High water content BSA-PEG hydrogel for controlled release device: Evaluation of the drug release properties

Gayet, Jean-Charles; Fortier, Guy

doi:10.1016/0168-3659(95)00118-2

Cited by 92 publications

(59 citation statements)

References 5 publications

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“…Gayet and Fortier calculated the diffusion coefficient of drugs, having different molecular weight, in BSA-PEG hydrogel. 28 The value of D was found to decrease gradually from 15. The exceptionally slow diffusion of BSA and relatively fast diffusion of water may partially be due to the difference in the respective path of transport.…”

Section: In Vitro Bsa Releasementioning

confidence: 94%

Prolonged zero‐order BSA release from pH‐sensitive hydrogels of poly(AAc‐co‐DMAPMA) having rich nano through micro scale morphology

Das

Mehndiratta

Chattopadhyay

et al. 2009

J of Applied Polymer Sci

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New variety of pH-sensitive hydrogels, having macroporous interior with honey-comb type architecture and continuous skin at the surface, have been developed by single step aqueous copolymerization of acrylic acid (AAc) and N-[3-(dimethylamino)propyl]-methacrylamide (DMAPMA) in different feed ratios at 41 AE 1 C. Interlocked nanogels of $ 300 nm were identified as the building blocks in all of these cylindrical poly(-AAc-co-DMAPMA) matrices (PDMAAc). The gels showed good compressive strength even at a swelling as high as 4330% (mass) at pH 7.0. Morphology of McCoy fibroblast cell line remained unchanged in direct contact with different PDMAAc gels, and cell viability (AESD) was recorded to be in the range of 105 (AE3)% to 87 (AE8)% after 72 h. Bovine serum albumin (BSA) loaded gels were prepared by means of equilibrium partitioning. Loading efficiency of PDMAAc gels has been found to be in the range of 210-277 mg/g dry gel. BSA release from PDMAAc gels at 37 C has been found to follow nonFickian diffusion mechanism in simulated gastric juice (pH 1.2), and Case II transport in simulated intestinal juice (pH 7.4). In vitro study showed that the gels are capable of retaining >95% of the loaded BSA in gastric medium through average gastric emptying period. Again, $ 56% BSA release was recorded in 24 h at pH 7.4, indicating prolonged BSA diffusion in intestinal condition. Constant rate of BSA diffusion was reflected from the release profiles at both the pH. Diffusion exponents also supported the same and indicated for absolute zero-order kinetics at pH 7.4.

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Section: In Vitro Bsa Releasementioning

confidence: 94%

Prolonged zero‐order BSA release from pH‐sensitive hydrogels of poly(AAc‐co‐DMAPMA) having rich nano through micro scale morphology

Das

Mehndiratta

Chattopadhyay

et al. 2009

J of Applied Polymer Sci

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“…Subsequently, other proteins have also been PEGylated in order to prolong their residence time in the blood stream by improving their physical and thermal stability, increasing their protection against proteolysis and decreasing their clearance from the body [9,10]. PEGylated albumin hydrogels for drug delivery applications have also recently been described by two groups [11][12][13], however, in these studies the drug release rates from the hydrogels were dominated by Fickian diffusion and not controlled by the specific affinity of the various tested drugs for the albumin constituent.…”

Section: Introductionmentioning

confidence: 99%

Polymer-conjugated albumin and fibrinogen composite hydrogels as cell scaffolds designed for affinity-based drug delivery

Oss-Ronen

Seliktar

2011

Acta Biomaterialia

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“…However, a downside of biopolymers is their batch-to-batch variation [62][63][64], entailing variation of the physical properties of gels that are formed from them. To avoid this problem, synthetic polymers like polyethylene glycol [65][66][67], polyhydroxyethylmethacrylate [68][69][70], and polyglycerol [71][72][73] can be used to substitute biopolymers. In their native form, these polymers are incapable of forming hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Supramolecular Hydrogels as Materials for Medicine

Hackelbusch

Seiffert

2014

In-Situ Gelling Polymers

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This chapter describes some recent research in the field of supramolecular polymeric hydrogels. Eight examples are discussed that represent a small view of the plethora of these advanced functional materials. The examples described herein exhibit tunable physicochemical properties that allow for adjustment towards targeted applications in the biomedical field, including protein immobilization, tissue engineering, drug delivery, and dermocosmetics. The highly adaptive supramolecular polymeric hydrogels are likely to have a bright future as materials for medicine.

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High water content BSA-PEG hydrogel for controlled release device: Evaluation of the drug release properties

Cited by 92 publications

References 5 publications

Prolonged zero‐order BSA release from pH‐sensitive hydrogels of poly(AAc‐co‐DMAPMA) having rich nano through micro scale morphology

Prolonged zero‐order BSA release from pH‐sensitive hydrogels of poly(AAc‐co‐DMAPMA) having rich nano through micro scale morphology

Polymer-conjugated albumin and fibrinogen composite hydrogels as cell scaffolds designed for affinity-based drug delivery

Polymeric Supramolecular Hydrogels as Materials for Medicine

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