High‐Throughput Method for Determining Modulus of Polymer Blends

Simon, Carl G.; Eidelman, Naomi; Deng, Yongming; Washburn, Newell R.

doi:10.1002/marc.200400395

Cited by 30 publications

(10 citation statements)

References 29 publications

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“…The surface morphology can be characterized by microscopy techniques including optical and confocal microscopy. In addition, depth-sensing indentation (DSI) testing or nanoindentation is well suited for mechanical property measurements [4,[6][7][8] and has been demonstrated to be useful in the characterization of dental composites, ceramics and alloys [9,10]. Recently, the indenter probe has been used to produce well-controlled scratches with either a constant load or progressively increasing load (progressiveload scratch) with the resultant scratches characterized by confocal microscopy or light scattering [11,12].…”

Section: Introductionmentioning

confidence: 99%

Effects of filler type and content on mechanical properties of photopolymerizable composites measured across two-dimensional combinatorial arrays

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Effects of filler type and content on mechanical properties of photopolymerizable composites measured across two-dimensional combinatorial arrays

et al. 2009

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“…The convection‐driven blending of two components in our microchannel could enable the rapid synthesis of combinatorial material libraries without sophisticated equipment (Potyrailo et al, 2003; Anderson et al, 2005; Hook et al, 2010) or uncontrollable mixing/deposition procedures (Simon et al, 2004, 2005). In addition, our simple microchannel design consumes only small amounts of reagent (less than 10 µL of each solution), important for reducing the costs associated with screening rare or costly materials (i.e., peptide‐based or rare metal‐based materials).…”

Section: Discussionmentioning

confidence: 99%

Microfluidic synthesis of composite cross‐gradient materials for investigating cell–biomaterial interactions

Guo

et al. 2010

Biotech & Bioengineering

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Combinatorial material synthesis is a powerful approach for creating composite material libraries for the high-throughput screening of cell-material interactions. Although current combinatorial screening platforms have been tremendously successful in identifying target (termed "hit") materials from composite material libraries, new material synthesis approaches are needed to further optimize the concentrations and blending ratios of the component materials. Here we employed a microfluidic platform to rapidly synthesize composite materials containing crossgradients of gelatin and chitosan for investigating cell-biomaterial interactions. The microfluidic synthesis of the cross-gradient was optimized experimentally and theoretically to produce quantitatively controllable variations in the concentrations and blending ratios of the two components. The anisotropic chemical compositions of the gelatin/chitosan cross-gradients were characterized by Fourier transform infrared spectrometry and X-ray photoelectron spectrometry. The three-dimensional (3D) porous gelatin/chitosan cross-gradient materials were shown to regulate the cellular morphology and proliferation of smooth muscle cells (SMCs) in a gradientdependent manner. We envision that our microfluidic cross-gradient platform may accelerate the material development processes involved in a wide range of biomedical applications.

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“…This is generally realized by material arrays (microarrays or microtiter plates) in combination with sensor arrays [ 79 ] and/or imaging techniques (FTIR microscopes) that directly deliver compositional maps ( Figure ). [ 80 ]…”

Section: Methods Of High‐throughput and Combinatorial Studiesmentioning

confidence: 99%

High‐Throughput and Combinatorial Approaches for the Development of Multifunctional Polymers

Baudis

Behl

2021

Macromol. Rapid Commun.

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High-throughput (HT) development of new multifunctional polymers is accomplished by the combination of different HT tools established in polymer sciences in the last decade. Important advances are robotic/HT synthesis of polymer libraries, the HT characterization of polymers, and the application of spatially resolved polymer library formats, explicitly microarray and gradient libraries. HT polymer synthesis enables the generation of material libraries with combinatorial design motifs. Polymer composition, molecular weight, macromolecular architecture, etc. may be varied in a systematic, fine-graded manner to obtain libraries with high chemical diversity and sufficient compositional resolution as model systems for the screening of these materials for the functions aimed. HT characterization allows a fast assessment of complementary properties, which are employed to decipher quantitative structure-properties relationships. Moreover, these methods facilitate the HT determination of important surface parameters by spatially resolved characterization methods, including time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy. Here current methods for the high-throughput robotic synthesis of multifunctional polymers as well as their characterization are presented and advantages as well as present limitations are discussed.

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High‐Throughput Method for Determining Modulus of Polymer Blends

Cited by 30 publications

References 29 publications

Effects of filler type and content on mechanical properties of photopolymerizable composites measured across two-dimensional combinatorial arrays

Effects of filler type and content on mechanical properties of photopolymerizable composites measured across two-dimensional combinatorial arrays

Microfluidic synthesis of composite cross‐gradient materials for investigating cell–biomaterial interactions

High‐Throughput and Combinatorial Approaches for the Development of Multifunctional Polymers

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