High-yield preparation of graphene oxide from small graphite flakes via an improved Hummers method with a simple purification process

Ji, Chen; Li, Yingru; Huang, Liang; Li, Chun; Shi, Gaoquan

doi:10.1016/j.carbon.2014.10.033

Cited by 471 publications

(232 citation statements)

References 31 publications

(54 reference statements)

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“…24,25 GO hydrogel was prepared based on our previous work except that no fish sperm DNA was added. 23 A total of 0.5 mL of 4.05 mg/mL GO was dropped into a 2 mL conicalbottom centrifuge tube, which was heated at 95°C for 1 h in a thermomixer and cooled down to room temperature to form GO hydrogel.…”

Section: Methodsmentioning

confidence: 99%

A hydrogel biosensor for high selective and sensitive detection of amyloid-beta oligomers

Sun

Zhong

Gui

et al. 2018

IJN

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Background Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive and memory impairment. It is the most common neurological disease that causes dementia. Soluble amyloid-beta oligomers (AβO) in blood or cerebrospinal fluid (CSF) are the pathogenic biomarker correlated with AD. Methods A simple electrochemical biosensor using graphene oxide/gold nanoparticles (GNPs) hydrogel electrode was developed in this study. Thiolated cellular prion protein (PrP C ) peptide probe was immobilized on GNPs of the hydrogel electrode to construct an AβO biosensor. Electrochemical impedance spectroscopy was utilized for AβO analysis. Results The specific binding between AβO and PrP C probes on the hydrogel electrode resulted in an increase in the electron-transfer resistance. The biosensor showed high specificity and sensitivity for AβO detection. It could selectively differentiate AβO from amyloid-beta (Aβ) monomers or fibrils. Meanwhile, it was highly sensitive to detect as low as 0.1 pM AβO in artificial CSF or blood plasma. The linear range for AβO detection is from 0.1 pM to 10 nM. Conclusion This biosensor could be used as a cost-effective tool for early diagnosis of AD due to its high electrochemical performance and bionic structure.

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Section: Methodsmentioning

confidence: 99%

A hydrogel biosensor for high selective and sensitive detection of amyloid-beta oligomers

Sun

Zhong

Gui

et al. 2018

IJN

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“…Recently, there has been growing interest in exfoliation of layered materials to produce two-dimensional (2D) nanosheets, such as graphene [2][3][4][5][6], graphene oxide (GO) [1,[7][8][9][10], etc. GO has recently attracted substantial interest as a possible intermediate for the preparation of graphene [11][12][13] and metal oxide/graphene nanocomposites [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…GO has recently attracted substantial interest as a possible intermediate for the preparation of graphene [11][12][13] and metal oxide/graphene nanocomposites [14][15][16]. It also has been used to prepare a strong paper-like material owing mainly to their interesting electrical, thermal, mechanical and optical properties [1,8,10,[17][18][19][20][21][22]. The small area of GO sheets results in high inter-sheet contact resistance in the films due to a large amount of intersheet junctions [10,23,24].…”

Section: Introductionmentioning

confidence: 99%

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Facile and size-controllable preparation of graphene oxide nanosheets using high shear method and ultrasonic method

Cai

Sang

Shen

et al. 2017

Journal of Experimental Nanoscience

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The lateral size of the graphene oxide (GO) nanosheets could be controlled by preparation method, and a simple and effective strategy to adjust the lateral size of GO nanosheets by selecting suitable method is presented. The high shear method was introduced to produce GO nanosheets, and the GO nanosheets (few micrometres) prepared by high shear method is about one order of magnitude larger than GO nanosheets (few hundred nanometres) obtained by ultrasonic method, as evidenced by atomic force microscopy. The FTIR, XPS and Raman analysis revealed that there are no distinct differences in composition and functional groups between the GO nanosheets produced by high shear method and ultrasonic method. The cavitation in the procedure of ultrasonic method is favourable for GO exfoliation, but it also could result in damage to GO nanosheets. The shearing force in the process of high shear method is effective for GO delamination with minimal fragmentation. The results indicated that the high shear method proposed in this paper is an efficient exfoliation means to produce single-layer GO nanosheets.

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“…In general, the methodology applied to graphene preparation is based on the Hummers and Offeman 10 (1958) experiment, which uses strong oxidants for the exfoliation of graphite and produces graphene oxide (GO), which subsequently undergoes a process of reduction and formation of graphene or reduced graphene oxide (RGO). Countless studies have proposed changes in the methodology employed by Hummers and Offeman to improve graphene or RGO formation and its stability [11][12][13][14] . The number of stacked sheets defines the material as graphene or RGO since graphene is formed by only one sheet 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Solvothermal Reduction of Graphite Oxide Using Alcohols

2017

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In the present work, we use either ethanol or ethylene glycol as reducing agents through the solvothermal method for graphite oxide reduction. A sulfuric acid treatment before the reduction process was also applied to evaluate its influence on the epoxy group ring-opening reaction. Reduced graphene oxide (RGO) samples were obtained with morphology like crumpled sheets. X-ray diffraction analyses (XRD) showed that the RGO produced via ethylene glycol (EG) reduction followed by treatment with sulfuric acid (RGOEGH) presented the largest d-spacing (0.4114 nm). For reduction with ethanol (RGOEt), the d-spacing value was 0.3883 nm. Infrared spectroscopy (FTIR) results indicated that RGOEt exhibited very low-intensity bands related to oxygenated functional groups, suggesting a high reduction degree, while the sample reduced with EG contained oxygen group bands in the spectrum that disappeared when H 2 SO 4 pretreatment was performed. Thermal gravimetric analyses (TGA) results showed that the samples present high stability and confirmed the reduction process. Moreover, the synthesized RGO sheets were comparable to those produced via more expensive and toxic methodologies.

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High-yield preparation of graphene oxide from small graphite flakes via an improved Hummers method with a simple purification process

Cited by 471 publications

References 31 publications

A hydrogel biosensor for high selective and sensitive detection of amyloid-beta oligomers

A hydrogel biosensor for high selective and sensitive detection of amyloid-beta oligomers

Facile and size-controllable preparation of graphene oxide nanosheets using high shear method and ultrasonic method

Solvothermal Reduction of Graphite Oxide Using Alcohols

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