High-temperature hydroxyapatite-titanium interaction

Egorov, A. A.; Смірнов, В. В.; Shvorneva, L. I.; Kutsev, S. V.; Баринов, С. М.

doi:10.1134/s0020168510020147

Cited by 19 publications

(18 citation statements)

References 9 publications

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“…Furthermore, silver nanoparticles/HA biocomposites could be synthesized through γ-irradiation reduction of silver ions incorporated into HA particles [ 610 ]. At high temperatures, the presence of Ti metal phase was found to promote dehydration and decomposition of HA into β-TCP and TTCP [ 927 , 928 , 939 , 1011 ] and/or partial formation of β-TCP and calcium titanates instead of HA [ 603 , 930 , 942 , 1011 ]. Comparing with pure HA bioceramics manufactured under the same conditions, the HA/Ti biocomposites possessed a higher fracture toughness, bending strength, work of fracture, which is better suitable for the biomedical applications [ 936 ].…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

129

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The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

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Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

129

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“…With the increase of titanium dioxide, the undehydroxy HA reacted with titanium dioxide in the interface, and the reaction products were tricalcium phosphate (TCP) and calcium titanate (CaTiO 3 ) as shown in Equation (Balbinotti et al, ). Meanwhile, the generated oxygen would promote Equation to happen (Berezhnaya, Mittova, Kostyuchenko, & Mittova, ; Egorov, Smirnov, Shvorneva, Kutsev, & Barinov, ). With the temperature rising, HA may decompose into TCP and tetracalcium phosphate as described by Equation (Arifin et al, ; Yang et al, ; Ye, Liu, & Hong, ).…”

Section: Resultsmentioning

confidence: 99%

Direct 3‐D printing of Ti‐6Al‐4V/HA composite porous scaffolds for customized mechanical properties and biological functions

Zhou

et al. 2020

J Tissue Eng Regen Med

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Customized scaffold plays an important role in bone tissue regeneration. Precise control of the mechanical properties and biological functions of scaffolds still remains a challenge. In this study, metal and ceramic biomaterials are composited by direct 3‐D printing. Hydroxyapatite (HA) powders with diameter of about 25 μm and Ti‐6Al‐4V powders with diameter of 15–53 μm were mixed and modulated for preparing 3‐D printing inks formulation. Three different proportions of 8, 10, and 25 wt.% HA specimens were printed with same porosity of 72.1%. The green bodies of the printed porous scaffolds were sintered at 1,150°C in the atmosphere of argon furnace and conventional muffle furnace. The porosities of the final 3‐D‐printed specimens were 64.3 ± 0.8% after linear shrinkage of 6.5 ± 0.8%. The maximum compressive strength of the 3‐D‐printed scaffolds can be flexibly customized in a wide range. The maximum compressive strength of these scaffolds in this study ranged from 3.07 to 60.4 MPa, depending on their different preparation process. The phase composition analysis and microstructure characterization indicated that the Ti‐6Al‐4V and HA were uniformly composited in the scaffolds. The cytocompatibility and osteogenic properties were evaluated in vitro with rabbit bone marrow stromal cells (rBMSCs). Differentiation and proliferation of rBMSCs indicated good biocompatibility of the 3‐D‐printed scaffolds. The proposed 3‐D printing of Ti‐6Al‐4V/HA composite porous scaffolds with tunable mechanical and biological properties in this study is a promising candidate for bone tissue engineering.

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“…Figure 8 shows that the HA phase decomposed and transformed into tetracalcium phosphate (TTCP) and beta tricalcium phosphate (β-TCP). Egorov et al showed that the oxidation of titanium started at around 700 o C on composite titanium and HA was converted into TiO2 [42]. Figure 8 also shows that the sample (70 wt% Ti6Al4V : 30 wt% HA: PMMA) tended to exhibit a high level of oxidation, as demonstrated by the strong peak of TiO2 near 20 °C to 25 °C.…”

Section: X-ray Diffractionmentioning

confidence: 89%

“…Generally, the sintered component of HA/Ti is formed in the secondary phase [41][42][43][44]. Figures 8 to 10 show that the samples were converted into a new phase after sintering at 1200 o C. The amount of titanium in the mixture affected the peak intensity [45], and HA decomposed and transformed into a secondary-phase substance, such as tetracalcium phosphate and tricalcium phosphate [46].…”

Section: X-ray Diffractionmentioning

confidence: 99%

Porous titanium alloy/hydroxyapatite composite using powder compaction route

Arifin¹,

Sulong²,

Fun³

et al. 2017

J. MECH. ENG. SCI.

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Titanium alloys (Ti6Al4V) and hydroxyapatite (HA) are widely used as implant materials. Ti6Al4V has good mechanical properties and corrosion resistance, whereas HA has excellent biocompatibility but its mechanical properties are weak. The combination of properties between Ti6Al4V and HA is expected to produce a superior material for bio-implants. The aim of this work is to analyse the fabricating porous Ti6Al4V/HA composite through powder compaction with the application of two types of space holders. Sodium chloride (NaCl) and polymethyl methacrylate (PMMA) were selected as the space holder agents. Space holders were removed by solvent debinding (NaCl) and thermal debinding (PMMA). Sintering was performed in a furnace at 1200 °C for 1.5 h. The Archimedes method was carried out to obtain the porosity of the sintered body. Samples where NaCl was used exhibited higher porosity than the samples where for PMMA was used. The high porosity achieved among the successfully sintered samples was 43.9%. Interconnected porous was clearly observed on the sintered composites with a successfully generated size range of 2 μm to 25 μm.

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High-temperature hydroxyapatite-titanium interaction

Cited by 19 publications

References 9 publications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Direct 3‐D printing of Ti‐6Al‐4V/HA composite porous scaffolds for customized mechanical properties and biological functions

Porous titanium alloy/hydroxyapatite composite using powder compaction route

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