

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“…The total AAC score ranged from 0 to 24, and a higher AAC score indicated a more serious calcification condition. AAC score > 6 was used as a commonly reported cut-off point for SAAC 21,[58][59][60] . Both AAC score and SAAC were included as outcome variables in our analysis.…”

Section: Assessment Of Abdominal Aortic Calcification Scores the Calc...mentioning

confidence: 99%

The association between weight-adjusted-waist index and abdominal aortic calcification in adults aged ≥ 40 years: results from NHANES 2013–2014

Zheng

et al. 2022

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The negative effects of obesity on the cardiovascular health have drawn much attention. Weight-adjusted-waist index (WWI) has been proved to reflect weight-independent centripetal obesity. However, the association between WWI and abdominal aortic calcification (AAC) has not been reported before. Using data from National Health and Nutrition Examination Survey 2013–2014, we aimed to determine the relationship of WWI and AAC in adults aged ≥ 40 years. WWI was determined by dividing waist circumference by the square root of weight. AAC was measured by dual-energy X-ray absorptiometry and quantified by Kauppila scores. Severe AAC (SAAC) was defined as an AAC score > 6. We utilized weighed multivariable logistic regression and generalized additive model to explore the independent association between WWI and AAC. Threshold effects were further calculated by two-piecewise linear regression model. 3082 participants were enrolled in our analysis, of which 48.2% were male. WWI was positively associated with AAC scores (β = 0.34, 95% CI 0.05–0.63) and exhibited a nonlinear relationship with SAAC. On the left of the breakpoint (WWI = 11.11), WWI and SAAC were positively associated (OR = 2.86, 95% CI 1.40–5.84), while no such relationship was found on the right (OR = 1.07, 95% CI 0.77–1.48). Our findings indicated that WWI may serve as a simple biomarker of AAC in US adults aged ≥ 40 years.

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Higher Blood Lead Level Is Associated With Increased Likelihood of Abdominal Aortic Calcification

Cited by 10 publications

References 41 publications

The relationships between blood lead level and nocturia prevalence in US adults

The relationships between blood lead level and nocturia prevalence in US adults

Association between dietary total choline and abdominal aorta calcification among older US adults: A cross‐sectional study of the National Health and Nutrition Examination Survey

The association between weight-adjusted-waist index and abdominal aortic calcification in adults aged ≥ 40 years: results from NHANES 2013–2014

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