High specific activity tritium labelling of some sigma-1 receptor agonists

Tritium NMR: A compilation of data and a practical guide

“…Ahern et al [49] reported the tritiation of the serotonin receptor agonists buspirone shown in Figure 28, which…”

“…Ahern et al [ 49 ] reported the tritiation of the serotonin receptor agonists buspirone shown in Figure 28, which possesses a rather unique azaspiro[4,5]decane‐7,9‐dione structural moiety. This spectrum documents the exclusive tritium labeling of the product in the central methylene groups of the alkyl chain.…”

“…Ahern et al [ 65 ] performed a high specific activity tritium labeling of some sigma‐1receptor agonists, which are known to be an inter‐organelle signaling modulators and participants in the cellular stress protection. In that paper, a high specific activity tritiation and characterization of an important sigma‐1 receptor, the agonist (+)‐SKF‐10,047, was found.…”

“…Tritium NMR spectrum of ditritiated derivative of buspirone, recorded in CDCl 3 at 320 MHz. Reproduced with minor editing privilege from Ahern et al [49] with the permission of Springer Nature F I G U R E 2 9 Tritium NMR spectrum of trefentanil, recorded in CD 3 OD at 320 MHz. Reproduced with minor editing privilege from Ahern et al [50] with the permission of Elsevier these substances have been of particular importance in biology.…”

“…Reproduced with minor editing privilege from Andrews et al [64] with the permission of Elsevier F I G U R E 4 3 Tritium proton decoupled NMR spectrum of the agonist (+)-SKF-10,047 recorded in CD 3 OD at 320 MHz. Reproduced with minor editing privilege from Ahern et al [65] with the permission of Springer Nature members of this family including [ 3 H] dihydrocapsaicin and [N-methyl-3 H] atropine, which are shown accordingly, on top and bottom of Figure 51.…”