High Sodium Intake Strengthens the Association of ACE I/D Polymorphism with Blood Pressure in a Community

Abstract

A high sodium intake strengthens the association of ACE I/D polymorphism with BP levels in community-based samples.

Physician–Pharmacist Cooperation Program for Blood Pressure Control in Patients With Hypertension: A Randomized-Controlled Trial

“…Age-and sexadjusted mean 24-h sodium excretion values across quintiles of the baseline sodium reduction score (n = 1,674) were 203, 195, 183, 180, 168 mmol/day (P for trend <0.0001). 16 Data relating to 24-h sodium excretion values are not reported for this study because of the limited sample size (84/132 patients, 64%). All laboratory assays, blinded as to identification of the patient, were analyzed at Kotobiken Medical Laboratories (Tsukuba, Japan), using standard methods.…”

“…This scoring system has been validated previously. 11,16 The correlation between sodium reduction score and sodium excretion has also been determined previously. Age-and sexadjusted mean 24-h sodium excretion values across quintiles of the baseline sodium reduction score (n = 1,674) were 203, 195, 183, 180, 168 mmol/day (P for trend <0.0001).…”

“…Adherence to medication regimens at the baseline and 6-month follow-up time points were not significantly different between the intervention and control groups: median (interquartile range), 100 (93-100) % vs. 100 (94-100) % at baseline, P = 0.90; and 100 (97-100) % vs. 100 (93-100) % at 6-month follow-up, P = 0.17. The total time spent per patient on physician consultation, including the physician-pharmacist interaction time, was also not significantly different between the intervention and control groups: median (interquartile range), 17(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) vs. 17 (13-23) min, P = 0.55.changes in antihypertensive medication regimensDuring the intervention period, 20 of 64 patients (31%) in the intervention group discontinued antihypertensive medications or decreased the dosage of these medications as compared to only 5 of 64 patients (8%) in the control group (P < 0.0001).…”

Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head

“…VEGFC is another essential factor for angiogenesis and endothelial cell growth, and participates in the progression and development of angiogenic diseases (Cao et al, 1998). Angiotensin I converting enzyme (ACE) plays a key role in the rennin-angiotensin system and has been associated with various diseases, including coronary artery disease, type 2 diabetes, hypertension, stroke, and lupus (Saeed et al, 2005;Tsai et al, 2007;Yamagishi et al, 2007). In addition, ACE has been identified as a representative candidate gene in cardiovascular diseases .…”

Effects of two training protocols on Angiotensin I-converting enzyme (ACE) activity in horses

“…2006; Leeb et al . 2006; Yamagishi et al . 2007), although no information was available for horses until recently (Costa et al .…”