High-Sensitivity C-Reactive Protein and Parameters of Left Ventricular Dysfunction

Beneficial Effects of Adaptive Servo Ventilation in Patients With Chronic Heart Failure

“…23 Serum CRP levels are associated with an increased risk of developing heart failure in elderly subjects 24 and are correlated with left ventricular remodeling and contractile dysfunction. 25 Proinflammatory cytokines appear to induce myocyte apoptosis and necrosis, 26 whereas CRP has adverse effects on vascular endothelium by reducing nitric oxide release and inducing the expression of endothelial adhesion molecules. 8 Furthermore, proinflammatory cytokines affect electrophysiological function and have an acute negative inotropic effect on cardiomyocytes.…”

Inflammation and C-Reactive Protein in Atrial Fibrillation: Cause or Effect?

“…These mechanisms lead to cellular membrane dysfunction, energy depletion, and apoptosis, 33 and might induce a low-grade inflammatory response-including healing and repair that bring about adverse structural and electrical changes and might also explain the significant difference in CRP levels during AF in the left atrium and coronary sinus. 14 In some cases, both the elevation of CRP and the onset of AF might be consequences of heart failure; indeed, Shah and colleagues 38 have shown, in 98 patients undergoing cardiac catheterization, that left ventricular end-diastolic pressure is closely associated with CRP level. On the other hand, heart failure is a recognized risk factor for AF.…”

Identification of clinical risk factors of atrial fibrillation in congestive heart failure

“…In the case of patients with CHF, this association remains unclear. Shah et al [16] demonstrated an association between serum hs-CRP and increasing LV end-diastolic pressure. Smith et al [17] showed that the occurrence of AF was independently associated with elevated MR--proANP and hs-CRP.…”