High stretch cycling inhibits the morphological and biological decidual process in human endometrial stromal cells

Saito, Ryoichi; Kajihara, Takeshi; Takamura, Masashi; Tochigi, Hideno; Sato, Tsuyoshi; Ishihara, Osamu

doi:10.1002/rmb2.12341

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…During infertility treatment, clinicians often assess the endometrium by transvaginal ultrasound and transabdominal ultrasound to evaluate endometrial receptivity. Assessing endometrial receptivity by ultrasound involves measuring various parameters, including endometrial thickness (EMT) [ 5 ], endometrial volume [ 6 ], endometrial pattern [ 7 ], and endometrial wave-like activity [ 8 ]. Most previous studies have focused on EMT and have revealed an association between an EMT of <7 mm and poor pregnancy outcomes [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Endometrial compaction is associated with the outcome of artificial frozen-thawed embryo transfer cycles: a retrospective cohort study

Wei

et al. 2023

J Assist Reprod Genet

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Introduction The relationships between the outcome of frozen-thaw embryo transfer (FET) cycle and endometrial compaction were not quite consistent. Objective To analyze the relationship between the outcome of FET cycle and endometrial compaction. Materials and methods A total of 1420 women using FET were researched. The change in endometrial thickness on ET day and those on the day of progesterone (P) administration start is the basis for grouping. Group 1 was endometrial compaction group, and group 2 was the endometrial non-compaction group. Outcome measure was clinical pregnancy, estradiol (E2) levels, progesterone (P) levels, endometrial morphology, and thickness in each period of FET cycle. Results A significantly lower clinical pregnancy rate was observed in group 2 in comparison with group 1 (43.4% vs. 55.1%, P < 0.01). In addition, P levels on the day of P administration start were lower in group 2 (0.73 ± 0.93 ng/ml vs. 0.90 ± 1.85 ng/ml, P = 0.006), while E2 levels on ET day were higher in group 2 (316.42 ± 304.95 pg/ml vs. 257.88 ± 219.15 pg/ml, P = 0.001) than in group 1. The binary logistic regression analysis showed a lower rate of clinical pregnancy in group 2 (aOR = 0.617, 95% CI 0.488-0.779, P = 0.001). Conclusions Clinical pregnancy rates were significantly higher in women with endometrial compaction on ET day compared to women with no changes or thickening. Therefore, we recommend paying closer attention to endometrial compaction in women undergoing FET as a method to estimate endometrial receptivity.

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Section: Introductionmentioning

confidence: 99%

Endometrial compaction is associated with the outcome of artificial frozen-thawed embryo transfer cycles: a retrospective cohort study

Wei

et al. 2023

J Assist Reprod Genet

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Nuclear actin assembly is an integral part of decidualization in human endometrial stromal cells

Tamura,

Miyamoto,

Hatanaka

et al. 2024

Commun Biol

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Decidualization of the human endometrium is critical for establishing pregnancy and is entailed by differentiation of endometrial stromal cells (ESCs) into decidual cells. During decidualization, the actin cytoskeleton is dynamically reorganized for the ESCs’ morphological and functional changes. Although actin dynamically alters its polymerized state upon external stimuli not only in the cytoplasm, but also in the nucleus, nuclear actin dynamics during decidualization have not been elucidated. Here, we show that nuclear actin was specifically assembled during decidualization of human ESCs. This decidualization-specific formation of nuclear actin filaments was disassembled following the withdrawal of the decidualization stimulus, suggesting its reversible process. Mechanistically, RNA-seq analyses revealed that the forced disassembly of nuclear actin resulted in the suppression of decidualization, accompanied with the abnormal upregulation of cell proliferation genes, leading to incomplete cell cycle arrest. CCAAT/enhancer-binding protein beta (C/EBPβ), an important regulator for decidualization, was responsible for downregulation of the nuclear actin exporter, thus accelerating nuclear actin accumulation and its assembly for decidualization. Taken together, we demonstrate that decidualization-specific nuclear actin assembly induces cell cycle arrest for establishing the decidualized state of ESCs. We propose that not only the cytoplasmic actin, but also nuclear actin dynamics profoundly affect decidualization process in humans for ensuring pregnancy.

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High stretch cycling inhibits the morphological and biological decidual process in human endometrial stromal cells

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 29 publications

Endometrial compaction is associated with the outcome of artificial frozen-thawed embryo transfer cycles: a retrospective cohort study

Endometrial compaction is associated with the outcome of artificial frozen-thawed embryo transfer cycles: a retrospective cohort study

Nuclear actin assembly is an integral part of decidualization in human endometrial stromal cells

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