High serum lipopolysaccharide binding protein is associated with increased mortality in patients with decompensated cirrhosis

Abstract

Serum and AF LBP concentrations showed a high negative-predictive-value to exclude infection and SBP, respectively. High serum LBP was detected in patients without infection at presentation who died during the 90-day-follow-up period. Elevated serum LBP is a marker of short-term mortality in patients without overt bacterial infection.

Circulating levels of 3‐hydroxymyristate, a direct quantification of endotoxaemia in noninfected cirrhotic patients

“…22 Thus, recent studies have focused on the LPS-binding protein (LBP) as a surrogate of BT and as a prognostic factor in cirrhosis. 23,24 LBP peaks in plasma 2-3 days after BT and may remain increased up to 3 days later. 25 Moreover, we hypothesize that the synthesis of LBP by hepatocytes may be altered in patients with liver insufficiency.…”

“…This heterogeneity may be primarily due to technical difficulties in the quantification of circulating levels of LPS . Thus, recent studies have focused on the LPS‐binding protein (LBP) as a surrogate of BT and as a prognostic factor in cirrhosis . LBP peaks in plasma 2‐3 days after BT and may remain increased up to 3 days later .…”

Fluid Biomarkers for Predicting the Prognosis of Liver Cirrhosis

“…LBP is a predictor of LC prognosis. e authors of [91] detected LBP levels in 88 patients with decompensated cirrhosis including 18 patients with infection and the others without infection and found that, in noninfective patients, those with lower level of LBP had a lower 90-day mortality than the high level (48.0% vs. 24.4%), and only high LBP (HR: 8.1) and MELD (HR: 1.1) were predictors of mortality in multivariate analysis, but this association was not observed in infective patients. In 58 critically ill cirrhotic patients with severe sepsis, Chen et al [92] found that the cumulative survival rate at 28 days was higher in the high serum LBP group (>46 ng/mL) than that in the low serum LBP group (<46 ng/mL) (72.7% vs. 16.7%), with the AUROC of 0.809, sensitivity of 72.7%, and specificity of 83.3%.…”

Response to Lipopolysaccharide binding protein predicts decompensated cirrhosis mortality? It is too early

“…We appreciate the comments on our manuscript by Yan-Yan Xuan and colleagues, 1 as well as the opportunity to respond to them.…”

“…Thirdly, the aetiology of cirrhosis was already shown in our article. 1 The 48.9% was alcoholic, 27.3% viral, 15.9% non-alcoholicsteatohepatitis, 5.7% autoimmune disease, 1.1% cryptogenic and 1.1% Wilson's disease. The aetiology did not differ between patients with and those without infection.…”