Association of obesity and biomarkers of inflammation and endothelial dysfunction in adults in Inner Mongolia, China

Abstract

Background Recent studies suggest that central obesity is an important predictor of cardiovascular disease (CVD) in addition to overall obesity. Both inflammation and endothelial dysfunction are associated with increased risk of CVD. We examined the association between body mass index (BMI) and waist circumference (WC) with plasma concentrations of biomarkers of inflammation and endothelial dysfunction. Methods We conducted a cross-sectional study of 2589 lean, moderately active participants aged 20 years and older in Inner Mongolia, China. Overnight fasting blood samples were obtained to measure the biomarkers including C-reactive protein (CRP), soluble inter-cellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin), and angiotensin II. Height, body weight, and WC were measured by trained staff and BMI was calculated (kg/m2). Results In univariate analysis, CRP, sICAM-1, and sE-selectin were all significantly higher among individuals with a higher BMI and WC. In multivariate analysis, each standard deviation (SD) increase in WC (9.6 cm) was associated with about 46% higher risk (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.21–1.76) of elevated CRP but a 1 SD increase in BMI (3.5 kg/m2) was not associated with the risk of elevated CRP (OR 0.96, 95% CI 0.80–1.16). However, each SD increase in BMI was associated with about 30% higher risk of having elevated E-selectin (OR 1.30, 95% CI 1.08–1.55). Conclusions WC is a stronger predictor of inflammation while BMI is a stronger predictor for endothelial dysfunction. These results suggest measuring both BMI and WC will help to assess the risk of CVD in the Chinese population.

Effects of Bariatric Surgery on Adipokine-Induced Inflammation and Insulin Resistance

“…Recent research has established that obesity is a chronic low-grade inflammatory condition (Herder et al, 2007; Liu et al, 2007; Amati et al, 2010; Balistreri et al, 2010; Park et al, 2010; Thompson et al, 2011). Following bariatric surgery, patients usually experience approximately 30% weight loss as well as decreased overall inflammatory responses (Compher and Badellino, 2008).…”

Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects

“…Many research studies indicate that obesity is a low-grade inflammatory condition [3, 4]. Expanded adipose tissue functions as an endocrine organ, which produces and secretes a number of hormones and cytokines known as adipokines [5, 6].…”

Altos niveles de adiposidad se asocian a un deterioro en la salud metabólica en adultos chilenos

“…La obesidad condiciona un estado inflamatorio a nivel sistémico que se manifiesta con el aumento de marcadores inflamatorios, como la PCRus y leptina 26,27 , cuyos niveles elevados se asocian con ECV y diabetes tipo 2 28,29,32 . En esta investigación, los tres indicadores de adiposidad mostraron una asociación positiva con los niveles de PCRus y leptina, resultados similares a los encontrados en otros estudios 30,31 .…”