High-strength resorbable brushite bone cement with controlled drug-releasing capabilities

Hofmann, Michael; Mohammed, Afzal-Ur-Rahman; Perrie, Yvonne; Gbureck, Uwe; Barralet, Jake E.

doi:10.1016/j.actbio.2008.08.005

Cited by 135 publications

(128 citation statements)

References 31 publications

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“…Both cast and injected cement cylinders were left to set in the mould for 1 h in an incubator at 37 °C, demoulded, and stored in an incubator at 37 °C until use. Injected cement cylinders were manufactured so as to simulate the intended clinical delivery method and this was compared with cast versions (n = 10) as this is the typical process used in the literature [29] and [30].…”

Section: 2mentioning

confidence: 99%

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cox

Jamshidi

Eisenstein

et al. 2016

Materials Science and Engineering: C

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Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calciumphosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p=0.01) improved the compressive strength (5.8± 0.7 MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6 hour period (b28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16 μg/mL) and Staphylococcus epidermidis (1 μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections.

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Section: 2mentioning

confidence: 99%

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cox

Jamshidi

Eisenstein

et al. 2016

Materials Science and Engineering: C

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“…Espanol et al (2009) showed that a decrease in medium particle size of the powder reactants did not influence the total porosity of a calcium deficient apatite, although the pore size distribution was affected [5]. It was found by Hofmann et al (2009) that the particle size distribution of the powder reactants affects the porosity of brushite cement, generally using mainly smaller particles resulted in a lower porosity [3]. Conversely, found that a -3 -larger average particle size of monocalcium phosphate monohydrate in combination with β-tricalcium phosphate generally generated a smaller porosity in a brushite cement [7].…”

Section: Introductionmentioning

confidence: 58%

“…mixing and moulding) other factors, such as particle size distribution of the cement powder, have been found to influence the porosity [3,5,7]. To simplify the model both these factors were omitted.…”

Section: Discussionmentioning

confidence: 99%

“…It has been found that an increase in liquid-to-powder (L/P) ratio increases the porosity of both apatite and brushite cements [3,[5][6][7]. Espanol et al (2009) showed that a decrease in medium particle size of the powder reactants did not influence the total porosity of a calcium deficient apatite, although the pore size distribution was affected [5].…”

Section: Introductionmentioning

confidence: 99%

“…However, an increased porosity has a negative effect on the mechanical properties [2], e.g. hardness, compressive strength and diametrial tensile strength [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Porosity prediction of calcium phosphate cements based on chemical composition

Öhman

Unosson

Carlsson

et al. 2015

J Mater Sci: Mater Med

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The porosity of calcium phosphate cements has an impact on several important parameters, such as strength, resorbability and bioactivity.A model to predict porosity for biomedical cements would be a useful tool. At the moment such a model only exists for Portland cements. The aim of this study was to develop and validate a first porosity prediction model for calcium phosphate cements.On the basis of chemical reaction, molar weight and density of components, a volume-based model was developed and validated using calcium phosphate cement as model material.60m% β-TCP and 40m% MCPM were mixed with deionized water, at different liquid-topowder ratios. Samples were set for 24h at 37°C and 100% relative humidity. Thereafter, samples were dried either under vacuum at room temperature for 24h or in air at 37°C for 7 days. Porosity and phase composition were determined.It was found that the two drying protocols led to the formation of brushite and monetite, respectively. The model was found to predict well the experimental values and also data reported in the literature for apatite cements, as deduced from the small absolute average residual errors (<2.0%).In conclusion, a theoretical model for porosity prediction was developed and validated for brushite, monetite and apatite cements. The model gives a good estimate of the final porosity and has the potential to be used as a porosity prediction tool in the biomedical cement field.

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Ceramics for Drug Delivery

Manzano

2014

Bio‐Ceramics With Clinical Applications

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High-strength resorbable brushite bone cement with controlled drug-releasing capabilities

Cited by 135 publications

References 31 publications

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Porosity prediction of calcium phosphate cements based on chemical composition

Ceramics for Drug Delivery

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