High Serum sTREM-1 Correlates With Myocardial Dysfunction and Predicts Prognosis in Septic Patients

Li, Zhenyu; Zhang, Enyuan; Hu, Yipeng; Liu, Yi; Chen, Bing

doi:10.1016/j.amjms.2016.01.023

Cited by 16 publications

(13 citation statements)

References 21 publications

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“…Of the 46 studies included in this review, 35 examined the association of brain natriuretic peptides (BNP, NT‐proBNP) with survival in patients with septic shock, presented in Table . The vast majority were prospective cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, increased mortality was observed in patients in which BNP increased from baseline values, or NT‐proBNP increased more than 30% from baseline values . Nonetheless, several studies have reported that there is no association between brain natriuretic peptides and subsequent mortality in patients with septic shock …”

Section: Discussionmentioning

confidence: 99%

“…Regarding publication bias, eight studies from those that fulfilled the inclusion criteria, reported that no significant difference in biomarker values was observed between survivors and non‐survivors. Of those, two regarded NT‐proBNP and six regarded BNP . Due to the heterogenicity in reported measures of effect, a funnel plot could not be plotted.…”

Section: Discussionmentioning

confidence: 99%

“…33 Nonetheless, several studies have reported that there is no association between brain natriuretic peptides and subsequent mortality in patients with septic shock. 13,19,22,38,40,43,44 In regard to the secondary outcome of assessing cardiac function, many studies report an association between the levels of brain natriuretic peptides and various indices of myocardial dysfunction. 17,18,28,29,32,36,37,39,41,46,48,49 Septic shock appears to be a strong stimulus for the release of natriuretic peptides, and their levels have been used successfully to distinguish between septic and cardiogenic shock, 54,55 as well as septic and other kinds of shock, 56 although this was not confirmed by other researchers.…”

Section: Discussionmentioning

confidence: 99%

“…33 In contrast to the aforementioned studies, eight studies did not find a significant association between brain natriuretic peptides levels and survival. 13,19,22,38,40,43,44 Of note were the study of McLean et al, which, despite demonstrating that daily measurements of BNP could not predict mortality or intensive care unit (ICU) length of stay, found that BNP levels were increased in patients with severe sepsis or septic shock independently of the presence of myocardial dysfunction. 38…”

Section: Association Of Brain Natriuretic Peptides With Survival Inmentioning

confidence: 99%

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The utility of brain natriuretic peptides in septic shock as markers for mortality and cardiac dysfunction: A systematic review

et al. 2019

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Objective To conduct a systematic review evaluating the utility of brain natriuretic peptide (BNP) and N‐terminal proBNP (NT‐proBNP) as biomarkers in adult patients with septic shock. Materials and Methods Pubmed/Medline databases were searched from inception to November 2018 using the search terms: (septic[Title/Abstract] AND shock[Title/Abstract]) AND bnp[Title/Abstract]) and (septic[Title/Abstract]) AND shock[Title/Abstract]) AND natriuretic[Title/Abstract]). No restriction was applied regarding date of publication. Comparative observational studies evaluating BNP and NT‐proBNP in patients with septic shock aged ≥18 years were eligible for inclusion. Bibliographies from the extracted articles were also reviewed to identify additional relevant publications. Results In total, 46 studies met all eligibility criteria and were included. A strong body of literature has demonstrated that in patients with septic shock, increased values of BNP and NT‐proBNP are associated with increased mortality. An increase from baseline BNP values has also been associated with increased mortality, whereas decreases from baseline values are not related to worse outcome. Brain natriuretic peptides have also been associated with cardiac dysfunction in patients with sepsis. Moreover, BNP values have been found to be significantly elevated in septic shock, regardless of cardiac dysfunction, and have been used to distinguish between septic and cardiogenic shock. Furthermore, BNP and NT‐proBNP are significantly increased in patients with septic shock, compared to patients with sepsis and severe sepsis. Conclusions BNP and NT‐proBNP appear to be reliable predictors of outcome in septic shock.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%