High speed spectral domain polarization sensitive optical coherence tomography of the human retina

Götzinger, Erich; Pircher, Michael; Hitzenberger, Christoph K.

doi:10.1364/opex.13.010217

Cited by 204 publications

(157 citation statements)

References 37 publications

(71 reference statements)

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“…PS-OCT can avoid these problems. Retardation and birefringence measurement and imaging of the RNFL were among the first applications of PS-OCT in the eye [65, [103][104][105][106][107][108][109]. Figure 13 shows an example of PS-OCT retardation imaging in the optic nerve head (ONH) region.…”

Section: Imaging and Quantification Of The Retinal Nerve Fiber Layermentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

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Abstract:Optical coherence tomography (OCT) is now a well-established modality for highresolution cross-sectional and three-dimensional imaging of transparent and translucent samples and tissues. Conventional, intensity based OCT, however, does not provide a tissuespecific contrast, causing an ambiguity with image interpretation in several cases. Polarization sensitive (PS) OCT draws advantage from the fact that several materials and tissues can change the light's polarization state, adding an additional contrast channel and providing quantitative information. In this paper, we review basic and advanced methods of PS-OCT and demonstrate its use in selected biomedical applications. Drexler, and J. G. Fujimoto, eds. (Springer, Cham, 2015), pp. 1137-1162. 6. J. F. de Boer and T. E. Milner, "Review of polarization sensitive optical coherence tomography and Stokes vector determination," J. Biomed. Opt. 7(3), 359-371 (2002). 7. M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Polarization Sensitive Optical Coherence Tomography in the Human Eye," Prog. Retin. Eye Res. 30(6), 431-451 (2011). 8. D. Stifter, "Beyond biomedicine: a review of alternative applications and developments for optical coherence tomography," Appl. Phys. B 88(3), 337-357 (2007). 9. R. C. Jones, "A new calculus for the treatment of optical systems I. Description and discussion of the calculus," J. Opt. Soc. Am. A 31(7), 488-493 (1941). 10. J. J. Gil and E. Bernabeu, "Obtainment of the polarizing and retardation parameters of a non-depolarizing optical system from the polar decomposition of its Mueller matrix," Optik (Stuttg.) 76, 67-71 (1987). 11. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley Interscience, New York, NY, 1983). 12. W. A. Shurcliff and S. S. Ballard, Polarized Light (Van Nostrand, New York, 1964). 13. B. H. Park, C. Saxer, S. M. Srinivas, J. S. Nelson, and J. F. de Boer, "In vivo burn depth determination by highspeed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6(4), 474-479 (2001). 14. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11(7), 782-793 (2003). 15. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, "High-speed fiber based polarizationsensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25(18), 1355-1357 (2000). Rylander, "Polarization sensitive optical coherence tomography of the rabbit eye," IEEE J. Sel. Top. Quantum Electron. 5(4), 1159-1167 (1999 Schmidt-Erfurth, and S. Sacu, "Retinal pigment epithelial features in central serous chorioretinopathy identified by polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 57(4), 1595-1603 (2016). 131. C. Schütze, C. Ahlers, M. Pircher, B. Baumann, E. Götzinger, F. Prager, G. Matt, S. Sacu, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Morphologic characteristics of idiopathic juxtafoveal telangiectasia using spectraldomain and po...

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Section: Imaging and Quantification Of The Retinal Nerve Fiber Layermentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

Self Cite

349

241

View full text Add to dashboard Cite

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“…For each image, the spectra with different phase shift (0, π /2, π , 3π /2) were assorted to their own groups. The averaged spectrum for each phase shift is calculated and subtracted from the original spectra with corresponding phase shift [30,31]. Using that procedure the great fixed-pattern noise rejection in the final OCT image is obtained.…”

Section: Setup and Data Processingmentioning

confidence: 99%

Complex Conjugate Resolved Retinal Imaging by One-micrometer Spectral Domain Optical Coherence Tomography Using an Electro-optical Phase Modulator

Fabritius

Makita

Yamanari

et al. 2011

Journal of the Optical Society of Korea

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Full-range spectral domain optical coherence tomography (SD-OCT) with a 1-µm band light source is shown here. The phase of the reference beam is continuously stepped while the probing beam scans the sample laterally (B-scan). The two dimensional spectral interferogram obtained is processed by a Fourier transform method to obtain a complex spectrum leading to a full-range OCT image. A detailed mathematical explanation of the complex conjugate resolving method utilized is provided. The system's measurement speed was 7.96 kHz, the measured axial resolution was 9.6 µm in air and the maximum sensitivity 99.4 dB. To demonstrate the effect of mirror image elimination, In vivo human eye pathology was measured.

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“…While conventional OCT detects the reflectivity of scattering layers, the measurement of polarization dependent effects in tissue, like birefringence and depolarization, requires an extended setup [1]. Several concepts have proved capability, but most common PS-OCT systems are characterized by a high complexity due to numerous additional components for polarization adjustment, maintenance and detection [2,3]. Since fast tunable lasers [4] are available, the temporally resolved detection of interference spectra for frequency domain imaging has become the preferred choice for high speed OCT concepts.…”

Section: Introductionmentioning

confidence: 99%

Polarization sensitive optical coherence tomography utilizing a buffered swept source laser

Golde

Kirsten

Koch

2017

Current Directions in Biomedical Engineering

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Abstract:We present an approach for polarization sensitive optical coherence tomography (PS-OCT) that solely requires a modification of the light source, a buffered swept source laser. For this purpose a single-mode fiber-based Fourier domain mode locked laser is extended by fourfold buffering with manual fiber polarization controllers to emit alternating sweep polarizations, while the polarization contrast calibration is realized by a high-speed polarimeter. As the introduced setup utilizes standard scanning and detection units, the proposed method is a promising way to enhance various swept source OCT systems by polarization sensitive imaging. Preliminary measurements of a human finger nail with different polarization contrasts demonstrate the feasibility of the concept.

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High speed spectral domain polarization sensitive optical coherence tomography of the human retina

Cited by 204 publications

References 37 publications

Polarization sensitive optical coherence tomography – a review [Invited]

Polarization sensitive optical coherence tomography – a review [Invited]

Complex Conjugate Resolved Retinal Imaging by One-micrometer Spectral Domain Optical Coherence Tomography Using an Electro-optical Phase Modulator

Polarization sensitive optical coherence tomography utilizing a buffered swept source laser

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