High-temperature X-ray analysis of phase evolution in Sr-doped zinc-silicate glasses

Looney, Mark G.; O’Shea, Helen; Redington, Wynette; Kelly, Gerard; Boyd, Daniel

doi:10.1016/j.jnoncrysol.2010.11.118

Cited by 8 publications

(19 citation statements)

References 41 publications

(65 reference statements)

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“…BT110 shows a profile where at 580 C approximately shrinkage begins. A previous study of these glass compositions by Looney et al 38 indicated that BT110 has a T g (glass transition temperature) close to this temperature at 600 C, which also corresponds well with the maximum rate of shrinkage occurring at 625 C. Following this initial shrinkage step, significant crystallization of the glass is known to occur, 38 subsequently the amount of shrinkage drops to 4% approximately up to 1000 C. It is noted that the presence of crystal structures can inhibit the sinterability of glass materials 39 and this may impact on subsequent densification. The densification of BT111 and BT112 appear to transpire at a consistent rate up to 940 C and 720 C approximately, respectively.…”

Section: Discussionmentioning

confidence: 93%

“…The mechanical strength of materials is directly influenced by their structure and the XRD revealed three fully crystalline GCs containing distinct crystalline phases. BT110 is shown to consist of three crystalline materials that occur at 1000 C, interestingly these phases are also present at T p1 , 38 indicating a very stable material structure over the temperature range. The crystalline phases identified comprise sodium zinc silicate (Na 2 ZnSiO 4 ) and strontium zinc silicate (Sr 2 ZnSi 2 O 7 ) phases shown to release therapeutic quantities of zinc and strontium, respectively, in simulated physiological conditions.…”

Section: Discussionmentioning

confidence: 94%

“…BT111 is noted to have a T p1 (first crystallization temperature) of 577, and a T g of 546 C, BT112 has a T g of 522 C and T p1 of 525 C, which may inhibit sintering, but also both contain a residual glass phase up to T P1 . 38 Investigation have not been carried out to indicate at what temperature the residual glass is converted to a crystalline structure, this transformation may explain some of the increase in densification observed, or may indicate that the amount of residual glass present was not large enough to become evident in the dilatometry study; however, these hypotheses cannot be confirmed with the results generated. It is noted that at T g no corresponding increase in densification occurs.…”

Section: Discussionmentioning

confidence: 94%

“…BT112 like BT111 consists of a three-phase system, where two of the crystal structures are also identifiable at T p1 . 38 Both calcium silicate (Ca 2 SiO 4 ) and sodium silicate (Na 2 SiO 3 ) found at T p1 and at 900 C have demonstrated biocompatibility. 40,42 The third crystalline structure is also a calcium silicate known as Wollastonite 2M or pseudo Wollastonite (CaSiO 3 ) whose biocompatibility is also well known.…”

Section: Discussionmentioning

confidence: 99%

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An evaluation of the processing conditions, structure, and properties (biaxial flexural strength and antibacterial efficacy) of sintered strontium–zinc–silicate glass ceramics

et al. 2011

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The use of artificial bone grafts has increased in order to satisfy a growing demand for bone replacement materials. Initial mechanical stability of synthetic bone grafts is very advantageous for certain clinical applications. Coupled with the advantage of mechanical strength, a material with inherent antibacterial properties would be very beneficial. A series of strontium-doped zinc silicate (Ca-Sr-Na-Zn-Si) glass ceramics have been characterized in terms of their crystalline structure, biaxial flexural strength and antibacterial efficacy based on the identification of optimum sintering conditions. All three glass ceramics, namely, BT110, BT111, and BT112 were found to be fully crystalline, with BT111 and BT112 comprising of biocompatible crystalline phases. The biaxial flexural strengths of the three glass ceramics ranged from 70 to 149 MPa and were shown to be superior to those of clinically established ceramics in dry conditions and following incubation in simulated physiological conditions. The bacteriostatic effect for each glass ceramic was also established, where BT112 showed an inhibitory effect against three of the most common bacteria found at implantation sites, namely, Enterococcus faecalis, methicillin-resistant Staphylococcus aureus (MRSA), and Pseudomonas aeruginosa. The results of the evaluation suggest that the materials studied offer advantages over current clinical materials and indicate the potential suitability of the glass ceramics as therapeutic bone grafts.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

An evaluation of the processing conditions, structure, and properties (biaxial flexural strength and antibacterial efficacy) of sintered strontium–zinc–silicate glass ceramics

et al. 2011

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“…7,29,35,39 The glass system mentioned has recently been studied in relation to phase transformations during thermal treatments up to the first crystallization temperature (T p1 ). 40 The study 40 enabled the authors to better understand the composition–structure relationships of the material during heat treatment, establishing the crystalline phases formed. This information provides a mechanism to control the bioactivity and mechanical properties of the strontium-doped zinc silicate glass ceramic.…”

Section: Introductionmentioning

confidence: 99%

Preliminary evaluation of therapeutic ion release from Sr-doped zinc-silicate glass ceramics

2011

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Bioactive and degradable porous bioceramics play an important role in many clinical situations. Porosity is essential to the performance of a material that is proposed to be used as an implantable osseous scaffold. Scaffolds provide a three dimensional support and template to osseous integration and vascularization. Combining the porosity of a scaffold with the ability of the scaffold material to deliver therapeutic ions to the site of implantation goes some way towards developing an ideal bone graft. A series of strontium-doped zinc silicate (Ca-Sr-Na-Zn-Si) glass ceramics scaffoldswere developed, whose porosity was measured to be between 93% and 96%, which is advantageous in terms of osseous integration and vascularization. The levels of Zn(2+) and Sr(2+) detected as a result of degradation of the crystalline phases were found to be 1.4-600 parts per million (ppm) and 0-583 ppm, respectively. The levels detected correlate well with the levels of Sr(2+) and Zn(2+)ions typically associated with clinical benefits, including antibacterial efficacy, osteoblastic differentiation and impaired osteoclastic resorption.

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Study of strontium-doped tricalcium silicate/hydroxyapatite composite cement prepared through sol–gel process

Thirumurugan

Lin

et al. 2022

J Aust Ceram Soc

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A composite cement made of strontium containing tricalcium silicate and hydroxyapatite (SrC3S/HAp) was prepared and studied through a two-stage sol–gel method. The elemental components are 75 wt% of strontium-doped tricalcium silicate (SrC3S) and 25 wt% of hydroxyapatite (HAp). According to previous studies, the SrC3S has good mechanical properties and hydraulic conductivity, and the HAp has good biocompatibility. Therefore, the 75SrC3S-25HAp powder with 10 wt% of NaH2PO4 solution was mixed to prepare the slurry material. This slurry was measured for the working time and setting time at 37 °C under saturated vapor pressure. The material properties were evaluated in terms of crystal structures, surface morphologies, and mechanical properties. The in vitro testing was conducted to determine the ion release rate and curing behavior under a simulated body fluid environment. Finally, the L929 murine fibroblast cells were cultured to study the biocompatibility of the material. The results indicated that the operating time was 15.2 min, and the setting time was 43.6 min. After being soaked into simulated body fluid for14 days of the experiment, the compressive strength of 75SrC3S-25HAp remained 22.1 MPa, and the release of calcium and strontium ions was 501.4 ppm and 49.5 ppm, respectively. The cell viabilities were higher than 70% in various concentrations. These results suggest the 75SrC3S-25HAp has excellent potential for bone cement application.

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High-temperature X-ray analysis of phase evolution in Sr-doped zinc-silicate glasses

Cited by 8 publications

References 41 publications

An evaluation of the processing conditions, structure, and properties (biaxial flexural strength and antibacterial efficacy) of sintered strontium–zinc–silicate glass ceramics

An evaluation of the processing conditions, structure, and properties (biaxial flexural strength and antibacterial efficacy) of sintered strontium–zinc–silicate glass ceramics

Preliminary evaluation of therapeutic ion release from Sr-doped zinc-silicate glass ceramics

Study of strontium-doped tricalcium silicate/hydroxyapatite composite cement prepared through sol–gel process

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