High-Voltage Pulsed Current Stimulation Enhances Wound Healing in Diabetic Rats by Restoring the Expression of Collagen, &lt;i&gt;α&lt;/i&gt;-Smooth Muscle Actin, and TGF-&lt;i&gt;β&lt;/i&gt;1

Kim, Tae Hoon; Cho, Hwi-Young; Lee, Suk Min

doi:10.1620/tjem.234.1

Cited by 26 publications

(35 citation statements)

References 18 publications

(19 reference statements)

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“…DC, AC, and PC have exhibited highly differential effects on fibroblasts in an in vitro study, where at high intensity and frequencies, the PC maximally downregulates collagen I and have a lower cytotoxic effect than AC and DC 13. At the wound site, enhanced fibroblast activities with DC, PC, and HVPC have also been reported in vivo, resulting in an increased fibroblast number,29,39 collagen synthesis,13,29,33,36,38 myofibroblast creation, and tensile strength 29. HVPC on diabetic rats has shown accelerated wound healing and restoration of the expression levels of collagen I and transforming growth factor, suggesting reactivation of the fibroblast activities 33.…”

Section: Es Cellular and Molecular Mechanismsmentioning

confidence: 96%

A current affair: electrotherapy in wound healing

Hunckler¹,

Mel²

2017

JMDH

111

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New developments in accelerating wound healing can have immense beneficial socioeconomic impact. The wound healing process is a highly orchestrated series of mechanisms where a multitude of cells and biological cascades are involved. The skin battery and current of injury mechanisms have become topics of interest for their influence in chronic wounds. Electrostimulation therapy of wounds has shown to be a promising treatment option with no-device-related adverse effects. This review presents an overview of the understanding and use of applied electrical current in various aspects of wound healing. Rapid clinical translation of the evolving understanding of biomolecular mechanisms underlying the effects of electrical simulation on wound healing would positively impact upon enhancing patient’s quality of life.

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Section: Es Cellular and Molecular Mechanismsmentioning

confidence: 96%

A current affair: electrotherapy in wound healing

Hunckler¹,

Mel²

2017

JMDH

111

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“…The previous study revealed that ES could reduce inflammation, improve blood flow, reduce the bacterial burden, reduce pain and edema, decrease muscle spasms, and improve TGF-β1, collagen-I, and muscle contraction (Demir, Balay and Kirnap, 2004;Sebastian et al, 2011;Kim, Cho and Lee, 2014;Torkaman, 2014). Recent research by the author has shown that compared with the standard treatment, wounds treated with ES showed a reduction in inflammation and an increase in re-epithelialisation (Sari, Sutrisna and Hartono, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…A reduction in inflammation following ES in diabetic ulcers might be due to the ability of ES to enhance phagocytosis (Cho et al, 2000). The improvement of reepithelialization might be due to the ability of ES to promote keratinocyte migration (Kim, Cho and Lee, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Following an injury to the skin, a low current flows between the skin and underlying tissue, which is called the current of injury. This is important during the wound healing process (Kim, Cho and Lee, 2014). The electric current which is used in ES is a low current (microAmpere, μA).…”

Section: Introductionmentioning

confidence: 99%

“…Results of studies both in vitro and in vivo reveal that ES improves the healing process by promoting keratinocyte migration, improving wound perfusion, stimulating collagen synthesis (Kim, Cho and Lee, 2014), and inducing angiogenesis (Liebano and Machado, 2014). (Liebano and Machado, 2014).…”

Section: Introductionmentioning

confidence: 99%

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A Comparative Study of the Effects of Vibration and Electrical Stimulation Therapies on the Acceleration of Wound Healing in Diabetic Ulcers

Sari¹,

Saryono²,

Sutrisna³

et al. 2017

J. Ners

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Introduction: Diabetic ulcers accompanied by ischemia is difficult to treat. Such ulcers require therapy that can improve the blood flow. Previous studies have revealed that two therapies could improve blood flow and accelerate the healing of diabetic ulcers; vibration and electrical stimulation (ES). However, it is unknown which of these two therapies is best at accelerating wound healing in diabetic ulcers. The purpose of this study was to compare both therapies in relation to accelerating the wound healing of diabetic ulcers. Methods: This study was an experimental study involving diabetic rats. The rats were divided into two groups: vibration and ES. Vibration and ES were applied for 10 minutes per day for 7 days. Wound size, inflammation, intensity of fibroblast infiltration, area of necrosis and degree of re-epithelialisation were compared. The difference in wound size was analysed using an independent t-test, while the histological data were analysed using a Mann-Whitney U-test. Results: On day 5 onwards, there was a thin slough in the ES group which was not present in the vibration group. Day 4 onwards and the wound size was significantly smaller in the vibration group than in the ES group. The intensity of inflammation was significantly less, and the degree of fibroblast infiltration was significantly higher in the vibration group compared with the ES group. Re-epithelialisation was more advanced in the vibration group than the ES group. Conclusions: Our study revealed that wound healing in diabetic ulcers following vibration was better than after ES. We suggest that nurses should use vibration rather than ES in clinical settings.

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Electrotherapy for urethral modulation: Are extracellular matrix molecules and growth factors potential targets?

Feitosa

Bortolini

Salerno

et al. 2021

Neurourology and Urodynamics

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Aims: To evaluate the expression of genes and proteins involved in the urethral components: vessels, nerves, and extracellular matrix, in female rats after trauma by vaginal distension (VD) and after electrical stimulation therapy (electrotherapy). Methods: We analyzed the urethras of three groups of 18 female rats 30 days posttrauma by VD: control (no interventions); trauma (animals that had VD); and electrotherapy group (those that had VD and were treated with electrical stimulation). We compared the expression of vascular endothelial growth factor (VEGF), nerve growth factor (NGF), collagen types I and III (COL1a1 and COL3a1), and lysyl-oxidase like 1 (LOXL1) among the groups. Real-time reverse transcription-polymerase chain reaction, Western blot, and immunohistochemistry were used for molecule quantification. We used the Kruskal-Wallis test and analysis of variance for statistical analyses with p < 0.05 for significance.Results: The COL1a1 gene expression was higher in the electrotherapy group than the trauma group (p = 0.036). COL3a1, VEGF, NGF, LOXL1 messenger RNA (mRNA) expression did not differ among the groups (p ≥ 0.05). COL1a1, COL3a1, VEGF, NGF, LOXL1 protein levels did not significantly differ among the groups (p ≥ 0.05) in Western blot analysis or immunohistochemistry assays. Conclusions: Electrotherapy caused a long-term increase in the COL1a1 mRNA level but did not change COL1a1 protein expression or VEGF, NGF, COL3a1, and LOXL1 genes and proteins in the urethras of rats after trauma by VD.

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High-Voltage Pulsed Current Stimulation Enhances Wound Healing in Diabetic Rats by Restoring the Expression of Collagen, <i>α</i>-Smooth Muscle Actin, and TGF-<i>β</i>1

Cited by 26 publications

References 18 publications

A current affair: electrotherapy in wound healing

A current affair: electrotherapy in wound healing

A Comparative Study of the Effects of Vibration and Electrical Stimulation Therapies on the Acceleration of Wound Healing in Diabetic Ulcers

Electrotherapy for urethral modulation: Are extracellular matrix molecules and growth factors potential targets?

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