High Signal Intensity on Diffusion-Weighted Images Reflects Acute Phase of Deep Vein Thrombus

Gi, Toshihiro; Kuroiwa, Yasuyoshi; Yamashita, Atsushi; Mizutani, Yuko; Asanuma, Taketoshi; Miyati, Tosiaki; Maekawa, Kazunari; Aman, Murasaki; Imamura, Takuroh; Asada, Yujiro

doi:10.1055/s-0040-1714280

Cited by 10 publications

(14 citation statements)

References 29 publications

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“…(92%) as compared to 85% by Grey scale. This finding of present study coincides with that of Gi T et.al (2020) 14. Similarly, it is supported also by SteveGoodacre et.al.…”

supporting

confidence: 94%

Comparison of gray scale versus Doppler ultrasound to detect deep venous thrombosis in lower extremities.

Tauqir¹,

Tazeen

Khadija

et al. 2021

TPMJ

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Objectives: The objective was to determine the accuracy of Gray Scale versus Doppler Ultrasound to Detect Deep Venous Thrombosis in Lower Extremities. Study Design: Cross Sectional Analytical study. Setting: The University of Lahore and Shalimar Hospital Lahore. Period: May to October 2020. Material & Methods: After a permission from the ethical committee and a written consent of the patients, on the basis of the clinical suspicions of deep vein thrombosis, A total of 140 patients of both the genders, aging from 20 to 90 years, were referred for Gray Scale & Doppler ultrasound examination. The convenient sampling technique and Statistical software for social sciences (SPSS version 22.0) were used for the analysis of data. Results: In 140 patients’ present study on Gray Scale ultrasound, 120 (85%) cases were observed with significantly increased blood vessel size, intraluminal echogenicity and a loss of compressibility However, on Doppler ultrasound, 130 (92%) cases were detected possessing significantly increased blood vessel size, intraluminal echogenicity, absence of blood flow and negative augmentation effect. Conclusions: From the result of present study, it is concluded that Doppler may be used as gold standard to diagnose the DVT in the lower extremities. This study concludes also that DVT detection accuracy difference between Doppler and Gray Scale ultrasound is minor i.e. 1:1.08. This minor difference encourages the radiology practitioners of periphery to screen DVT in lower extremities through Gray Scale ultrasound, if Doppler ultrasound is unavailable there.

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“…(92%) as compared to 85% by Grey scale. This finding of present study coincides with that of Gi T et.al (2020) 14. Similarly, it is supported also by SteveGoodacre et.al.…”

supporting

confidence: 94%

Comparison of gray scale versus Doppler ultrasound to detect deep venous thrombosis in lower extremities.

Tauqir¹,

Tazeen

Khadija

et al. 2021

TPMJ

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“…thrombus age in patients with deep venous thrombosis 30 . A rabbit model of jugular venous thrombus has also indicated that the number of macrophages in the thrombus increases in the thrombus over time 31 . However, it is important to note that CD 163positive cell density increases during the first few days after thrombosis formation and then decreases slowly 32 .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…30 A rabbit model of jugular venous thrombus has also indicated that the number of macrophages in the thrombus increases over time. 31 However, it is important to note that CD 163-positive cell density increases during the first few days after thrombosis formation and then decreases slowly. 32 Therefore, we divided the thrombi according to tertiles of CD163-positive cell density based on the assumption that thrombi in the lowest tertile were younger than those in the middle and highest tertiles.…”

Section: Thrombus Agementioning

confidence: 99%

An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke

et al. 2021

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Background: Thrombosis is a dynamic process, and a thrombus undergoes physical and biochemical changes that may alter its response to reperfusion therapy. This study assessed whether thrombus age influenced reperfusion quality and outcomes after mechanical thrombectomy for cerebral embolism. Methods: We retrospectively evaluated 185 stroke patients and thrombi that were collected during mechanical thrombectomy at three stroke centers. Thrombi were pathologically classified as fresh or older based on their granulocytes’ nuclear morphology and organization. Thrombus components were quantified, and the extent of NETosis (the process of neutrophil extracellular trap formation) was assessed using the density of citrullinated histone H3-positive cells. Baseline patient characteristics, thrombus features, endovascular procedures, and functional outcomes were compared according to thrombus age. Results: Fresh thrombi were acquired from 43 patients, and older thrombi were acquired from 142 patients. Older thrombi had a lower erythrocyte content (P<0.001) and higher extent of NETosis (P=0.006). Restricted mean survival time analysis revealed that older thrombi were associated with longer puncture-to-reperfusion times (difference: 15.6 minutes longer for older thrombi, P=0.002). This association remained significant even after adjustment for erythrocyte content and the extent of NETosis (adjusted difference: 10.8 min, 95% CI: 0.6–21.1 min, P=0.039). Compared with fresh thrombi, older thrombi required more device passes before reperfusion (P<0.001) and were associated with poorer functional outcomes (adjusted common OR: 0.49, 95% CI: 0.24–0.99). Conclusions: An older thrombus delays reperfusion after mechanical thrombectomy for ischemic stroke. Adding therapies targeting thrombus maturation may improve the efficacy of mechanical thrombectomy.

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“…The concept is supported by clinical and basic studies using MRI and an animal model of DVT. The median value of the DVT volume calculated by MRI was 20 mL 66 . The value appears to be much larger than that of atherothrombosis.…”

Section: Vtementioning

confidence: 72%

Underlying mechanisms of thrombus formation/growth in atherothrombosis and deep vein thrombosis

Yamashita

Asada

2023

Pathology International

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Thrombosis remains a leading cause of death worldwide despite technological advances in prevention, diagnosis, and treatment. The traditional view of arterial thrombus formation is that it is a platelet-dependent process, whereas that of venous thrombus formation is a coagulation-dependent process. Current pathological and basic studies on atherothrombosis and venous thrombosis have revealed the diverse participation of platelet and coagulation activation mechanisms in both thrombus initiation and growth processes during clinical thrombotic events. Atherosclerotic plaque cellderived tissue factor contributes to fibrin formation and platelet aggregation. The degree of plaque disruption and a blood flow alteration promote atherothrombotic occlusion. While blood stasis/turbulent flow due to luminal stenosis itself initiates venous thrombus formation. The coagulation factor XI-driven propagation phase of blood coagulation plays a major role in venous thrombus growth, but a minor role in hemostasis. These lines of evidence indicate that atherothrombosis onset is affected by the thrombogenic potential of atherosclerotic plaques, the plaque disruption size, and an alteration in blood flow. Upon onset of venous thrombosis, enhancement of the propagation phase of blood coagulation under blood stasis and a hypercoagulable state contribute to large thrombus formation.

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High Signal Intensity on Diffusion-Weighted Images Reflects Acute Phase of Deep Vein Thrombus

Cited by 10 publications

References 29 publications

Comparison of gray scale versus Doppler ultrasound to detect deep venous thrombosis in lower extremities.

Comparison of gray scale versus Doppler ultrasound to detect deep venous thrombosis in lower extremities.

An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke

Underlying mechanisms of thrombus formation/growth in atherothrombosis and deep vein thrombosis

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