High thoracic sympathetic block improves coronary microcirculation disturbance in rats with chronic heart failure

Sun, Guozhen; Liu, Fengqi; Xiu, Chunhong

doi:10.1016/j.mvr.2018.11.013

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…The increasing prevalence of diabetes and CHF as comorbidities poses a complex therapeutic niche [75,76]. As standalone pathologies, both diabetes [30,35,48,69,70,77,78] and CHF [66][67][68][79][80][81] present with modest microvascular rarefaction, and those suffering with both are likely to have more pronounced rarefaction. To further complicate matters the metabolic response to these isolated pathologies is mixed, with evidence that diabetes may preserve [82] or increase oxidative demand of muscle, while CHF tends to present with a reduced oxidative capacity in locomotor muscles [83,84].…”

Section: Exercise-induced Angiogenesis In Diseasementioning

confidence: 99%

Exercise-mediated angiogenesis

Kissane

Egginton

2019

Current Opinion in Physiology

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Highlights Skeletal muscle is heterogeneous in capillary distribution and oxidative demand  The extent of capillarisation is a key predictor of muscle aerobic capacity  Exercise-induced angiogenesis is driven by both chemical and mechanical signals  Simply increasing the number of capillaries may not be an optimal response  Understanding spatial distribution will facilitate the design of specific exercise regimes

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Section: Exercise-induced Angiogenesis In Diseasementioning

confidence: 99%

Exercise-mediated angiogenesis

Kissane

Egginton

2019

Current Opinion in Physiology

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“…As an example, it can be applied to improve coronary microcirculation in rats with chronic heart failure. Sun and his colleagues reported that high thoracic sympathetic block improved myocardial capillary spasm and growth 18 . TSNB can also be applied as a predictive procedure for compensatory hyperhidrosis before sympathectomy in primary hyperhidrosis, based on the effect of sympathetic block on increasing skin perfusion and temperature through vasodilation at the anesthetized sites 10 , 11 , 19 , 20 .…”

Section: Discussionmentioning

confidence: 99%

Use of thoracoscopy for thoracic sympathetic nerve block in primary hyperhidrosis

Han

Ahn

Jeong

et al. 2023

Sci Rep

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Thoracic sympathetic nerve block (TSNB) has been widely used in the treatment of neuropathic pain. To reduce block failure rates, TSNB is assisted with several modalities including fluoroscopy, computed tomography, and ultrasonography. The present study describes our experience assessing the usefulness of thoracoscopy in TSNB for predicting compensatory hyperhidrosis before sympathectomy in primary hyperhidrosis. From September 2013 to October 2021, TSNB was performed under local anesthesia using a 2-mm thoracoscope in 302 patients with severe primary hyperhidrosis. Among the 302 patients, 294 were included for analysis. The target level of TSNB was T3 in almost all patients. The mean procedure time was 21 min. Following TSNB, the mean temperature of the left and right palms significantly changed from 31.5 to 35.3 °C and from 31.5 to 34.8 °C, respectively. With TSNB, primary hyperhidrosis was relieved in all patients. Pneumothorax occurred in six patients, in which no chest tube insertion was required. One patient developed hemothorax and was discharged the next day after small-bore catheter drainage. Transient ptosis developed in 10 patients and improved within a day in all patients. Our experiences showed that thoracoscopic TSNB is accurate, safe, and feasible to block the thoracic sympathetic nerve in patients with severe primary hyperhidrosis.

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