High-Speed Electroseparations Inside Silica Colloidal Crystals

Zheng, Suping; Ross, Eric E.; Legg, Michael A.; Wirth, Mary J.

doi:10.1021/ja062676l

Cited by 65 publications

(73 citation statements)

References 15 publications

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“…Slabs of silica colloidal crystals have been used for separations of small molecules and for DNA and protein sieving [155,156]. The plate heights were well above 1 μm yet these should achieve sub-micrometer plate heights by virtue of the crystalline packing [155,156].…”

Section: Future Perspectives For Column Technologymentioning

confidence: 99%

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Fekete¹,

Perrenoud²,

Guillarme

2014

CCHG

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Abstract:The current trend in high performance liquid chromatography (HPLC) tends toward the achievement of higher separation efficiency and shorter analysis time. Indeed, better performance in LC has become increasingly important in recent years mainly driven by the challenges of either analyzing more complex samples or increasing the numbers of samples per time unit. In the recent development of particle technology, the use of fully porous sub-2 m particles and sub-3 m shell particles have received considerable attention. Beside packed columns, the new generation of silica-based monolithic columns also offers very high separation power. However, to take full advantage of these innovative phases, the chromatographic system has also to be drastically optimized in terms of upper pressure limit and system volume.This revolution in column technology now spreads and covers several modes of liquid chromatography such as reversedphase liquid chromatography (RPLC), hydrophilic interaction liquid chromatography (HILIC), or even supercritical fluid chromatography (SFC). The HILIC and SFC, which can be considered as alternative modes of chromatography, could also be useful to extend the applicability of chromatography towards the analysis of very hydrophilic and lipophilic compounds, respectively.The present review gives an insight about the theory behind the success of current column technology and presents a summary of latest applications, using various modes of one-dimensional chromatography (RPLC, HILIC, SFC). This paper also shows that theoretically expected column efficiency could sometimes be compromised in practical work especially in the case of narrow bore columns.

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Section: Future Perspectives For Column Technologymentioning

confidence: 99%

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Fekete¹,

Perrenoud²,

Guillarme

2014

CCHG

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“…The flexibility of DLW to vary microfluidic channel widths and PC properties were essential to tune the PC structure for enabling such analyte acceleration and will be attractive for further optimization of electrophoretic mobility and flow rate for demonstrating multi-analyte separation. While such separation was previously demonstrated with colloidal crystals [15,56], the novel flexibility inherent to DLW for tuning the PC structure will offer significant advantages for further advances in 3D PC-based CEC development. The DLW approach promises to create LOACs with multiple and more compact functionalities on a single chip that are flexible in (1) tuning a PC's Γ-Z periodicity, (2) positioning the WGs for probing PC stopbands and microfluidic channels, (3) dynamic tuning of CEC performance, and (4) carving out microfluidic channels and reservoirs into compact 3D networks.…”

Section: Significance and Future Workmentioning

confidence: 99%

“…The development of simultaneous chromatographic and spectroscopic analysis in PCembedded microchannels can be extended beyond colloidal columns [15,56] and laser patterned photoresist to harness the high resolution of DLW and chemical etching directly in fused silica to form all-silica templates of 3D-PC structure [57] together with probing optical WGs. Such devices may support the higher pressures required for HPLC or be further extended to integrating laser-formed WGs with microfluidic channels that may replace photonic crystal fibers used previously for optical chromatography demonstrations [58].…”

Section: Significance and Future Workmentioning

confidence: 99%

Laser-written photonic crystal optofluidics for electrochromatography and spectroscopy on a chip

Haque

Zacharia

et al. 2013

Biomed. Opt. Express

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Femtosecond laser processes were optimized for nonlinear interactions with various optical materials to develop a novel biophotonic lab-on-a-chip device that integrates laser-formed waveguides (WGs), microfluidic channels and photonic crystals (PCs). Such integration seeks the unique demonstration of dual PC functionalities: (1) efficient chromatographic separation and filtration of analytes through a porous PC embedded inside a microfluidic channel and (2) optofluidic spectroscopy through embedded WGs that probe PC stopband shifts as varying analyte concentrations flow and separate. The building blocks together with their integration were demonstrated, providing embedded porous PCs through which electrochromatography drove an accelerated mobile phase of analyte and an optical stopband was probed via integrated buried WGs. Together, these laboratory results underpin the promise of simultaneous chromatographic and spectroscopic capabilities in a single PC optofluidic device. ©2013 Optical Society of America References and links1. D. Psaltis, S. R. Quake, and C. Yang, "Developing optofluidic technology through the fusion of microfluidics and optics," Nature 442(7101), 381-386 (2006). 2. C. Monat, P. Domachuk, and B. J. Eggleton, "Integrated optofluidics: A new river of light," Nat. Photonics 1(2), 106-114 (2007). 3. P. S. Nunes, N. A. Mortensen, J. P. Kutter, and K. B. Mogensen, "Photonic crystal resonator integrated in a microfluidic system," Opt. Lett. 33(14), 1623-1625 (2008). 4. V. Maselli, J. R. Grenier, S. Ho, and P. R. Herman, "Femtosecond laser written optofluidic sensor: Bragg grating waveguide evanescent probing of microfluidic channel," Opt. Express 17(14), 11719-11729 (2009 1729-1731 (1996). 17. R. Osellame, H. J. W. M. Hoekstra, G. Cerullo, and M. Pollnau, "Femtosecond laser microstructuring: an enabling tool for optofluidic lab-on-chips," Laser Photon. Rev. 5(3), 442-463 (2011). 18. J. Bhawalkar, G. He, and P. Prasad, "Nonlinear multiphoton processes in organic and polymeric materials," Rep.Prog. Phys. 59(9), 1041-1070 (1996).

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“…In Wirth's group [37], a 20 mm thick colloidal crystal of silica particles was obtained by evaporation and subsequent selfassembly of 200 nm calcinated silica colloids. After C 20 functionalization, the phase was used for the electrochromatographic RP separation of three dyes having similar electrophoretic mobilities.…”

Section: Packed Particlesmentioning

confidence: 99%

Liquid chromatography on chip

Faure

2010

Electrophoresis

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LC is one of the most powerful separation techniques as illustrated by its leading role in analytical sciences through both academic and industrial communities. Its implementation in microsystems appears to be crucial in the development of mu-Total Analysis System. If electrophoretic techniques have been widely used in miniaturized devices, LC has faced multiple challenges in the downsizing process. During the past 5 years, significant breakthroughs have been achieved in this research area, in both conception and use of LC on chip. This review emphasizes the development of novel stationary phases and their implementation in microchannels. Recent instrumental advances are also presented, highlighting the various driving forces (pressure, electrical field) that have been selected and their respective ranges of applications.

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High-Speed Electroseparations Inside Silica Colloidal Crystals

Cited by 65 publications

References 15 publications

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Laser-written photonic crystal optofluidics for electrochromatography and spectroscopy on a chip

Liquid chromatography on chip

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