High serum cardiac troponin T concentrations in preterm infants with respiratory distress syndrome

Trevisanuto, Daniele; Zaninotto, Martina; Altinier, Sara; Plebani, Mario; Zanardo, Vincenzo

doi:10.1080/713794580

Cited by 39 publications

(27 citation statements)

References 9 publications

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“…These findings are in keeping with those of Trevisanuto et al [23,24], who measured cardiac troponin T at 2, 4 and 7 days in preterm infants with respiratory distress syndrome. Although, their study used a second-generation assay and the levels were around 600 to 800 pg/mL on days 2 and 4, and by day 7 they had fallen to 260-290 pg/mL.…”

Section: Healthy Infantssupporting

confidence: 90%

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Sequential cardiac troponin T following delivery and its relationship with myocardial performance in neonates with respiratory distress syndrome

et al. 2005

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We measured serial cardiac troponin T in babies with respiratory distress syndrome and in "healthy" controls (no cardiorespiratory support required). We investigated relationships between cardiac troponin T and myocardial performance in respiratory distress syndrome. This was a prospective observational study at a large tertiary maternity unit that recruited 104 "healthy" babies from whom individual samples were collected. A further 24 infants with respiratory distress syndrome and 14 "healthy" preterm infants had serial sampling over the first three days. We measured fractional shortening in 14 of the infants with respiratory distress syndrome. Cardiac troponin T rose from a median (interquartile range) of 10 (10-11) pg/mL on day one to 34 (22-46) pg/mL by day three, p=0.005, in "healthy" babies. In respiratory distress syndrome levels were higher, 91 (46-135) pg/mL at 6 (5-7) hours of age, p<0.001, and remained so for all three days. In babies with respiratory distress syndrome on day one cardiac troponin T correlated negatively with fractional shortening, Rho=-0.831, p<0.001, but this correlation did not persist. In "healthy" babies there is a minimal rise of cardiac troponin T by day 3. In respiratory distress syndrome there is an early and sustained elevation of cardiac troponin T, with a negative relationship with fraction shortening, suggesting significant myocardial damage of antenatal/intrapartum origin, giving rise to measurable dysfunction.

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Section: Healthy Infantssupporting

confidence: 90%

“…Other research groups [17,23,24] have measured cardiac troponin T using first and second generation assays, while they found associations with asphyxia and respiratory distress syndrome. These assays were prone to the effects of haemolysis, icterus and renal insufficiency, making it difficult to compare results.…”

Section: Study Limitationsmentioning

confidence: 97%

Sequential cardiac troponin T following delivery and its relationship with myocardial performance in neonates with respiratory distress syndrome

et al. 2005

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“…However, as skeletal TnT is not expressed2, cTnT has been used to detect myocardial injury in the neonatal period 3 4 5. Theoretically, cTnI is unsuitable as a marker of myocyte damage in neonates because the dominant form of troponin I in fetal cardiac tissue is the slow twitch muscle skeletal TnI, which is downregulated with concurrent upregulation of cTnI expression during the first 9 months of postnatal life 6 7 8…”

mentioning

confidence: 99%

Cardiac troponin I at birth is of fetal-neonatal origin

Trevisanuto

Doglioni²,

Altinier³

et al. 2009

Archives of Disease in Childhood - Fetal and Neonatal Edition

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“…They also observed a significant relationship of troponin T levels with the use of vasopressors, mechanical ventilation, and high oxygenation index in patients with respiratory distress syndrome. The mean plasma troponin was 0.38 ng/mL in patients with respiratory distress versus 0.13 ng/mL in patients without respiratory distress ( P < 0.01) [2]. …”

Section: Discussionmentioning

confidence: 99%

“…RDS affects close to 50% of the VLBW infants; signs and symptoms of respiratory and cardiovascular disease are very similar [2], and decreased myocardial function and low cardiac output are common complications of conditions such as respiratory distress syndrome and perinatal asphyxia [3]. …”

Section: Introductionmentioning

confidence: 99%

Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant

Lopes¹,

Ramos

Moreira

et al. 2012

International Journal of Pediatrics

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Introduction. Respiratory distress are very common in Very-low-birth-weight (VLBW) infants and Myocardial injury may play a role in the disease outcome. Cardiac troponin T (cTnT) is the most useful marker of injury in adult population, but has not been extensively studied in this population. Aim. To study the role of cTnT in VLBW infants and its association with clinical outcomes. Methods. All VLBW infants admitted to our NICU were included in the study. Echocardiography and blood samples for cTnT determination were collected at 24 and 48 hours of life, and values >0.1 ng/mL were considered CTnT-positive values. Results. A total of 116 neonates had their blood samples collected. The median cTnT concentration within 24 hours was 0.191 (0.1–0.79) ng/mL and within 48 hours was 0.293 (0.1–1.0) ng/mL. A logistic regression analysis showed that PDA, low GA, and use of dopamine were independently associated with positive cTnT and abnormal Dopplerfluxometry and diuretics use had protective effects and was independently associated with troponin values. Conclusion. We observed a high prevalence of positivecTnT values in VLBW infants associated with illness severity. Our findings suggest that cTnT may be a useful and early marker of myocardial injury in VLBW infants.

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High serum cardiac troponin T concentrations in preterm infants with respiratory distress syndrome

Abstract: High cTnT concentrations in preterm infants with RDS suggest the presence of myocardial damage in this group of high-risk patients.

Cited by 39 publications

References 9 publications

Sequential cardiac troponin T following delivery and its relationship with myocardial performance in neonates with respiratory distress syndrome

Sequential cardiac troponin T following delivery and its relationship with myocardial performance in neonates with respiratory distress syndrome

Cardiac troponin I at birth is of fetal-neonatal origin

Cardiac Troponin T and Illness Severity in the Very-Low-Birth-Weight Infant

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