Cardiac Troponin Serum Concentration Measurement Is Useful Not Only in the Diagnosis of Acute Cardiovascular Events

Jakubiak, Grzegorz K.

doi:10.3390/jpm14030230

Cited by 10 publications

(5 citation statements)

References 138 publications

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“…Розрізняють три типи специфічних білків: тропонін С (TnC), тропонін I (TnI) і тропонін Т (TnT). Значна кількість вчених вважає, що тропонін I є найефективнішим діагностичним маркером пошкодження міокарду (Gavazza et al, 2020;Jakubiak, 2024).…”

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Biochemical changes in the blood of domestic dogs with cardiomyopathy in the setting of obesity

Zarytskyi

2024

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In clinical settings, cardiac biomarkers with high sensitivity and specificity can be used to predict or diagnose heart disease. In humane clinical practice, troponins I and T have been used as predictors of heart disease, and the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) is also considered the most reliable predictor of heart disease. Veterinary cardiac biomarkers are not yet widely used by practitioners in the diagnosis of heart disease, but this does not negate the high informative value of specific cardiac parameters such as canine N-terminal pro-B-type natriuretic peptide (cNT-proBNP) and canine cardiac troponin I (ccTnI). Given the above, there is a need to conduct biochemical blood tests for cardiac pathology in dogs. The aim of the study was to determine specific parameters (cNT-proBNP and ccTnI) and blood lipidogram of domestic dogs with cardiomyopathy in the setting of obesity. The analysis of blood tests showed an increase in the content of ccTnI by more than 20 times (Р < 0.001) and cNT-pro BNP by 17.6 times (Р < 0.001) in domestic dogs with cardiomyopathy in the setting of obesity. According to the results of lipidogram determination, the dogs of the experimental group showed an increase in total cholesterol by 66.9 %, low-density lipoprotein (LDL) by 8.4 times, and very low-density lipoprotein (VLDL) by 4.2 times. The studies showed significant changes in blood biochemical parameters in cardiomyopathy in domestic dogs with obesity, which confirms the diagnostic value of these biomarkers. The research results deserve the attention of the veterinary community of practitioners and can be used in the diagnosis and subsequent prognosis of heart disease in the future.

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Biochemical changes in the blood of domestic dogs with cardiomyopathy in the setting of obesity

Zarytskyi

2024

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“…Values can be elevated in chronic kidney disease, chronic coronary syndrome, and other chronic conditions. Also, diagnostic tests that indicate potential dysfunction of cardiovascular functionality (e.g., intima/media thickness, ankle brachial index, and calcium score) correlate well with cardiac troponins in the blood [7].…”

Section: Introductionmentioning

confidence: 99%

Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity

Svaguša,

Žarak,

Šušnjar

et al. 2024

JCM

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Background: It has recently been shown that cardiac-specific troponin I concentrations in first morning urine samples can be measured with commercially available tests. Due to their accumulation in the first morning urine, scientific papers indicate a potential predictive value for cardiovascular diseases. Therefore, the aim of this study was to compare the concentration of cardiac troponin I in the first morning urine in patients with severe aortic stenosis and the healthy population. Patients and Methods: Blood and first morning urine samples were collected from 34 healthy individuals (17 female) at University Hospital Merkur and 25 patients with severe aortic stenosis (14 female) before surgical treatment at University Hospital Dubrava. Cardiac troponin I and T values were determined using high-sensitivity assays using commercially available Abbott and Roche tests. Results: Patients with severe aortic stenosis had significantly lower troponin I concentrations in the first morning urine samples (0.3 ng/L (0.1–0.6)) as compared to the healthy population (15.2 ng/L (8.4–19.9)) (p < 0.001). There was no statistically significant difference in troponin T concentrations between healthy individuals and patients with severe aortic stenosis. In parallel, both I and T plasma troponin concentrations were significantly higher in patients with severe aortic stenosis. Conclusions: In patients with severe aortic stenosis, cardiac troponin I values in the first morning urine are significantly lower than in healthy subjects.

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“…Besides this, novel echocardiographic parameters (e.g., speckle tracking) may be useful to identify cardiac changes due to HHD at an early stage. It is also worth noting that the search for markers of subclinical dysfunction of the cardiovascular system is gaining increasing interest, and random measurement of biomarkers like cardiac troponin may be useful in this regard [13]. Prompt therapy may inhibit cardiac remodeling and attenuate cardiovascular risk [14].…”

Section: Introductionmentioning

confidence: 99%

Challenges in Echocardiography for the Diagnosis and Prognosis of Non-Ischemic Hypertensive Heart Disease

Kadoglou,

Mouzarou,

Hadjigeorgiou

et al. 2024

JCM

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It has been well established that arterial hypertension is considered as a predominant risk factor for the development of cardiovascular diseases. Despite the link between arterial hypertension and cardiovascular diseases, arterial hypertension may directly affect cardiac function, leading to heart failure, mostly with preserved ejection fraction (HFpEF). There are echocardiographic findings indicating hypertensive heart disease (HHD), defined as altered cardiac morphology (left ventricular concentric hypertrophy, left atrium dilatation) and function (systolic or diastolic dysfunction) in patients with persistent arterial hypertension irrespective of the cardiac pathologies to which it contributes, such as coronary artery disease and kidney function impairment. In addition to the classical echocardiographic parameters, novel indices, like speckle tracking of the left ventricle and left atrium, 3D volume evaluation, and myocardial work in echocardiography, may provide more accurate and reproducible diagnostic and prognostic data in patients with arterial hypertension. However, their use is still underappreciated. Early detection of and prompt therapy for HHD will greatly improve the prognosis. Hence, in the present review, we shed light on the role of echocardiography in the contemporary diagnostic and prognostic approaches to HHD.

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Cardiac Troponin Serum Concentration Measurement Is Useful Not Only in the Diagnosis of Acute Cardiovascular Events

Cited by 10 publications

References 138 publications

Biochemical changes in the blood of domestic dogs with cardiomyopathy in the setting of obesity

Biochemical changes in the blood of domestic dogs with cardiomyopathy in the setting of obesity

Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity

Challenges in Echocardiography for the Diagnosis and Prognosis of Non-Ischemic Hypertensive Heart Disease

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