High sensitivity C-reactive protein concentrations, birthweight and cardiovascular risk markers in Brazilian children

Rondó, Patrícia Helen de Carvalho; Pereira, Joilane Alves; Lemos, Jesuana Oliveira

doi:10.1038/ejcn.2013.75

Cited by 10 publications

(11 citation statements)

References 47 publications

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“…In other studies of Brazilian children aged 5-13 years, the authors observed a positive correlation between birth weight and the concentration of C-reactive protein, body mass index, waist circumference and skin folds. The authors suggested that higher birth weight predicted higher risk of overweight and obesity in childhood and higher risk of CVD in adulthood [22]. This was confirmed by a study of European children aged 2-9 years, in whom significant positive correlations between serum hsCRP and BMI and abdominal obesity rates were observed [14].…”

Section: Discussionmentioning

confidence: 86%

Insufficient physical activity increases cardiovascular risk in women with low birth mass

Czajkowska

Mazurek

Wiśniewski

et al. 2017

Biomedical Human Kinetics

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SummaryStudy aim: The aim of the study was to evaluate the relationship between low birth mass and concentration of high-sensitivity C-reactive protein (hsCRP) as a cardiovascular risk factor in young women with various levels of physical activity. Materials and methods: 102 female students aged 19.7 ± 0.8 (18.6-23.0) were included. The study group was divided according to the declared physical activity: high physical activity (HPA, n = 69) and low physical activity (LPA, n = 33). Anthropometric indices were measured: body mass, height, hip and waist circumference. hsCRP levels were obtained from venous blood samples. Birth body mass (BBM) and birth height were collected from medical documentation. Results: Women with low BBM and LPA had a significantly higher concentration of hsCRP than women with low BBM and HPA, as well as women with normal BBM. Conclusions: Low birth mass together with low physical activity is a strong predictor of raised concentration of hsCRP, which correlates with an increased risk of cardiovascular and metabolic diseases. Regular physical activity in women with low birth mass may prevent an increased hsCRP concentration, and as a result decrease the risk of cardiovascular and metabolic diseases.

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Section: Discussionmentioning

confidence: 86%

Insufficient physical activity increases cardiovascular risk in women with low birth mass

Czajkowska

Mazurek

Wiśniewski

et al. 2017

Biomedical Human Kinetics

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“…Lande et al in New York performed a cross-sectional study in children and adolescents aged 8-17 years and found that children with serum CRP level of ≥3 mg/L had a higher SBP compared to those with serum CRP level of ≤3 mg/L, while DBP did not significantly differ between the two groups [24]. A study by Rondo et al, in Brazil, was conducted in a total of 459 children aged 5-8 years and resulted in a significant positive correlation between hs-CRP level and systolic blood pressure (p � 0.03) [25]. e mechanisms on how CRP affects the vascular damage would be best attributed to angiogenesis, endothelial damage, oxidative stress, and vascular remodeling.…”

Section: Discussionmentioning

confidence: 97%

Association between High-Sensitivity C-Reactive Protein and Blood Pressure among Children with History of Low Birth Weight Appropriate for Gestational Age, Low Birth Weight Small for Gestational Age, and Normal Birth Weight in Manado, North Sulawesi

Umboh

Wilar

Umboh

et al. 2019

International Journal of Nephrology

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Over the past years, low birth weight (LBW) has been proven to be attributed to a wide variety of long-term morbidities, including hypertension. This study aimed to investigate the association between high-sensitivity C-reactive protein (hs-CRP) and blood pressure (BP) in children with a history of LBW appropriate for gestational age (LBW AGA), LBW small for gestational age (LBW SGA), and normal birth weight appropriate for gestational age (NBW AGA). The study cohort comprised children aged 9–12 years who were born in 2007–2010 at Prof. Dr. R. D. Kandou General Hospital Manado and resided in the city of Manado from March to August 2019. The children who met the inclusion criteria were evaluated for BP and hs-CRP level. A total of 120 children who met the inclusion criteria were enrolled in this study. Analysis for the association between LBW and NBW with systolic blood pressure (SBP) showed statistical significance (p=0.007). Linear regression analysis indicated a strongly significant influence of BW on serum hs-CRP level and SBP. Every 1 g increase in BW results in a decrease of serum hs-CRP level of 0.001 mg/L. Every 1 g increase in BW is attributed to 0.004 mmHg decrease in SBP. An increase in hs-CRP by 1 mg/L increases the SBP by 4.99 mmHg and DBP by 2.88 mmHg. LBW significantly correlates with hs-CRP level and higher SBP. A comprehensive education must be undertaken for the families who have children with LBW to reduce the risk of developing hypertension later in their life.

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“…26 hsCRP seviyelerinin de diğer faktörlerden bağımsız olarak hipertansif hastalarda yükseldiği gösterilmiştir. [27][28][29] Çalışmamızda hsCRP ve Lp(a) değerleri evre 2 hipertansiyonlu grupta anlamlı olarak daha yüksek bulundu. Tüm hasta grubunda inflamasyon parametreleri yüksek olan hastaların fonksiyonel olarak KVS değişikliklerinin diğer gruba göre daha fazla olduğu saptandı.…”

Section: Discussionunclassified

Is the Childhood Primary Hypertension Causes Target Organ Damage?

Şahan¹,

Sözeri²,

Devecí³

et al. 2016

Turkiye Klinikleri J Pediatr

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Ö ÖZ ZE ET T A Am ma aç ç: : Çocukluk çağında primer hipertansiyonun yüksek kardiyovasküler mortalite ve morbidite ile ilişkisi son yıllarda ciddi bir sağlık sorunu hâline gelmiş ve giderek önem kazanmıştır. Bu çalışmada, primer hipertansiyonlu çocuklarda geleneksel ve geleneksel olmayan risk faktörleri ve bu faktörlerin hedef organ hasarı üzerine etkisinin araştırılması amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Primer hipertansiyon tanısı alan 7-18 yaş arasındaki 50 hasta ile aynı yaş grubunda sağlıklı 100 kişi kontrol grubu olarak çalışmaya alındı. Hasta grubuna 24 saatlik yaşam içi kan basıncı ölçümü yapıldı. Biyokimyasal olarak kan lipitleri, hs CRP, Lp(a) bakıldı. Hedef organ tutulumu açısından retinopati, nefropati (24 saatlik idrarda mikroalbuminüri), kardiyopati (sol ventrikül hipertrofisi ve sol ventrikül kitle indeks) ve vaskülopati (karotis intima mediya kalın-lığı ve arteriyel katılık) değerlendirildi. B Bu ul lg gu ul la ar r: : Toplam 50 (35 erkek, 15 kız) hastada ortalama yaş 13,1±3,2 yıl, 100 (54 erkek, 46 kız) sağlıklı kontrolde 13,06±2,7 yıl idi. Hastaların 17 (%34)'sinde göz dibi etkilenmesi mevcuttu (14 (%28)'ünde evre 1, 3 (%6)'ünde evre 2 hipertansif retinopati). Bir (%2) hastada ekokardiyografik olarak sol ventrikül hipertrofisi görüldü. Sol ventrikül kitle indeksi 7 (%14) hastada yüksek saptandı (Ort: 28,32±11,43 g/m2,7). 26 (%52) hastada cIMT (sağda 0,468±0,062, solda 0,472±0,064 mm, kontrol grubunda sağda 0,406±0,041, solda 0,405±0,041; p=0,000), 18 (%36) hastada PWV (5,76±0,84 m/s, kontrol grubunda 5,30±0,70 m/s; p=0,000), 11 (%22) hastada santral augmentasyon indeksi (%10,54±6,56, kontrol grubunda %9,41±8,54; p=0,366) yüksek bulundu. Hastalığın şiddeti arttıkça mikroalbuminüri ve inflamasyon göstergelerinin anlamlı olarak arttığı, HDL değerlerinin düştüğü görüldü. Beyaz önlük hipertansiyonu saptanan 8 hastada değişik derecelerde hedef organ tutulumu saptandı. S So on nu uç ç: : Çocukluk çağında primer hipertansiyon, hedef organ hasarı yapması nedeni ile erken tanınması ve tedavi edilmesi gereken bir durumdur.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Hipertansiyon; organ; çocuk A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The primary hypertension in childhood that is related with high cardiovascular morbidity and mortality has been a serious health problem in recent years and has become more important. In this study, the exploration of the effects of traditional and nontraditional risk factors over target organ damage in children with primary hypertension is aimed. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : 50 patients who are between 7-18 years old and diagnosed as primary hypertension and 100 healthy children in the same age as a control group were evauated in study. Ambulatory blood pressure measurement within 24 hours was performed to the patient group. Biochemically, blood lipids, hs CRP, Lp(a) were measured. In terms of target organ involvement, retinopathy, nephropathy (microalbuminuria in 24-hour urine), car...

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High sensitivity C-reactive protein concentrations, birthweight and cardiovascular risk markers in Brazilian children

Cited by 10 publications

References 47 publications

Insufficient physical activity increases cardiovascular risk in women with low birth mass

Insufficient physical activity increases cardiovascular risk in women with low birth mass

Association between High-Sensitivity C-Reactive Protein and Blood Pressure among Children with History of Low Birth Weight Appropriate for Gestational Age, Low Birth Weight Small for Gestational Age, and Normal Birth Weight in Manado, North Sulawesi

Is the Childhood Primary Hypertension Causes Target Organ Damage?

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