High serum uric acid levels increase the risk of metabolic syndrome in elderly women: The PRO.V.A study

Zurlo, Anna; Veronese, Nicola; Giantin, Valter; Maselli, Monica; Maggi, Stefania; Musacchio, Estella; Toffanello, Elena Debora; Sartori, Leonardo; Perissinotto, Egle; Crepaldi, Gaetano; Manzato, Enzo; Sergi, Giuseppe

doi:10.1016/j.numecd.2015.10.007

Cited by 37 publications

(21 citation statements)

References 42 publications

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“…Significant differences have been observed in the levels of SUA concentrations in men and women. Several studies have reported higher levels of SUA in men as compared to women [26,27,28,29,30,31,32,33], which is similar to our results. Similarly, sex-specific differences have also been reported with respect to association of SUA with CVD risk factors.…”

Section: Discussionsupporting

confidence: 92%

“…A retrospective analysis of the database from the Laboratory Information System—a database of data from a cohort of outpatient adults referred by general practitioners for routine medical check-ups for three years from 2005–2008—showed that triglycerides were significantly associated with circulating uric acid in women but not in men [35]. Similarly, a study conducted in elderly adults reported that high SUA levels predicted metabolic syndrome in older women but not men [31]. In our study, we observed a similar pattern of associations.…”

Section: Discussionmentioning

confidence: 99%

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Blueberry Consumption Affects Serum Uric Acid Concentrations in Older Adults in a Sex-Specific Manner

et al. 2016

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Blueberries are rich in antioxidants and may protect against disease. Uric acid accounts for about 50% of the antioxidant properties in humans. Elevated levels of serum uric acid (SUA) or hyperuricemia is a risk factor for cardiovascular disease (CVD). The aim was to determine the effect of blueberries on SUA in older adults. Participants (n = 133, 65–80 years) experiencing mild cognitive impairment (MCI) were randomized in a double-blind 6-month clinical trial to either blueberry or placebo. A reference group with no MCI received no treatment. The mean (SD) SUA at baseline were 5.45 (0.9), 6.4 (1.3) and 5.8 (1.4) mg/dL in reference, placebo, and treatment groups, respectively. Baseline SUA was different in men and women (6.25 (1.1) vs. 5.35 (1.1), p = 0.001). During the first three months, SUA decreased in the blueberry group and was significantly different from the placebo group in both men and women (p < 0.0003). Sex-specific differences became apparent after 3 months, when only men showed an increase in SUA in the blueberry group and not in the placebo (p = 0.0006) between 3 and 6 months. At 6 months SUA had rebounded in both men and women and returned to baseline levels. Baseline SUA was correlated with CVD risk factors, waist circumference and triglycerides (p < 0.05), but differed by sex. Overall, 6 m SUA changes were negatively associated with triglycerides in men, but not in women. Group-wise association between 6 m SUA changes and CVD risk factors showed associations with diastolic blood pressure, triglycerides and high-density lipoprotein (HDL) cholesterol in women of the Blueberry group but not in men or any sex in the placebo group. In summary, blueberries may affect SUA and its relationship with CVD risk in a sex-specific manner.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Blueberry Consumption Affects Serum Uric Acid Concentrations in Older Adults in a Sex-Specific Manner

et al. 2016

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“…In line with previous studies [21][22][23] we reported higher serum uric acid level in women with MetS, comparing to those without MetS. Moreover, in a prospective study conducted by Zurlo et al [24] high serum uric acid levels significantly and independently predicted MetS in older women, but not in men, over a 4.4-year follow-up.…”

Section: Discussionsupporting

confidence: 92%

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Jovanović¹,

Klisić²,

Kavarić³

et al. 2016

Tim Med Glas

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Summary:Aim: The data regarding the prevalence of metabolic syndrome (MetS) among postmenopausal women in Montenegro is limited. Therefore, the aim of this study was to evaluate this prevalence and to examine its association with serum uric acid level, an established cardiometabolic risk factor. Methods: A total of 242 postmenopausal women (aging 43-68) were included. Fasting glucose, lipid parameters, and uric acid were determined with the standard procedure. Blood pressure and anthropometric parameters were obtained. MetS was diagnosed according to the modified US National Cholesterol Education Program Adult Treatment Panel III guidelines. Results: The prevalence of MetS in postmenopausal women was 42.1%. The most prevalent component was abdominal obesity (65.3%), following by hypertension (systolic blood pressure and diastolic blood pressure accounting for 54.1% and 49.2% respectively), hyperglycemia (40.5%), and dyslipidemia (high triglycerides and low HDL-c level accounting for 30.2% and 25.2% respectively). Uric acid levels were significantly higher in postmenopausal women with MetS than in those without MetS (P<0.001). Moreover, a significantly higher number of patients with MetS as compared to subjects without diagnosed MetS across uric acid tertiles was found (χ2=27.02, P<0.001). Conclusion: MetS is highly prevalent among postmenopausal women in Montenegro and correlated with higher uric acid level. Abdominal obesity is the most prevalent feature of the syndrome. This suggests the importance of reducing obesity and lowering uric acid level in prevention of cardiometabolic diseases. Keywords:abdominal obesity, metabolic syndrome, postmenopausal, uric acid Sažetak:Cilj: Nema podataka o prevalenci metaboličkog sindroma (MetS) kod žena u periodu postmenopauze u Crnoj Gori. Stoga je cilj studije bio da se utvrdi ova prevalenca i ispita povezanost MetSa sa mokraćnom kiselinom u serumu, poznatim kardiometaboličkim faktorom rizika. Metode: U studiju su uključene 242 žene u postmenopauzi (starosti 43-68 godina). Glikemija našte, lipidni status i mokraćna kiselina su određivani standardnom procedurom. Mereni su i krvni pritisak i antropometrijski parametri. MetS je dijagnostikovan prema modifikovanim smernicama Američkog nacionalnog programa za edukaciju o holesterolu -Preporuke panela III za lečenje odraslih. Rezultati: Prevalenca MetS-a kod žena u postmenopauzi je iznosila 42,1%. Najučestalija komponenta je bila abdominalna gojaznost (65,3%), potom hipertenzija (sistolna -54,1% i dijastolna -49,2%), hiperglikemija (40,5%), dislipidemija (hipertrigliceridemija -30,2%) i niske vrednosti lipoproteina velike gustine (HDL-holesterol -25,2%). Srednje vrednosti serumske mokraćne kiseline bile su značajno više kod žena sa MetS-om u poređenju sa kontrolnom grupom (P<0,001). Takođe, značajno veći broj ispitanica sa MetS-om je zabeležen u tercilnoj grupi sa najvišom koncentracijom mokraćne kiseline u serumu (χ 2 =27,02; P<0,001). Zaključak: Zabeležena je visoka prevalenca MetS-a kod žena u postmenopauzi u Crnoj Gori, kao ...

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“…When children (10–15 years at baseline) were followed for 10 years, high SUA was a significant predictor of incident MS in male subjects [14]. On the other hand, when elderly hyperuricemic subjects above sixty-five years were followed for more than 4 years, only female subjects showed increased incidence of MS [15]. Another prospective study assessed 1511 men and women 55–80 years old, who were not affected initially by any of the components of MS.…”

Section: Uric Acid and Metabolic Syndromementioning

confidence: 94%

Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review

Din

Salem

Abdulazim

2017

Journal of Advanced Research

289

165

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High serum uric acid levels increase the risk of metabolic syndrome in elderly women: The PRO.V.A study

Cited by 37 publications

References 42 publications

Blueberry Consumption Affects Serum Uric Acid Concentrations in Older Adults in a Sex-Specific Manner

Blueberry Consumption Affects Serum Uric Acid Concentrations in Older Adults in a Sex-Specific Manner

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review

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