High-sensitivity troponin T in asymptomatic severe aortic stenosis

Ferrer-Sistach, Elena; Lupón, Josep; Cediel, Germán; Teis, Albert; Gual, Francisco; Serrano, Sílvia; Vallejo, Nuria Garatachea; Juncà, Gladys; López-Ayerbe, Jorge; Bayés‐Genís, Antoni

doi:10.1080/1354750x.2019.1567818

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…Importantly, three studies found that Troponin was not significantly associated with allcause mortality [16,50,54]. Among the studies that reported MACE, all found a significant association between Troponin level and MACE [60,64,74], with one study describing a 10fold risk of MACE in those with Troponin > 10 ng/L [64].…”

Section: Troponinmentioning

confidence: 99%

“…Importantly, only one study found that BNP was not significantly associated with all-cause mortality [26]. Similarly, 23 of the NT-proBNP studies reported all-cause mortality [6,17,22,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] and the other 10 studies reported composite mortality outcomes such as MACE [59][60][61][62][63][64][65][66][67][68]. Again, only one study found that NT-proBNP was not significantly associated with all-cause mortality [52].…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

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Biomarkers Associated with Mortality in Aortic Stenosis: A Systematic Review and Meta-Analysis

et al. 2021

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The optimal timing of aortic valve replacement (AVR) remains controversial. Several biomarkers reflect the underlying pathophysiological processes in aortic stenosis (AS) and may be of use as mortality predictors. The aim of this systematic review and meta-analysis is to evaluate the blood biomarkers utilised in AS and assess whether they associate with mortality. PubMed and Embase were searched for studies reporting baseline biomarker level and mortality outcomes in patients with AS. A total of 83 studies met the inclusion criteria and were systematically reviewed. Of these, 21 reporting brain natriuretic peptide (BNP), N-terminal pro B-type natriuretic peptide (NT-proBNP), Troponin and Galectin-3 were meta-analysed. Pooled analysis demonstrated that all-cause mortality was significantly associated with elevated baseline levels of BNP (HR 2.59; 95% CI 1.95–3.44; p < 0.00001), NT-proBNP (HR 1.73; 95% CI 1.45–2.06; p = 0.00001), Troponin (HR 1.65; 95% CI 1.31–2.07; p < 0.0001) and Galectin-3 (HR 1.82; 95% CI 1.27–2.61; p < 0.001) compared to lower baseline biomarker levels. Elevated levels of baseline BNP, NT-proBNP, Troponin and Galectin-3 were associated with increased all-cause mortality in a population of patients with AS. Therefore, a change in biomarker level could be considered to refine optimal timing of intervention. The results of this meta-analysis highlight the importance of biomarkers in risk stratification of AS, regardless of symptom status.

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Section: Troponinmentioning

confidence: 99%

Section: Natriuretic Peptidesmentioning

confidence: 99%

Biomarkers Associated with Mortality in Aortic Stenosis: A Systematic Review and Meta-Analysis

et al. 2021

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“…Although additional technics like the echocardiographic assessment of LV function, cardiopulmonary test, risk score (CURRENT-AS), and biomarkers might improve diagnostic, their role in AAS management requires further investigation to justify a class I indication for surgery instead of classic ET [31][32][33][34][35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Exercise test in patients with asymptomatic aortic stenosis – clinically useful or not?

Orłowska−Baranowska¹,

Baranowski²,

Hryniewiecki³

2021

Polish Archives of Internal Medicine

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only.

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“…Elevated levels of hs-cTnT have provided solid evidence of their prognostic capabilities in patients with various cardiovascular diseases, including those with moderate-tosevere AS, independent of HF and PH [85]. Although elevated circulating hs-cTnT levels (>10 ng/L) in patients with severe aortic stenosis were strongly associated with high risks of cardiovascular events within one year [86,87], a multiple biomarker model constructed from NPs and hs-cTnT is considered more predictive for these patients [88]. This approach seems promising to guide the treatment of AS, including TAVR [89].…”

Section: Biomarkersmentioning

confidence: 99%

Severe Aortic Valve Stenosis and Pulmonary Hypertension: A Systematic Review of Non-Invasive Ways of Risk Stratification, Especially in Patients Undergoing Transcatheter Aortic Valve Replacement

Boxhammer

Berezin

Paar

et al. 2022

JPM

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Patients with severe aortic valve stenosis and concomitant pulmonary hypertension show a significantly reduced survival prognosis. Right heart catheterization as a preoperative diagnostic tool to determine pulmonary hypertension has been largely abandoned in recent years in favor of echocardiographic criteria. Clinically, determination of echocardiographically estimated systolic pulmonary artery pressure falls far short of invasive right heart catheterization data in terms of accuracy. The aim of the present systematic review was to highlight noninvasive possibilities for the detection of pulmonary hypertension in patients with severe aortic valve stenosis, with a special focus on cardiovascular biomarkers. A total of 525 publications regarding echocardiography, cardiovascular imaging and biomarkers related to severe aortic valve stenosis and pulmonary hypertension were analyzed in a systematic database analysis using PubMed Central®. Finally, 39 publications were included in the following review. It was shown that the current scientific data situation, especially regarding cardiovascular biomarkers as non-invasive diagnostic tools for the determination of pulmonary hypertension in severe aortic valve stenosis patients, is poor. Thus, there is a great scientific potential to combine different biomarkers (biomarker scores) in a non-invasive way to determine the presence or absence of PH.

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High-sensitivity troponin T in asymptomatic severe aortic stenosis

Cited by 12 publications

References 24 publications

Biomarkers Associated with Mortality in Aortic Stenosis: A Systematic Review and Meta-Analysis

Biomarkers Associated with Mortality in Aortic Stenosis: A Systematic Review and Meta-Analysis

Exercise test in patients with asymptomatic aortic stenosis – clinically useful or not?

Severe Aortic Valve Stenosis and Pulmonary Hypertension: A Systematic Review of Non-Invasive Ways of Risk Stratification, Especially in Patients Undergoing Transcatheter Aortic Valve Replacement

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