Association between triglyceride-glucose index and AKI in ICU patients based on MIMICIV database: a cross-sectional study

Jin, Zihan; Zhang, Kai

doi:10.1080/0886022x.2023.2238830

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…In terms of kidney disease, Yang et al found a significant linear relationship between TyG index levels and the risk of AKI in patients with critical heart failure, and an increase in TyG index predicted a higher RRT usage rate in patients with heart failure and AKI [ 18 ]. Similarly, Jin et al found a higher TyG index in critically ill patients was significantly correlated with increased susceptibility to AKI through a large cross-sectional study [ 28 ]. In addition, the relationship between TyG index and chronic renal deterioration has also been concerned.…”

Section: Discussionmentioning

confidence: 99%

Association of triglyceride glucose index with the risk of acute kidney injury in patients with coronary revascularization: a cohort study

Shi,

Duan,

Liu

et al. 2024

Diabetol Metab Syndr

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Background The triglyceride glucose (TyG) index is a novel and reliable alternative marker for insulin resistance. Previous studies have shown that TyG index is closely associated with cardiovascular outcomes in cardiovascular diseases and coronary revascularization. However, the relationship between TyG index and renal outcomes of coronary revascularization is unclear. The purpose of this study was to investigate the correlation between TyG index and the risk of acute kidney injury (AKI) in patients with coronary revascularization. Methods A retrospective cohort study was conducted to select eligible patients with coronary revascularization admitted to ICU in the medical information mart for intensive care IV (MIMIC-IV). According to the TyG index quartile, these patients were divided into four groups (Q1-Q4). The primary endpoint was the incidence of AKI, and secondary endpoints included 28-day mortality and the rate of renal replacement therapy (RRT) use in the AKI population. Multivariate Cox regression analysis and restricted cubic splines (RCS) were used to analyze TyG index association with AKI risk. Kaplan-Meier survival analysis was performed to assess the incidence of endpoints in the four groups. Results In this study, 790 patients who underwent coronary revascularization surgery were included, and the incidence of AKI was 30.13%. Kaplan-Meier analysis showed that patients with a high TyG index had a significantly increased incidence of AKI (Log-rank P = 0.0045). Multivariate Cox regression analysis showed that whether TyG index was a continuous variable (HR 1.42, 95% CI 1.06–1.92, P = 0.018) or a categorical variable (Q4: HR 1.89, 95% CI 1.12–3.17, P = 0.017), and there was an independent association between TyG index and AKI in patients with coronary revascularization. The RCS curve showed a linear relationship between higher TyG index and AKI in this particular population (P = 0.078). In addition, Kaplan-Meier analysis showed a significantly increased risk of RRT application in a subset of AKI patients based on quartiles of TyG index (P = 0.029). Conclusion TyG index was significantly associated with increased risk of AKI and adverse renal outcomes in patients with coronary revascularization. This finding suggests that the TyG index may be useful in identifying people at high risk for AKI and poor renal outcomes in patients with coronary revascularization.

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Section: Discussionmentioning

confidence: 99%

Association of triglyceride glucose index with the risk of acute kidney injury in patients with coronary revascularization: a cohort study

Shi,

Duan,

Liu

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

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Triglyceride-glucose index predicts sepsis-associated acute kidney injury and length of stay in sepsis: A MIMIC-IV cohort study

Fang,

Xiong,

Shang

et al. 2024

Heliyon

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The Triglyceride-glucose Index and Acute Kidney Injury Risk in Critically Ill Patients with Coronary Artery Disease

Zhang,

Li,

et al. 2024

Preprint

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Background: The triglyceride-glucose (TyG) index, proven a reliable and simple surrogate of insulin resistance, has shown potential associations with cardiovascular outcomes and renal diseases. This research delved into the utility of the TyG index in predicting the risk of acute kidney injury (AKI) in patients with coronary artery disease (CAD), an area not extensively covered in existing literature. Methods: A cohort of patients with CAD was recruited from the intensive care unit (ICU), and categorized into quartiles based on their TyG index. The primary outcome was AKI incidence, and the secondary outcome was renal replacement therapy (RRT). Scatterplot histograms, cox proportional hazards models, Kaplan-Meier survival curves, and restricted cubic splines were employed to investigate the association between the TyG index and the risk of AKI in patients with CAD. Results: A total of 1,501 patients were enrolled in this study, predominantly male (61.56%), with a median age of 69.80 years. The AKI incidence was 67.22% among all patients, with the AKI stages increased with higher TyG levels (P for trend < 0.001). The Kaplan-Meier survival analyses demonstrated statistically significant differences in AKI incidence and RRT application throughout the entire cohort, stratified by the TyG index quartiles (P <0.001). Additionally, the restricted cubic spline analysis revealed a nearly linear association between the TyG index and the risk of AKI (Pfor non-linear = 0.507). Both multivariate Cox proportional hazards analyses (HR 1.60; 95% CI 1.32-1.95; P <0.001) and multivariate logistic regression analyses (OR 2.46; 95% CI 1.71-3.56; P <0.001) showed that the elevated TyG index was significantly related to AKI incidence. The association between TyG index and the risk of AKI is more significant in patients without diabetes (HR 1.27; 95% CI 1.14-1.42; P <0.001), compared to patients with diabetes (Pfor interaction = 0.013). Conclusions: In summary, the TyG index emerged as a reliable predictor for the occurrence of AKI in CAD patients during ICU stay. Furthermore, it is also anticipated to serve as a valuable indicator for non-diabetic patients in predicting the incidence of AKI.

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Association between triglyceride-glucose index and AKI in ICU patients based on MIMICIV database: a cross-sectional study

Cited by 4 publications

References 39 publications

Association of triglyceride glucose index with the risk of acute kidney injury in patients with coronary revascularization: a cohort study

Association of triglyceride glucose index with the risk of acute kidney injury in patients with coronary revascularization: a cohort study

Triglyceride-glucose index predicts sepsis-associated acute kidney injury and length of stay in sepsis: A MIMIC-IV cohort study

The Triglyceride-glucose Index and Acute Kidney Injury Risk in Critically Ill Patients with Coronary Artery Disease

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