High-sensitivity C-reactive protein use in cardiovascular risk screening at 6 to 12 months postpartum following hypertensive disorders of pregnancy

JOHNSTONE, Ainsley M.; Pudwell, Jessica; Ackerman-Banks, Christina; Lundsberg, Lisbet S.; Lipkind, Heather S.; Smith, Graeme N.

doi:10.1016/j.ajogmf.2022.100776

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…A high‐sensitivity CRP level represents heightened cardiovascular risk and predicts CVD‐associated mortality for patients. [ 203 , 204 ]…”

Section: Cardiovascular Monitoring and Treatment Options After Aismentioning

confidence: 99%

“…A high-sensitivity CRP level represents heightened cardiovascular risk and predicts CVD-associated mortality for patients. [203,204] While consensus guidelines are available to guide clinical treatment decisions, the evidence supporting many recommended interventions following AIS still requires improvement. In severe cases, ICU management for AIS patients consistently emphasizes optimizing systemic physiological homeostasis, neurological and hemodynamic monitoring, and managing intracranial complications after reperfusion therapies.…”

Section: Cardiovascular Monitoring and Treatment Options After Aismentioning

confidence: 99%

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Stroke Related Brain–Heart Crosstalk: Pathophysiology, Clinical Implications, and Underlying Mechanisms

Fan,

Cao,

et al. 2024

Advanced Science

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The emergence of acute ischemic stroke (AIS) induced cardiovascular dysfunctions as a bidirectional interaction has gained paramount importance in understanding the intricate relationship between the brain and heart. Post AIS, the ensuing cardiovascular dysfunctions encompass a spectrum of complications, including heart attack, congestive heart failure, systolic or diastolic dysfunction, arrhythmias, electrocardiographic anomalies, hemodynamic instability, cardiac arrest, among others, all of which are correlated with adverse outcomes and mortality. Mounting evidence underscores the intimate crosstalk between the heart and the brain, facilitated by intricate physiological and neurohumoral complex networks. The primary pathophysiological mechanisms contributing to these severe cardiac complications involve the hypothalamic‐pituitary‐adrenal (HPA) axis, sympathetic and parasympathetic hyperactivity, immune and inflammatory responses, and gut dysbiosis, collectively shaping the stroke‐related brain–heart axis. Ongoing research endeavors are concentrated on devising strategies to prevent AIS‐induced cardiovascular dysfunctions. Notably, labetalol, nicardipine, and nitroprusside are recommended for hypertension control, while β‐blockers are employed to avert chronic remodeling and address arrhythmias. However, despite these therapeutic interventions, therapeutic targets remain elusive, necessitating further investigations into this complex challenge. This review aims to delineate the state‐of‐the‐art pathophysiological mechanisms in AIS through preclinical and clinical research, unraveling their intricate interplay within the brain–heart axis, and offering pragmatic suggestions for managing AIS‐induced cardiovascular dysfunctions.

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“…A high‐sensitivity CRP level represents heightened cardiovascular risk and predicts CVD‐associated mortality for patients. [ 203 , 204 ]…”

Section: Cardiovascular Monitoring and Treatment Options After Aismentioning

confidence: 99%

Section: Cardiovascular Monitoring and Treatment Options After Aismentioning

confidence: 99%

Stroke Related Brain–Heart Crosstalk: Pathophysiology, Clinical Implications, and Underlying Mechanisms

Fan,

Cao,

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

“…Another study showed that hsCRP was elevated (median approx. 3 mg/L) in women with transient gestational hypertension, pre-eclampsia, or chronic hypertension with minor values’ differences amongst each group, therefore suggesting differences in the prevalence of metabolic syndrome after puerperium, whereas other data indicate that women with higher postpartum hsCRP (>3 mg/L) at 6–12 months post labor may possible have an increased CVD risk after hypersensitive pregnancy disorders [ 428 , 429 ]. CRP can be increased even decades post-eclamptic pregnancy, and even if ultra-high sensitive CRP (mean approx.…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

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Synergistic integration of deep learning with protein docking in cardiovascular disease treatment strategies

Yakoubi

2024

IUBMB Life

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This research delves into the exploration of the potential of tocopherol‐based nanoemulsion as a therapeutic agent for cardiovascular diseases (CVD) through an in‐depth molecular docking analysis. The study focuses on elucidating the molecular interactions between tocopherol and seven key proteins (1O8a, 4YAY, 4DLI, 1HW9, 2YCW, 1BO9 and 1CX2) that play pivotal roles in CVD development. Through rigorous in silico docking investigations, assessment was conducted on the binding affinities, inhibitory potentials and interaction patterns of tocopherol with these target proteins. The findings revealed significant interactions, particularly with 4YAY, displaying a robust binding energy of −6.39 kcal/mol and a promising Ki value of 20.84 μM. Notable interactions were also observed with 1HW9, 4DLI, 2YCW and 1CX2, further indicating tocopherol's potential therapeutic relevance. In contrast, no interaction was observed with 1BO9. Furthermore, an examination of the common residues of 4YAY bound to tocopherol was carried out, highlighting key intermolecular hydrophobic bonds that contribute to the interaction's stability. Tocopherol complies with pharmacokinetics (Lipinski's and Veber's) rules for oral bioavailability and proves safety non‐toxic and non‐carcinogenic. Thus, deep learning‐based protein language models ESM1‐b and ProtT5 were leveraged for input encodings to predict interaction sites between the 4YAY protein and tocopherol. Hence, highly accurate predictions of these critical protein–ligand interactions were achieved. This study not only advances the understanding of these interactions but also highlights deep learning's immense potential in molecular biology and drug discovery. It underscores tocopherol's promise as a cardiovascular disease management candidate, shedding light on its molecular interactions and compatibility with biomolecule‐like characteristics.

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High-sensitivity C-reactive protein use in cardiovascular risk screening at 6 to 12 months postpartum following hypertensive disorders of pregnancy

Cited by 3 publications

References 32 publications

Stroke Related Brain–Heart Crosstalk: Pathophysiology, Clinical Implications, and Underlying Mechanisms

Stroke Related Brain–Heart Crosstalk: Pathophysiology, Clinical Implications, and Underlying Mechanisms

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Synergistic integration of deep learning with protein docking in cardiovascular disease treatment strategies

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