High Titers of Chlamydia trachomatis Antibodies in Brazilian Women with Tubal Occlusion or Previous Ectopic Pregnancy

Machado, Adriana Rodrigues; Guimarães, Eleuse M B; Sakurai, Emília; Fioravante, F. C. R.; Amaral, Waldemar Naves do; Alves, M. F. C.

doi:10.1155/2007/24816

Cited by 29 publications

(28 citation statements)

References 26 publications

(30 reference statements)

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“…The C. trachomotis infection is the most common sexually transmitted bacterial infection worldwide, especially among young adults [5]. The chlamydial infection produces less severe symptoms than other sexually transmitted diseases [6].…”

Section: Introductionmentioning

confidence: 99%

Association of the Serum Anti-chlamydial Antibodies with Tubal Infertility

Surana

Rastogi²,

Nirwan³

2012

JCDR

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Background: Infertility is increasingly becoming a significant health problem in many areas of the world. The infection which is caused by Chlamydia trachomatis is a major cause of tubal factor infertility secondary to salpingitis. However, the data which pertains to infertility attributed to the C. trachomatis infection is limited in India. Aims:To evaluate the chlamydial infection in women who suffered from infertility and to investigate the possible role of the chlamydia serology as a screening test for tubal infertility.Method: This study was aimed at evaluating the chlamydial infection in fifty women with primary infertility and at investigating the possible role of the chlamydial serology as a screening test for tubal infertility, by the detection of the anti-chlamydial IgM antibodies by using E.L.I.S.A. Setting and Design:The present prospective study was carried out at a tertiary care hospital in north India. Results:In this study, a high seropositivity (60%) for the antichlamydial antibody was observed. 52% females showed bilateral tubal blockage, while the most common site of the blockage was the ampullary portion (36%). Conclusion:These findings highlighted a strong correlation between the tubal factor infertility and the antichlamydial antibodies. It also stressed on the need of the screening of infertile women for C. trachomatis with laboratory investigations, which could provide a rapid and specific diagnosis so that early therapeutic interventions could be instituted.Ashish surAnA, VijAylAtA rAstogi, Prem singh nirWAn

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Section: Introductionmentioning

confidence: 99%

Association of the Serum Anti-chlamydial Antibodies with Tubal Infertility

Surana

Rastogi²,

Nirwan³

2012

JCDR

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“…The World Health Organization estimates that approximately 50 million cases of infection by Chlamydia trachomatis occur per year worldwide [2]. Chlamydia trachomatis infection of the genital tract can cause inflammatory pelvic disease, venereal lymphogranuloma, urethritis, cervicitis, salpingitis, bartholinitis, endometritis, tubarian infertility and ectopic pregnancy [2][3][4]. The health costs due to complications caused by this type of infection are elevated.…”

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confidence: 99%

“…Consequently, these infectious agents can be considered microorganisms that are well adapted to the human body, because they can grow without causing strong responses from the organism, which is the reason it is difficult to diagnose such infections [6]. This peculiarity retards treatment, allowing cases of genital infection to propagate to the upper genital tract, causing endometritis and salpingitis [2][3][4].…”

mentioning

confidence: 99%

Chlamydia infection in patients with and without cervical intra-epithelial lesions tested by real-time PCR vs. direct immunofluorescence

Oliveira¹,

Amorim²,

Souza³

et al. 2008

Braz J Infect Dis

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This study compares the detection rates of Chlamydia trachomatis by two techniques, direct immunofluorescence (IMF) and real time polymerase chain reaction (PCR), in patients with and without intra-epithelial cervical lesions (SIL) in Recife. We conducted a transversal study involving 35 women with SIL and 35 without SIL attended at Ambulatório Especializado da Mulher, Recife, Brazil. They were tested for Chlamydia trachomatis using two techniques, direct IMF or real time PCR. The rates of Chlamydia trachomatis detection were compared and the association with intra-epithelial cervical lesions was determined using the chi-square test at a 5% level of significance. Concordance between the tests was evaluated using kappa. The global prevalence of Chlamydia infection was 47.1% by direct IMF and 58.6% by real time PCR. A significant association was observed between Chlamydia diagnosis and presence of intra-epithelial cervical lesions, with about 80% positive results by direct IMF and 77.1% by real time PCR. However, the detected rate of infection with Chlamydia trachomatis was significantly greater in patients without intra-epithelial cervical lesions tested by real time PCR (40%) when compared to direct IMF (14.3%). The concordance between the tests was weak, with a kappa coefficient of 0.4. Both real time PCR and direct IMF detected elevated rates of Chlamydia infection in patients with intra-epithelial cervical lesions (80%) but the tests were discordant when patients without cervical lesions were tested, possibly because sensitivity of real time PCR is greater.

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“…Historically, serological testing has been used in investigation of women with pelvic inflammatory disease [113], ectopic pregnancies [114], recurrent miscarriages [12] and tubal infertility [115]. Despite this, serological testing to identify Chlamydia specific antibodies is not considered to be useful in the diagnosis of genital tract infection, for a number of reasons.…”

Section: Indirect Detectionmentioning

confidence: 99%