High seroprevalence of Helicobacter pylori infection in non-institutionalised children with mental retardation

Luzza, Francesco; Concolino, Daniela; Imeneo, Maria; Pascuzzi, A.; Pietragalla, E.; Pallone, Francesco; Strisciuglio, Pietro

doi:10.1111/j.1469-0691.2004.00915.x

Cited by 15 publications

(9 citation statements)

References 21 publications

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“…The present study reveals that institutionalization within rehabilitation centers is not a predictor for G. lamblia or H. pylori among mentally challenged individuals in Alexandria, Egypt. Our finding is in line with Luzza et al [42], who reported that H. pylori is highly prevalent among mentally challenged children, irrespective of their institutionalization status. In contrast, Wallace et al [43] reported that past or current institutionalization of intellectually disabled adults is an environmental risk factor associated with H. pylori infection.…”

Section: Discussionsupporting

confidence: 93%

G. lamblia and H. pylori infections among mentally challenged individuals in rehabilitation centers in Alexandria, Egypt

Hassanein

Shehata

Abdul‐Ghani

2017

J Infect Dev Ctries

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Introduction: Concomitant infections with pathogens are common, particularly when there are shared modes of infection or when one pathogen promotes the other. Residence among closed-type care institutions may pose an additional risk of such infections. Mentally challenged patients in rehabilitation centers constitute one of the special needs groups exposed to parasitic infections, including giardiasis. Several studies reported concomitant infection with G. lamblia and H. pylori worldwide and in Egypt; however, the co-existence of these two pathogens among mentally challenged individuals remains unexplored. The present study aimed to study the prevalence and association between G. lamblia and H. pylori among mentally challenged patients in rehabilitation centers in Alexandria, Egypt. Methodology: 200 individuals admitted to four mental rehabilitation centers in the period from June 2013 to January 2014, who guardians gave informed consent, were recruited. Stool samples were collected and subjected to trichrome stain for G. lamblia and to antigen detection for H. pylori. Results: The overall prevalence rates of G. lamblia and H. pylori were 8.5% and 24.0%, respectively. Monoinfection rates were 5.5% for G. lamblia and 21.0% for H. pylori, while concomitant infection with both species was detected in only 3.0% of cases. However, individuals who were H. pylori-positive were about two times more likely to be infected with G. lamblia than those who were H. pylori-negative (12.5% vs. 7.2%). Conclusions: Mentally challenged individuals in Alexandria harbouring H. pylori are about two times more likely to be exposed to G. lamblia. Large-scale studies are recommended to confirm this association.

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Section: Discussionsupporting

confidence: 93%

G. lamblia and H. pylori infections among mentally challenged individuals in rehabilitation centers in Alexandria, Egypt

Hassanein

Shehata

Abdul‐Ghani

2017

J Infect Dev Ctries

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“…They reported that 50% of the patients were seropositive, which was confirmed by C-UBT test in 95%. Luzza et al also studied 42 children with Down syndrome (34 males and 50 females 2-18 years) in terms of H. pylori in 2004 and concluded that 50% of the patients were seropositive which was confirmed by C-UBT test in 95%, while in the current study 54.6% were seropositive, and it was also confirmed by C-UBT test (12). Considering that UBT is an expensive test, in the first step the current study used ELISA test then UBT test was used to confirm the positive cases.…”

Section: Discussionsupporting

confidence: 60%

“…In addition, H. pylori can cause ischemic heart disease (IHD), chronic obstructive pulmonary disease (COPD), iron deficiency anemia (IDA), cerebral and neurological disease such as Alzheimer and migraine (9)(10)(11). Owing to the fact that patients with Down syndrome have genetic defects and physical problems, it seems vital to prevent the prevalence of infection among them; hence, early detection of the infection in such patients can prevent the spread of it (12). Due to the life condition of the institutionalized children, transmission of H. pylori can occurred easily; therefore, it is a serious matter to recognize and determine transmission risk factors of H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori Infection in Patients With Down Syndrome and Mental Retardation

Fayaz

Gachkar

Roodsari

et al. 2014

Arch Clin Infect Dis

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Background: Clinical and epidemiological data indicate that Helicobacter pylori (H. pylori) are acquired during childhood and remains for the life time of the host. Patients with physical and mental disabilities may be particularly exposed to this microorganism, because of different dietary, abilities, living, and sanitary condition. Objectives: The current study aimed to investigate the prevalence of H. pylori infection among institutionalized patients with Down syndrome and mental retardation. Patients and Methods: Seventy five institutionalized patients with Down syndrome and mental retardation, with the age range of < 10 to 50 years were selected from welfare Center, an institute for caring mental retardation and Down syndrome patients. Seventy five out patients were also included as controls too. The control population was from the same geographical area as the study group, and had comparable socioeconomic features. Sanitary condition and personal hygiene of both the intervention and control groups were considered. Serum immunoglobulin G (IgG) produced in response to H. pylori infection was measured, with the Helori-test IgG with 92% sensitivity and 95% specificity; urea breath test (UBT) was also done for all. Results: The differences between the groups were compared by t-test and X 2 test. Seropositivity for H. pylori was significantly higher in patients with Down syndrome and mental retardation than in those of the control group (P < 0.001) as the socioeconomic features did not differ between the two groups, this can be a strong consideration of the validity of this comparison (the current study showed that out of 75 specimens, 41 cases were positive by Elisa test; accordingly, UBT test results were positive too). Conclusions: The current study indicated that H. pylori infection occurs at a higher rate in patients with Down syndrome and mental retardation. This may provide more reasons to control the transmission of H. pylori among them.

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“…Susceptibility to infections increases risks during chemotherapy, counteracting the increased DS cancer cell susceptibility to drugs 72 . Also, this potentially explains the increased rates of stomach cancer in some studies, despite the gastric cancer-associated trefoil factor (TFF) family of tumour suppressor genes being on HSA21, as these genes are silenced by Helicobacter pylori infection 73 , and there is evidence of higher rates of H. pylori infection in DS 74,75 .…”

Section: Ds Biology Predicts Cancer Pronenessmentioning

confidence: 99%

Tumorigenesis in Down's syndrome: big lessons from a small chromosome

2012

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If assessed by a number of criteria for cancer predisposition, Down's syndrome (DS) should be an overwhelmingly cancer-prone condition. Although childhood leukaemias occur more frequently in DS, paradoxically, individuals with DS have a markedly lower incidence of most solid tumours. Understanding the mechanisms that are capable of overcoming such odds could potentially open new routes for cancer prevention and therapy. In this Opinion article, we discuss recent reports that suggest unique and only partially understood mechanisms behind this paradox, including tumour repression, anti-angiogenic effects and stem cell ageing and availability.

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High seroprevalence of Helicobacter pylori infection in non-institutionalised children with mental retardation

Cited by 15 publications

References 21 publications

G. lamblia and H. pylori infections among mentally challenged individuals in rehabilitation centers in Alexandria, Egypt

G. lamblia and H. pylori infections among mentally challenged individuals in rehabilitation centers in Alexandria, Egypt

Prevalence of Helicobacter pylori Infection in Patients With Down Syndrome and Mental Retardation

Tumorigenesis in Down's syndrome: big lessons from a small chromosome

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