High Triglyceride-Glucose Index with Renal Hyperfiltration and Albuminuria in Young Adults: The Korea National Health and Nutrition Examination Survey (KNHANES V, VI, and VIII)

Oh, Deuk-Ja; Park, Sang Ho; Lee, Seo-Young; Yang, Eunji; Park, Hyeong Cheon; Jhee, Jong Hyun

doi:10.3390/jcm11216419

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…Liu et al (16) found that the TyG index was proportional to urinary albumin-to-creatinine ratio (UACR) in adults. Proteinuria was particularly associat-ed with high TyG index in RHF patients (17). Li et al found that the TyG index showed a positive correlation with the kidney injury in middle-aged and elderly people with WRF (18).…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study

Jin,

Xiao,

et al. 2024

J Med Biochemistry

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Background: The relationship between triglyceride glucose (TyG) index and the incidence of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) is unclear. This study aims to explore the relationship between the two. Methods: Participants were enrolled from Medical Information Mart for Intensive Care IV (MIMICIV) and grouping of subjects based on the quartile interval of the TyG index. With the presence of AKI as the main outcome, a logistic regression model was constructed. The correlation of the TyG index with the results obtained was examined by using a restricted cubic spline (RCS) model. Results: Among the 1,101 AMI participants, 64.7% were male patients and the overall incidence rate of AKI was 37.1%. The results of multivariate Logistic regression analysis (LRA) revealed independent correlation of the TyG index with increased AKI risk (odds ratio (OR) = 2.23; confidence interval (CI) = 1.59 to 3.17; P < 0.001). Q4 (9.5-12.208) in the TyG index quartile was independently correlated with increased AKI risk (OR = 2.99, 95% CI = 1.64 to 5.46, P < 0.001). The RCS model showed that the AKI risk increased linearly as the TyG index increased (P=0.313). Conclusion: In patients with AMI, the incidence of TyG and AKI is closely related. Nevertheless, further studies are needed to verify the finding.

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Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study

Jin,

Xiao,

et al. 2024

J Med Biochemistry

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“…adults with higher TyG index have a higher urinary albumin to creatinine ratio (UACR) [ 22 ]. According to a Korean study, proteinuria is particularly associated with high TyG index in patients with RHF [ 23 ]. Professor Li’s research on TyG index and kidney injury in middle-aged and elderly people has shown that there is a positive and independent relationship between the TyG index and worsening renal function [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and AKI in ICU patients based on MIMICIV database: a cross-sectional study

Jin

Zhang

2023

Renal Failure

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Background Methods for early prediction of the occurrence of acute kidney injury (AKI) were limited. The relationship between triglyceride glucose index (TyG) and the incidence of acute kidney injury in ICU patients is unclear. This study aims to explore the relationship between the two. Methods Based on their TyG index, participants from the Intensive Care Medical Information Market IV (MIMIC-IV) were divided into quartiles. A logistic regression model was constructed based on the risk of acute kidney injury as the main outcome, in order to detect a potential relationship that may exist between the TyG index and acute kidney injury in ICU patients. Finally, in order to confirm the relationship existing between the TyG index and the results, a restricted cubic spline model was used. Results In total, 54,263 patients were involved in our present study, of whom 48.2% were male. The occurrence of acute kidney injury was 25.1%. An independent relationship was observed between the TyG index and an increased risk of acute kidney injury through multivariate logistic regression analysis (OR, 1.28 [95% CI 1.22–1.35] p < 0.001). Q4 (5.344–9.911) of the TyG index quartiles was independently associated with an increase in the risk of acute kidney injury (OR, 1.43 [95% CI (1.32–1.54)] p < 0.001). Through the restricted cubic spline regression model, the risk of acute kidney injury was also demonstrated to increase linearly with an increase in the TyG index. Conclusion The triglyceride glucose index is related to the risk of acute kidney injury in ICU patients. In the future, in order to further validate this finding, larger prospective studies are needed.

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“…The triglyceride-glucose (TyG) index, calculated using fasting triglyceride (TG) and fasting plasma glucose (FPG) levels, has become a straightforward surrogate marker for IR [7]. Multiple investigations have demonstrated a positive association between elevated TyG index values and the incidence rates of hypertension, HF, coronary artery disease, and chronic kidney disease (CKD) [8][9][10][11][12]. Moreover, the TyG index has demonstrated its reliability and convenience as a prognostic indicator for adverse outcomes in patients with kidney disease [13,14].…”

Section: Introductionmentioning

confidence: 99%

Association between the triglyceride glucose (TyG) index and the risk of acute kidney injury in critically ill patients with heart failure: analysis of the MIMIC-IV database

Yang,

Gong,

Kan

et al. 2023

Cardiovasc Diabetol

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Background Insulin resistance (IR) can be effectively assessed using the dependable surrogate biomarker triglyceride-glucose (TyG) index. In various critical care contexts, like contrast-induced acute kidney injury (AKI), an elevated TyG index has demonstrated a robust correlation with the incidence of AKI. Nonetheless, the potential of the TyG index to predict AKI in critically ill patients with heart failure (HF) remains uncertain. Methods A cohort of participants was non-consecutively selected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and divided into quartiles based on their TyG index values. The incidence of AKI was the primary outcome. The secondary endpoint was in-hospital mortality within both the whole study population and the subset of AKI patients. The use of the renal replacement therapy (RRT) which represented the progression of AKI severity was also included as a secondary endpoint representing renal outcome. A restricted cubic splines model and Cox proportional hazards models were utilized to evaluate the association of TyG index with the risk of AKI in patients with HF in a critical condition. Kaplan-Meier survival analysis was employed to estimate primary and secondary endpoint disparities across groups differentiated by their TyG index. Results This study included a total of 1,393 patients, with 59% being male. The incidence of AKI was 82.8%. Cox proportional hazards analyses revealed a significant association between TyG index and the incidence of AKI in critically ill patients with HF. The restricted cubic splines model illustrated the linear relationship between higher TyG index and increased risk of AKI in this specific patient population. Furthermore, the Kaplan-Meier survival analyses unveiled statistically significant differences in the use of RRT across the subset of AKI patients based on the quartiles of the TyG index. Conclusions The results highlight the TyG index as a robust and independent predictor of the incidence of AKI and poor renal outcome in patients with HF in a critical condition. However, further confirmation of causality necessitates larger prospective studies.

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High Triglyceride-Glucose Index with Renal Hyperfiltration and Albuminuria in Young Adults: The Korea National Health and Nutrition Examination Survey (KNHANES V, VI, and VIII)

Cited by 4 publications

References 43 publications

Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study

Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study

Association between triglyceride-glucose index and AKI in ICU patients based on MIMICIV database: a cross-sectional study

Association between the triglyceride glucose (TyG) index and the risk of acute kidney injury in critically ill patients with heart failure: analysis of the MIMIC-IV database

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