High Success Rate of Parathyroid Reoperation may be Achieved with Improved Localization Diagnosis

Hessman, Ola; Stålberg, Peter; Sundín, Anders; Garske, Ulrike; Rudberg, Claes; Eriksson, Lars-Gunnar; Hellman, Per; Åkerström, Göran

doi:10.1007/s00268-008-9537-5

Cited by 114 publications

(87 citation statements)

References 37 publications

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“…According to Hessman et al, the success rate of parathyroidectomy is greater than 95%, with low complication rates in cases performed by experienced surgeons (21). The results of the present study are similar to those of Hessman et al (21).…”

Section: Discussionsupporting

confidence: 90%

Surgical treatment of primary hyperparathyroidism due to parathyroid tumor: A 15-year experience

Zhang

Liu

2016

Oncology Letters

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Abstract. The aim of this study was to highlight our experience over a 15-year period in dealing with primary hyperparathyroidism (PHPT) due to a parathyroid tumor. Parathyroidectomy is the standard therapy for patients with PHPT. Our study included all patients with PHPT treated by parathyroidectomy at the Affiliated Cancer Hospital of Zhengzhou University, China. Between 1998 and 2013, a total of 107 patients were recruited. Their clinical data, presentation, laboratory examinations, imageological diagnoses and surgical approaches were analyzed retrospectively. Eighty-four cases (78.5%) were followed up. During a median follow-up period of 5.7 years, a total of 80 patients were without recurrence and metastasis. The main symptoms of PHPT patients were palpable neck mass, joint pains and pathological fracture. The high levels of preoperative parathyroid hormone (PTH) and serum calcium in PHPT patients decreased to below the normal upper limit within 3 days of surgery. The sensitivity of neck ultrasonography, sestamibi scanning, CT, MRI and the combination of three or four types of test were 86.0%, 90.4%, 80.8%, 79.6% and 96.1%, respectively. A 50% or greater drop in PTH levels within 20 min compared with the highest PTH levels before surgery occurred in 95/107 cases (88.8%). Transient hypocalcemia was the most common surgical complication. The ultra sonography and sestamibi scan is the most effective examination for parathyroid tumor. The 20 min PTH measurement appears to be extremely useful, and avoids unnecessary bilateral exploration.

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Section: Discussionsupporting

confidence: 90%

Surgical treatment of primary hyperparathyroidism due to parathyroid tumor: A 15-year experience

Zhang

Liu

2016

Oncology Letters

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“…The non-invasive techniques used for this include ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), sestamibi scintigraphy (MIBI), and methionine-PET). Before reoperation, the sensitivity of US, CT, MRI, MIBI, and methionine-PET has been reported at 20-80 % (7-11), 40-90 % (9,11,12), 65-80 % (8,11,12), 50-90 % (8,9,(11)(12)(13), and about 80% (14), respectively.…”

Section: Introductionmentioning

confidence: 99%

Super-selective venous sampling in conjunction with quickPTH for patients with persistent primary hyperparathyroidism: report of five cases

Gimm

Arnesson²,

Olofsson³

et al. 2012

Surg Today

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“…It must be stressed that if a reoperation is necessary in patients with persistent primary hyperparathyroidism, the most sensitive examination (50-88%) among non-invasive types will be magnetic resonance (MR) [49,50].…”

Section: Szkolenie Podyplomowementioning

confidence: 99%

Imaging diagnostics for primary hyperparathyroidism

Gawrychowski¹,

Buła²

2013

Endokrynologia Polska

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Primary hyperparathyroidism (PHP) is a benign condition characterised by malignant potential. Even in specialist wards, 5-10% of operations for PHP are unsuccessful. The main reasons seem to be ectopy of the parathyroid gland, numerous adenomas, multiglandular parathyroid hyperplasia, and intrathyroid location of the parathyroid. The last three decades have witnessed a rapid progression in imaging diagnostics.

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High Success Rate of Parathyroid Reoperation may be Achieved with Improved Localization Diagnosis

Abstract: Reoperative parathyroid surgery is challenging. Results can be improved by consistently applied sensitive methods of preoperative imaging, and reoperative procedures may then achieve nearly the same success rates as primary operations.

Cited by 114 publications

References 37 publications

Surgical treatment of primary hyperparathyroidism due to parathyroid tumor: A 15-year experience

Surgical treatment of primary hyperparathyroidism due to parathyroid tumor: A 15-year experience

Super-selective venous sampling in conjunction with quickPTH for patients with persistent primary hyperparathyroidism: report of five cases

Imaging diagnostics for primary hyperparathyroidism

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