High Throughput Screening in Agrochemical Research

Tietjen, Klaus; Drewes, M. W.; Stenzel, K.

doi:10.2174/138620705774575300

Cited by 38 publications

(28 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tietjen et al have reviewed the applications of omics technologies to the conventional agrochemical development method. 7) The influence of omics methods can already be observed at the IUPAC meeting in Kobe this summer with the theme "Evolution for Crop Protection, Public Health, and Environmental Safety." Platform sessions include: Genomics, Proteomics and Metabolomics" and "Drug Design Based Upon Agrogenomics" with a presentation on a "Proposal for SAR-omics as a paradigm for lead evolution in drug design."…”

Section: )mentioning

confidence: 99%

“…6) One approach to address these shifting research trends is through the application of omics technologies. 7) In agrochemistry, the use of genomics to identify suitable product candidates and the introduction of combinatorial chemistry to produce compounds for biological screening were identified as important developments over the last 10 years. 5) For example, it is expected that functional genomics will be useful in the identification of novel targets for herbicide development and aid in the development of assays systems for discovering lead compounds.…”

Section: The Omicization Of Agrochemical Researchmentioning

confidence: 99%

“…7) Used as fingerprint methods, these enable a fast and reliable detection of known modes of action and a clear identification and classification of unknown modes of action. For example, artificial neural network analysis of 1 H NMR spectra was used to classify changes in total metabolic profile in aqueous plant extracts of corn (Zea mays) caused by herbicide application.…”

Section: )mentioning

confidence: 99%

“…Taken together, these broad-based omics approaches could potentially address one of the current main issues in agrochemistry, a lack of novel targets. 5,7) One of the initial areas of fruitful research has been in the application of proteomics to examine the effects of herbicide treatment upon target organism proteins. For example, treatment of the grapevine (Vitis vinifera L.) with the herbicide flumioxazin resulted in 33 distinct proteins displaying a differential expression pattern.…”

Section: )mentioning

confidence: 99%

See 3 more Smart Citations

The omicization of agrochemical research

Wheelock¹,

Miyagawa²

2006

J. Pestic. Sci.

View full text Add to dashboard Cite

Section: )mentioning

confidence: 99%

Section: The Omicization Of Agrochemical Researchmentioning

confidence: 99%

Section: )mentioning

confidence: 99%

Section: )mentioning

confidence: 99%

See 2 more Smart Citations

The omicization of agrochemical research

Wheelock¹,

Miyagawa²

2006

J. Pestic. Sci.

View full text Add to dashboard Cite

“…18). High-throughput screening in agrochemical discovery has been reviewed recently (Tietjen et al, 2005;Drewes et al, 2012). Another approach to discover new herbicidal precepts consists of the systematic analysis of plant gene functions (Lein et al, 2004).…”

Section: New Discovery Approachesmentioning

confidence: 99%

Herbicides as Weed Control Agents: State of the Art: II. Recent Achievements

et al. 2014

View full text Add to dashboard Cite

In response to changing market dynamics, the discovery of new herbicides has declined significantly over the past few decades and has only seen a modest upsurge in recent years. Nevertheless, the few introductions have proven to be interesting and have brought useful innovation to the market. In addition, herbicide-tolerant or herbicide-resistant crop technologies have allowed the use of existing nonselective herbicides to be extended into crops. An increasing and now major challenge is being posed by the inexorable increase in biotypes of weeds that are resistant to herbicides. This problem is now at a level that threatens future agricultural productivity and needs to be better understood. If herbicides are to remain sustainable, then it is a must that we adopt diversity in crop rotation and herbicide use as well as increase the use of nonchemical measures to control weeds. Nevertheless, despite the difficulties posed by resistant weeds and increased regulatory hurdles, new screening tools promise to provide an upsurge of potential herbicide leads. Our industry urgently needs to supply agriculture with new, effective resistance-breaking herbicides along with strategies to sustain their utility.Only a few companies are significantly pursuing herbicide discovery in the 21st century. Most of these have combined seed and traits businesses, since fees for traits constitute a considerable part of the income of agrochemical companies today. In concert with a review of the historical perspectives of herbicide research (Kraehmer et al., 2014), we provide here a short description of the current major research activities within the remaining 21st century agrochemical companies. After an overview of the chemicals that have entered the market in the 21st century, we provide a brief summary of the current nature of the weed-resistant herbicide problem. We then go on to summarize breedingassisted and transgenic approaches toward the improvement of crop selectivity through the delivery of so-called herbicide-tolerant (HT) or herbicide-resistant crops, and conclude with a discussion of the new herbicide discovery screening tools that have been employed since the year 2000 and prospects for the future. MAJOR CHEMICAL TRENDS AFTER 2000Several new compounds have entered the herbicide market in recent years. Although not representing new modes of action (MoAs), they have increased the number of tools available for farmers to use to control weeds. Even in known and older herbicidal classes, new, interesting, and marketable molecules have been discovered. For example, and perhaps surprising given the relative age of the class of herbicides, new (after 2000) acetolactate synthase (ALS) inhibitors have provided solutions for farmers that can be regarded as real innovations. One of them is mesosulfuron-methyl (Fig. 1), a sulfonylurea herbicide that, when combined with iodosulfuron-methyl sodium, has broad-spectrum postemergence grass weed control at dose rates of 4.5 to 15 g active ingredient (a.i.) ha 21 (Safferling, 2005). Another ...

show abstract

Combinatorial Chemistry Library Design

Klein¹,

Lindell²

2013

Plant Chemical Biology

View full text Add to dashboard Cite

High Throughput Screening in Agrochemical Research

Cited by 38 publications

References 39 publications

The omicization of agrochemical research

The omicization of agrochemical research

Herbicides as Weed Control Agents: State of the Art: II. Recent Achievements

Combinatorial Chemistry Library Design

Contact Info

Product

Resources

About