High-sensitivity cardiac troponin I is a biomarker for increased arterial stiffness in systemic lupus erythematous women with normal kidney function

Sabio, JM; Rios, Carlos; Medina-Casado, Marta; García, María del Mar; Cáliz-Cáliz, Rafael; Díaz-Chamorro, Antonio

doi:10.1007/s00296-022-05204-2

Cited by 6 publications

(6 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a smaller study of 63 SLE patients with low CV risk profile like ours, high hs-troponin levels were associated with the presence of carotid atherosclerotic lesions [34]. In another study, Sabio JM et al (2023) demonstrated higher arterial stiffness in SLE patients with detectable values of hstroponin compared to controls [35]. Notably, both studies used the dichotomous values of detectable and non-detectable hs-troponin levels for analysis.…”

Section: Discussionmentioning

confidence: 64%

Echocardiography myocardial work and cardiac biomarkers indicate subclinical systolic myocardial dysfunction in patients with systematic lupus erythematous

Kadoglou,

Dimopoulou,

Korakianitis

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Systemic lupus erythematosus (SLE) is characterized by inflammation and cardiovascular complications. Our study aimed to investigate subclinical and early indicators of systolic myocardial dysfunction in SLE patients using advanced echocardiographic methods and biomarkers. Methods: In this cross-sectional study, we enrolled 102 SLE patients without known cardiac impairment and 51 healthy controls. Demographics, disease characteristics, laboratory results, disease activity (SLEDAI) and organ damage (SDI) indices were recorded. Left ventricular global longitudinal strain (GLS) and myocardial work indices were assessed by utilizing speckle tracking echocardiography. In addition, high sensitivity C-reactive protein (hsCRP), high sensitivity troponin (hsTn) and N-terminal-pro B-type natriuretic peptide (NT-proBNP) levels were measured in blood samples. Results: In comparison to controls, SLE patients had significantly higher GLS (-19.94±2.71%vs-21.15±1.55%, p&lt;0.001) and global wasted work (GWW) (94±71mmHg%vs71±49 mmHg%, p=0.025). Notably, NT-proBNP and hsTn were threefold and twofold higher in SLE group compared to control group, respectively (p&lt;0.001). Within SLE cohort, patients with at least moderate disease activity (SLEDAI≥4) both biomarkers were significantly elevated than those with low disease activity (SLEDAI&lt;4). Conclusion: Advanced echocardiographic parameters combined with specific biomarkers have a promising role in detecting systolic dysfunction at an early phase in SLE patients, potentially enabling timely interventions to mitigate cardiovascular risk.

show abstract

Section: Discussionmentioning

confidence: 64%

Echocardiography myocardial work and cardiac biomarkers indicate subclinical systolic myocardial dysfunction in patients with systematic lupus erythematous

Kadoglou,

Dimopoulou,

Korakianitis

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Sabio et al evaluated the correlations between high-sensitivity cardiac troponin I (hs-cTnI) and PWV CF. Their study found that the SLE group had higher levels of hs-cTnI compared to the control group, while PWV showed no significant differences between the groups [ 58 ]. Similar results were obtained in two studies where PWV values correlated with higher hs-cTnI [ 19 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

“…Their study found that the SLE group had higher levels of hs-cTnI compared to the control group, while PWV showed no significant differences between the groups [ 58 ]. Similar results were obtained in two studies where PWV values correlated with higher hs-cTnI [ 19 , 58 ]. However, PWV was higher in the SLE group.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Arterial Stiffness and Biochemical Markers in Systemic Lupus Erythematosus in the Diagnosis of Subclinical Atherosclerosis

Blachut,

Przywara-Chowaniec,

Mazurkiewicz

et al. 2024

JPM

View full text Add to dashboard Cite

Patients with systemic lupus erythematosus (SLE) are 2–10 times more likely to develop cardiovascular disease (CVD) than the general population. The assessment of the risk of developing CVD is an important direction for further clinical management. The study was conducted retrospectively and included patients with SLE. The aim of the study was to assess the measurements of pulse wave velocity (PWV), carotid intima-media thickness (CIMT), ankle–brachial index (ABI) and biochemical parameters. Subclinical atherosclerosis was also assessed. The study included 98 patients with SLE with an age- and sex-matched control group of 68 healthy adults. Statistical significance was found in the SLE group and the controls for N-terminal fragment of pro-B-type natriuretic peptide (NT proBNP) (144.87 vs. 36.41 pg/mL, p = 0.0018), high-sensitivity cardiac troponin (hs-cTn) (25.43 vs. 6.38 ng/L, p = 0.0303) and D-Dimer levels (0.73 vs. 0.36 µg/mL, p = 0.0088), left CIMT (1.03 vs. 0.62 mm, p < 0.0001), right CIMT (0.93 vs. 0.63 mm, p < 0.0001) and PWV CF (9.74 vs. 7.98 m/s, p = 0.0294). A positive correlation was found between NT proBNP and PWV CF (r = 0.6880, p = 0.0498) and hs-cTn and PVW carotid-femoral (CF) (r = 0.8862, p = 0.0499) in SLE. A positive correlation was reported between PWV CF and systolic blood pressure (r = 0.5025, p = 0.0487). The measurement of carotid–femoral PWV is a simple, non-invasive, and reproducible method and may independently predict future CVD events and their cause. Further studies are warranted to establish the prognostic value of PWV in patients with SLE, as it may be superior to CIMT measurements in the early stages of vascular disorders.

show abstract

“…It has been found that, among women diagnosed with systemic lupus erythematosus, the percentage of patients with increased PWV was significantly higher among patients with a detectable troponin I level than among patients with an undetectable troponin I level (38% vs. 12%; p = 0.024) [ 119 ].…”

Section: Cardiac Troponin Serum Level and Subclinical Cardiovascular ...mentioning

confidence: 99%

Cardiac Troponin Serum Concentration Measurement Is Useful Not Only in the Diagnosis of Acute Cardiovascular Events

Jakubiak

2024

JPM

View full text Add to dashboard Cite

Cardiac troponin serum concentration is the primary marker used for the diagnosis of acute coronary syndrome. Moreover, the measurement of cardiac troponin concentration is important for risk stratification in patients with pulmonary embolism. The cardiac troponin level is also a general marker of myocardial damage, regardless of etiology. The purpose of this study is to conduct a literature review and present the most important information regarding the current state of knowledge on the cardiac troponin serum concentration in patients with chronic cardiovascular disease (CVD), as well as on the relationships between cardiac troponin serum concentration and features of subclinical cardiovascular dysfunction. According to research conducted to date, patients with CVDs, such as chronic coronary syndrome, chronic lower extremities’ ischemia, and cerebrovascular disease, are characterized by higher cardiac troponin concentrations than people without a CVD. Moreover, the literature data indicate that the concentration of cardiac troponin is correlated with markers of subclinical dysfunction of the cardiovascular system, such as the intima–media thickness, pulse wave velocity, ankle–brachial index, coronary artery calcium index (the Agatston score), and flow-mediated dilation. However, further research is needed in various patient subpopulations and in different clinical contexts.

show abstract

High-sensitivity cardiac troponin I is a biomarker for increased arterial stiffness in systemic lupus erythematous women with normal kidney function

Cited by 6 publications

References 49 publications

Echocardiography myocardial work and cardiac biomarkers indicate subclinical systolic myocardial dysfunction in patients with systematic lupus erythematous

Echocardiography myocardial work and cardiac biomarkers indicate subclinical systolic myocardial dysfunction in patients with systematic lupus erythematous

Assessment of Arterial Stiffness and Biochemical Markers in Systemic Lupus Erythematosus in the Diagnosis of Subclinical Atherosclerosis

Cardiac Troponin Serum Concentration Measurement Is Useful Not Only in the Diagnosis of Acute Cardiovascular Events

Contact Info

Product

Resources

About