High sensitivity c-reactive protein as an independent risk factor for essential hypertension

Sung, Ki Chul; Suh, Jung Yul; Kim, Bum Soo; Kang, Jin Ho; Kim, Hyang; Lee, Man Ho; Park, Jung Ro; Kim, Sun Woo

doi:10.1016/s0895-7061(03)00566-1

Cited by 156 publications

(23 citation statements)

References 18 publications

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“…The median level of CRP in our study participants was higher than reported in other studies with Asian populations [27,33–37]. Ye et al reported that median CRP levels were 0.60 mg/dL in men and 0.88 mg/L in women with diabetes aged 50 to 70 years in Beijing and Shanghai [33].…”

Section: Discussioncontrasting

confidence: 76%

Association of obesity and biomarkers of inflammation and endothelial dysfunction in adults in Inner Mongolia, China

Thompson¹,

Zhang²,

Tong³

et al. 2011

International Journal of Cardiology

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Background Recent studies suggest that central obesity is an important predictor of cardiovascular disease (CVD) in addition to overall obesity. Both inflammation and endothelial dysfunction are associated with increased risk of CVD. We examined the association between body mass index (BMI) and waist circumference (WC) with plasma concentrations of biomarkers of inflammation and endothelial dysfunction. Methods We conducted a cross-sectional study of 2589 lean, moderately active participants aged 20 years and older in Inner Mongolia, China. Overnight fasting blood samples were obtained to measure the biomarkers including C-reactive protein (CRP), soluble inter-cellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin), and angiotensin II. Height, body weight, and WC were measured by trained staff and BMI was calculated (kg/m2). Results In univariate analysis, CRP, sICAM-1, and sE-selectin were all significantly higher among individuals with a higher BMI and WC. In multivariate analysis, each standard deviation (SD) increase in WC (9.6 cm) was associated with about 46% higher risk (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.21–1.76) of elevated CRP but a 1 SD increase in BMI (3.5 kg/m2) was not associated with the risk of elevated CRP (OR 0.96, 95% CI 0.80–1.16). However, each SD increase in BMI was associated with about 30% higher risk of having elevated E-selectin (OR 1.30, 95% CI 1.08–1.55). Conclusions WC is a stronger predictor of inflammation while BMI is a stronger predictor for endothelial dysfunction. These results suggest measuring both BMI and WC will help to assess the risk of CVD in the Chinese population.

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Section: Discussioncontrasting

confidence: 76%

Association of obesity and biomarkers of inflammation and endothelial dysfunction in adults in Inner Mongolia, China

Thompson¹,

Zhang²,

Tong³

et al. 2011

International Journal of Cardiology

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“…In 1984/1985, the Health and Lifestyle Survey (HALS-1), was conducted in a random sample of the Population of England, Scotland and Wales aged 18 and over. [ 18 , 19 ] This study was designed as a unique attempt to describe self-reported health, attitudes and beliefs about causes of disease in relation to measurements of health and lifestyle in adults. A total of 12 672 addresses were selected from the electoral rolls of 198 randomly selected constituencies.…”

Section: Methodsmentioning

confidence: 99%

“…[ 20 ] Ethical approvals were obtained from the British Medical Association ethical committee. [ 18 ] Each study participant gave its written informed consent.…”

Section: Methodsmentioning

confidence: 99%

Is the Relationship between Common Mental Disorder and Adiposity Bidirectional? Prospective Analyses of a UK General Population-Based Study

et al. 2015

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The direction of the association between mental health and adiposity is poorly understood. Our objective was to empirically examine this link in a UK study. This is a prospective cohort study of 3 388 people (men) aged ≥ 18 years at study induction who participated in both the UK Health and Lifestyle Survey at baseline (HALS-1, 1984/1985) and the re-survey (HALS-2, 1991/1992). At both survey examinations, body mass index, waist circumference and self-reported common mental disorder (the 30-item General Health Questionnaire, GHQ) were measured. Logistic regression models were used to compute odds ratios (OR) and accompanying 95% confidence intervals (CI) for the associations between (1) baseline common mental disorder (QHQ score > 4) and subsequent general and abdominal obesity and (2) baseline general and abdominal obesity and re-survey common mental disorders. After controlling for a range of covariates, participants with common mental disorder at baseline experienced greater odds of subsequently becoming overweight (women, OR: 1.30, 1.03 – 1.64; men, 1.05, 0.81 – 1.38) and obese (women, 1.26, 0.82 – 1.94; men, OR: 2.10, 1.23 – 3.55) than those who were free of common mental disorder. Similarly, having baseline common mental health disorder was also related to a greater risk of developing moderate (1.57, 1.21 – 2.04) and severe (1.48, 1.09 – 2.01) abdominal obesity (women only). Baseline general or abdominal obesity was not associated with the risk of future common mental disorder. These findings of the present study suggest that the direction of association between common mental disorders and adiposity is from common mental disorder to increased future risk of adiposity as opposed to the converse.

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“…Several studies have demonstrated higher plasma levels of CRP (Bautista et al, 2004; Stuveling et al, 2004; Sung et al, 2003), IL-6 (Bautista et al, 2005; Chae et al, 2001; Fernandez-Real et al, 2001), TNF-α (Bautista et al, 2005; Furumoto et al, 2002; Yu et al, 2010), and IL-1β (Dalekos et al, 1997; Zhao et al, 2004) in hypertensive patients compared to normotensive peers. The association between oxidative stress and hypertension is less substantiated but this could be partially due to challenges in measuring in vivo oxidative stress in humans.…”

Section: Common Mechanisms Of Aging and Hypertension – The Vasculamentioning

confidence: 99%

Hypertension and aging

Buford

2016

Ageing Research Reviews

381

289

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Hypertension is a highly prevalent condition with numerous health risks, and the incidence of hypertension is greatest among older adults. Traditional discussions of hypertension have largely focused on the risks for cardiovascular disease and associated events. However, there are a number of collateral effects, including risks for dementia, physical disability, and falls/fractures which are increasingly garnering attention in the hypertension literature. Several key mechanisms – including inflammation, oxidative stress, and endothelial dysfunction – are common to biologic aging and hypertension development and appear to have key mechanistic roles in the development of the cardiovascular and collateral risks of late-life hypertension. The objective of the present review is to highlight the multi-dimensional risks of hypertension among older adults and discuss potential strategies for treatment and future areas of research for improving overall care for older adults with hypertension.

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High sensitivity c-reactive protein as an independent risk factor for essential hypertension

Cited by 156 publications

References 18 publications

Association of obesity and biomarkers of inflammation and endothelial dysfunction in adults in Inner Mongolia, China

Association of obesity and biomarkers of inflammation and endothelial dysfunction in adults in Inner Mongolia, China

Is the Relationship between Common Mental Disorder and Adiposity Bidirectional? Prospective Analyses of a UK General Population-Based Study

Hypertension and aging

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