High-Sensitivity C-Reactive Protein Complements Plasma Epstein-Barr Virus Deoxyribonucleic Acid Prognostication in Nasopharyngeal Carcinoma: A Large-Scale Retrospective and Prospective Cohort Study

Tang, Lin; Li, Chao Feng; Chen, Qiu Yan; Zhang, Lu; Lai, Xiaomin; He, Yun; Xu, Yun; Hu, Dong; Shi, Wen; Peng, Yu; Chen, Wen Hui; Liu, Huai; Guo, Shan; Liu, Li Ting; Li, Jing; Zhang, Jingping; Guo, Ling; Zhao, Chong; Cao, Ke; Qian, Chao Nan; Zeng, Yi Xin; Guo, Xiang; Zeng, Mu Sheng

doi:10.1016/j.ijrobp.2014.10.005

Cited by 37 publications

(27 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Full texts of these 16 remaining studies were assessed according to the inclusion and exclusion criteria, and 6 articles failed to offer sufficient prognostic information. Finally, as shown in Figure , a total of 10 studies comprising 7339 cases were included in this meta‐analysis . Patients were from different cancer centres and were assessed at different time points and differed in metastatic or non‐metastatic NPC.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic role of pre‐treatment serum albumin in patients with nasopharyngeal carcinoma: A meta‐analysis and systematic review

Yang

Wang

Liang

et al. 2019

Clinical Otolaryngology

View full text Add to dashboard Cite

Background Pre‐treatment serum albumin (ALB) is a novel index that was identified in recent years and is considered to be closely related to the prognosis of nasopharyngeal carcinoma (NPC). However, the association between ALB and NPC remains controversial. Objective of Review To assess the prognostic significance of pre‐treatment serum ALB in patients with NPC. Type of Review A systematic review and meta‐analysis. Search Strategy We searched PubMed, the Cochrane Library and the Web of Science for studies published up to August 2018. The keywords used were related to albumin, nasopharyngeal carcinoma and prognosis. Evaluation Method We extracted the following data from all included studies: author, publication year, country, cancer centre, time points of randomisation, sample size, mean or median age, gender, TNM stage of NPC, cut‐off value of pre‐treatment serum albumin, number of high‐grade cases and duration of follow‐up. Then, we generated the pooled hazard ratios (HR) for overall survival (OS) and distant metastasis‐free survival (DMFS) to perform this meta‐analysis. Results Ten studies comprising 7339 cases were included. Lower pre‐treatment serum ALB levels were significantly associated with worse OS (HR = 1.32, 95% CI 1.17‐1.48) and DMFS (HR = 1.40, 95% CI 1.08‐1.80). In general, our findings were further verified in the subgroup analyses based on three features, including cancer stage, cut‐off value and analysis type. Conclusion A decreased level of pre‐treatment serum albumin implies a poor prognosis and can be detected to define the risk stratification of NPC patients.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Finally, as shown in Figure 1, a total of 10 studies comprising 7339 cases were included in this meta-analysis. 20,21,[25][26][27][28][29][30][31][32] Patients were from different cancer centres and were assessed at different time points and differed in metastatic or non-metastatic NPC.…”

Section: Search Resultsmentioning

confidence: 99%

Prognostic role of pre‐treatment serum albumin in patients with nasopharyngeal carcinoma: A meta‐analysis and systematic review

Yang

Wang

Liang

et al. 2019

Clinical Otolaryngology

View full text Add to dashboard Cite

show abstract

“…Second, all the studies were from China. Among the 5 included studies, Tang was the author of 2 papers [ 27 , 28 ] and so was Xia. [ 29 , 30 ] Even though the studies pertained to a limited region, this largely reflects a greater research focus on the Chinese population owing to the vulnerability of Chinese people.…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of C-reactive protein in patients with nasopharyngeal carcinoma

Fang

et al. 2017

Medicine

View full text Add to dashboard Cite

Background:C-reactive protein (CRP) has been shown to be associated with several tumors. However, its association with nasopharyngeal carcinoma (NPC) is not well characterized. We performed a literature review and meta-analysis to assess the prognostic relevance of elevated CRP levels in patients with NPC.Methods:A literature search for relevant studies was performed on PubMed (Medline), the Cochrane Library, and Web of Science databases. Hazard ratios (95% confidence intervals) were calculated to assess the association between elevated CRP levels and survival outcomes.Results:Five studies with a combined study population of 5215 patients with NPC were included. Pooled hazard ratios for overall survival and distant metastasis-free survival were 1.84 (95% CI = 1.57–2.17) and 1.81 (95% CI = 1.53–2.14), respectively. Subgroup analyses showed that types of indicators and treatment before inclusion had no significant impact on the observed association.Conclusion:Elevated serum CRP levels in patients with NPC were associated with worse prognosis.

show abstract

“…It was reported that nonkeratinizing carcinoma was always associated with high plasma EBV DNA load that was related to poor prognosis. 35 – 37 However, we excluded EBV DNA load as a risk factor from the analysis because we only had less than 5% patients presenting with significant high EBV DNA load in this study. Therefore, there was less power to yield valuable outcomes in this situation.…”

Section: Disscussionmentioning

confidence: 99%

Prognostic Model of Death and Distant Metastasis for Nasopharyngeal Carcinoma Patients Receiving 3DCRT/IMRT in Nonendemic Area of China

Zang

Zhao

et al. 2016

Medicine

View full text Add to dashboard Cite

Few studies were conducted to explore the prognostic factors for nonendemic nasopharyngeal carcinoma (NPC) in the era of 3-dimensional conformal radiation therapy (3DCRT)/intensity-modulated radiation therapy (IMRT). The aim of this study was to evaluate the potential prognostic factors for nonendemic NPC.Between January 2004 and December 2011, a total of 393 nonendemic NPC patients receiving 3DCRT/IMRT were reviewed according to the inclusion and exclusion criteria. The prognostic factors we analyzed included age, T stage, N stage, lymph node diameter, primary tumor volume, WHO histology types, and cranial nerve related symptoms. All patients were staged according to the 7th edition of the American Joint Committee on Cancer (AJCC) system. The factors found to be associated with the endpoints by univariate analyses were then entered into multivariate Cox proportional hazards regression analysis.The median follow-up time was 61.4 months (range: 4–130 months). The 5-year local recurrent-free survival (LRFS), nodal relapse-free survival (NRFS), distant metastasis free survival (DMFS), and disease-specific survival (DSS) for all patients were 89.3%, 96.4%, 73.5%, and 74.3%, respectively. Multivariate analysis indicated that N stage (N2–3), WHO pathologic type II, and primary tumor volume (>23 mL) were 3 independent prognostic factors for DSS and DMFS. According to the number of prognostic factors, patients were divided into 3 risk groups: low-risk group (patients without any risk factors); intermediate-risk group (patients with only 1 risk factor); and high-risk group (patients with more than 2 risk factors). The 5-year DSS for low, intermediate, and high-risk groups were 91.5%, 75.2%, and 49.3%, respectively (P < 0.001). The 5-year DMFS for low, intermediate, and high-risk groups were 89.4%, 77.9%, and 49.4%, respectively (P < 0.001).Advanced N stage (N2–3), larger tumor volume (>23 mL), and histological WHO type II are independently prognostic factors for nonendemic NPC patients in China.

show abstract

High-Sensitivity C-Reactive Protein Complements Plasma Epstein-Barr Virus Deoxyribonucleic Acid Prognostication in Nasopharyngeal Carcinoma: A Large-Scale Retrospective and Prospective Cohort Study

Cited by 37 publications

References 24 publications

Prognostic role of pre‐treatment serum albumin in patients with nasopharyngeal carcinoma: A meta‐analysis and systematic review

Prognostic role of pre‐treatment serum albumin in patients with nasopharyngeal carcinoma: A meta‐analysis and systematic review

Prognostic role of C-reactive protein in patients with nasopharyngeal carcinoma

Prognostic Model of Death and Distant Metastasis for Nasopharyngeal Carcinoma Patients Receiving 3DCRT/IMRT in Nonendemic Area of China

Contact Info

Product

Resources

About