High serum adiponectin is associated with anemia development in chronic kidney disease: The results from the KNOW-CKD study

Kim, Hyoungnae; Yun, Hae‐Ryong; Park, Seohyun; Jhee, Jong Hyun; Park, Sun-Hee; Yoo, Tae‐Hyun; Lee, Kyu Beck; Kim, Yeong Hoon; Sung, Su Ah; Lee, Joongyub; Kang, Shin Wook; Choi, Kyu Hun; Ahn, Curie; Han, Seung Hyeok

doi:10.1016/j.cyto.2017.12.018

Cited by 8 publications

(13 citation statements)

References 47 publications

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“…It is reported that suchchange in adiponectin level is associated with loss of energy and protein and increased fluid volume in this group of patients [2,3]. Severalstudies [1,9]suggest a negative correlation between adiponectinand growth of hematopoietic stem cells. According to some studies, it might also regulate mass of bone and mesenchymal stem cell migration in the bone marrow.…”

Section: Introductionmentioning

confidence: 83%

“…Other causes might includeoverproduction of adiponectin in adipose tissue by amelioration of glomerular hypertrophy, through activation of adenosine 5'-monophosphate-activated protein kinase by AdipoR1 and activation of peroxisome proliferator-activated receptor (PPAR)-α signaling pathway by AdipoR2 (7). Several single nucleotide polymorphisms in the adiponectin gene are associated with increased risk of the development of diabetic nephropathy at ESRD [1,11]. A study by Zha et al, [12]is in consistencewith the results of the presentstudyin terms of supportingthe notion that the association of adiponectin with diabetic nephropathy may be due to the expression and regulation by specific factors that regulate adiponectin gene (AdipoQ) transcription,such asCCAAT-enhancer binding protein A, forkhead box O1 (FOXO1), and specificity protein 1.…”

Section: Discussionmentioning

confidence: 99%

“…Erythroid disorders, including anemia, are mostly encountered in the general clinical setting. Anemia is affected by hematopoietic growth factor erythropoietin (EPO) [1,2]. Some people have anemia that is unrelated to nutrient deficiency or chronic metabolic diseases, but other factorsmay contribute to cause anemia [3].…”

Section: Introductionmentioning

confidence: 99%

“…According to some studies, it might also regulate mass of bone and mesenchymal stem cell migration in the bone marrow. Therefore, it probablyindirectly enhances erythropoiesis process rather than having a direct effect on erythrocytes [1,9]. In chronic kidney disease (CKD) and diabetic patients, level of circulating adiponectin is paradoxically fluctuated and the role of adiponectin is complex to realize [1].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it probablyindirectly enhances erythropoiesis process rather than having a direct effect on erythrocytes [1,9]. In chronic kidney disease (CKD) and diabetic patients, level of circulating adiponectin is paradoxically fluctuated and the role of adiponectin is complex to realize [1]. Therefore, we aimed to evaluate adiponectin level and blood erythroid parametersand determine whether adiponectinis associated with anaemia and Hb concentration in diabetic nephropathy patients, since such an associationseems to be unclear till now.…”

Section: Introductionmentioning

confidence: 99%

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High AdiponectinHormone Modulation ofBlood Erythroid Parameters and its Relation with Erythropoietin in Patients with Diabetic Nephropathy

Hayder

Kareem

2020

eijs

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Background: Serum adiponectin is a hormone of adipose tissue that activateslipid metabolism and exertsphysiological functions. Its level usually fluctuates in several metabolic diseases,including renal insufficiency and diabetes; it loses its protective role against diseases and becomes a potentially risk factor for erythroid abnormalities. Objectives: The study was designed to assess the association between adiponectin hormone, blood erythroid and various parameters in groups of patients. Method:The study included 130 patientsand 42 healthy subjects. Parameters of serum adiponectin, erythropoietin (EPO), red blood cells (RBC), hemoglobin (Hb), hematocrit (Hct), renal function, serum insulin, fasting blood sugar (FBS), glycated hemoglobin % (HbA1c%) and homeostatic model assessment of insulin resistance (HOMA-IR) were estimated in all groups. Result: Statistical analysis showed that high level of adiponectin was significantly associated with erythroid-related variables (EPO, RBC, Hb and Hct) in patients groups when compared with the control. Receiver Operating Characteristic (ROC) curve analysis showed that adiponectin is a significant risk factor for anemia progression in non-insulin dependent diabetes mellitus (NIDDM), end stage renal disease (ESRD)and diabetic nephropathy patients. Conclusion: We suggest that high serum adiponectin level is dependently associated with EPO level and erythroid abnormalities in NIDDM, kidney failure and diabetic nephropathy patients. The present findings regarding ROC curve analysis of adiponectin suggested that this hormone could represent a risk factor for erythroid abnormality in diabetic nephropathy at ESRD.

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High AdiponectinHormone Modulation ofBlood Erythroid Parameters and its Relation with Erythropoietin in Patients with Diabetic Nephropathy

Hayder

Kareem

2020

eijs

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Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease

Kim

Han²,

Kim

et al. 2021

Sci Rep

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Hyperadiponectemia is paradoxically associated with renal disease progression and mortality in chronic kidney disease (CKD). Its association with health-related quality of life (HR-QOL) is unknown. This study aimed to verify the association between adiponectin and HR-QOL in Korean pre-dialysis CKD cohort. This cross-sectional study analyzed 1551 pre-dialysis CKD patients from KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease). Participants were categorized into three tertiles (T1–T3) according to adiponectin levels. HR-QOL was assessed using SF-36. High physical component summary (PCS) and mental component summary (MCS) were defined as highest quartile of each score. Multivariate logistic regression was used to analyze odds ratio (OR) and 95% confidence interval (CI) for high PCS and MCS. Prevalence of high PCS were 33.3%, 27.5%, and 17.0% and that of high MCS were 31.7%, 24.8%, and 21.3% for T1, T2, and T3 (both p for trend < 0.001). The adjusted OR [95% CI] of T1 and T2 in reference to T3 were 1.56 [1.09–2.23] and 1.19 [0.85–1.68] for high PCS and 1.19 [0.85–1.68] and 0.94 [0.68–1.29] for high MCS. Serum adiponectin level was inversely associated with physical HR-QOL in Korean pre-dialysis CKD patients. This relationship was independent of various cardiovascular risk factors.

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Critical role of triglycerides for adiponectin levels in hepatitis C: a joint study of human and HCV core transgenic mice

Chang

Pao

et al. 2021

BMC Immunol

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Background Both hepatitis C virus (HCV) infection and adiponectin are critically involved in metabolism. The reversal and associations of altering adiponectin levels after sustained virological responses (SVRs) following direct-acting antivirals (DAA) in HCV-infected patients remained elusive. Methods A joint study was conducted in a prospective cohort of 427 HCV-infected patients and a line of HCV core transgenic mice. Results Of 427, 358 had completed a course of DAA therapy and 353 had SVRs. At baseline, male sex (95% CI β: − 1.44 to − 0.417), estimated glomerular filtration rate (eGFR) (− 0.025 to − 0.008), triglycerides (− 0.015 to − 0.005), and fibrosis-4 levels (0.08–0.297) were associated with adiponectin levels; BMI (0.029–0.327) and triglycerides levels (0.01–0.03) were associated with homeostatic model assessment for insulin resistance (HOMA-IR) in HCV-infected patients. At 24-week post-therapy, in SVR patients, male sex (− 1.89 to − 0.5) and eGFR (− 0.02 to − 0.001) levels were associated with adiponectin levels, levels of BMI (0.094–0.335) and alanine transaminase (0.018–0.078) were associated with HOMA-IR; compared with baseline levels, adiponectin levels decreased (6.53 ± 2.77 vs. 5.45 ± 2.56 μg/mL, p < 0.001). In 12-month-old HCV core transgenic mice with hepatic steatosis, triglyceride levels (0.021–0.111) were associated with adiponectin levels, and hepatic adipopnectin expression was comparable with that of control mice. Conclusions Triglycerides and hepatic fibrosis are associated with HCV-specific alteration of adiponectin levels, and adiponectin may affect insulin sensitivity through triglycerides during HCV infection. In DAA-treated patients, after SVR, adiponectin levels decreased and the linking function of triglycerides between adiponectin and insulin sensitivity vanished. Moreover, HCV core with hepatic steatosis might affect extrahepatic adiponectin expression through triglycerides.

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High serum adiponectin is associated with anemia development in chronic kidney disease: The results from the KNOW-CKD study

Cited by 8 publications

References 47 publications

High AdiponectinHormone Modulation ofBlood Erythroid Parameters and its Relation with Erythropoietin in Patients with Diabetic Nephropathy

High AdiponectinHormone Modulation ofBlood Erythroid Parameters and its Relation with Erythropoietin in Patients with Diabetic Nephropathy

Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease

Critical role of triglycerides for adiponectin levels in hepatitis C: a joint study of human and HCV core transgenic mice

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