High-sensitivity C-reactive protein and high mobility group box-1 levels in Parkinson’s disease

Baran, Aslıhan; Bulut, Mahmut; Kaya, Mehmet Cemal; Demirpençe, Özlem; Sevim, Bunyamin; Akıl, Eşref; Varol, Sefer

doi:10.1007/s10072-018-3611-z

Cited by 22 publications

(24 citation statements)

References 27 publications

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“…In this case, the level of hsCRP in the peripheral blood may reflect the neuro-inflammatory status in the central nervous system. In the present study, we found a pronounced increase in the plasma level of hsCRP in PD patients compared to HC, which is in line with previous reports (Baran et al, 2019). Besides, in this present study, we found that plasma hsCRP level was negatively correlated with MoCA in PD, suggesting that elevated hsCRP level was associated with poor cognitive performance.…”

Section: Discussionsupporting

confidence: 93%

Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson’s Disease Severity

Yang

Chang

Que

et al. 2020

Front. Aging Neurosci.

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Aim: Oxidative stress and inflammation play critical roles in the neuropathogenesis of PD. We aimed to evaluate oxidative stress and inflammation status by measuring serum superoxide dismutase (SOD) with lipoprotein cholesterol and high-sensitivity C-reactive protein (hsCRP) respectively in PD patients, and explore their correlation with the disease severity. Methods: We performed a cross-sectional study that included 204 PD patients and 204 age-matched healthy controls (HCs). Plasma levels of SOD, hsCRP, total cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. A series of neuropsychological assessments were performed to rate the severity of PD. Results: The plasma levels of SOD (135.7 ± 20.14 vs. 147.2 ± 24.34, P < 0.0001), total cholesterol, HDL-C and LDL-C in PD were significantly lower than those in HCs; the hsCRP level was remarkably increased in PD compared to HC (2.766 ± 3.242 vs. 1.637 ± 1.597, P < 0.0001). The plasma SOD was negatively correlated with the hsCRP, while positively correlated with total cholesterol, HDL-C, and LDL-C in PD patients. The plasma SOD were negatively correlated with H&Y, total UPDRS, UPDRS (I), UPDRS (II), and UPDRS (III) scores, but positively correlated with MoCA and MMSE scores. Besides,

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Section: Discussionsupporting

confidence: 93%

Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson’s Disease Severity

Yang

Chang

Que

et al. 2020

Front. Aging Neurosci.

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“…Nineteen (15, 16, 21–35, 37, 38) studies recruited participants in Asian, three (18, 19, 36) in Europe and the remaining one (17) in South America. PD patients in nine researches (15, 17, 18, 24, 26, 32, 35–37) were taking anti-PD drugs such as levodopa. Eleven trials (18, 19, 24–29, 31, 33, 34) enrolled the PD patients accompanied by dementia, anxiety or depression.…”

Section: Resultsmentioning

confidence: 99%

“…Eleven trials (18, 19, 24–29, 31, 33, 34) enrolled the PD patients accompanied by dementia, anxiety or depression. Samples of 12 trials (16, 18, 21, 22, 25–28, 32–34, 37) were from serum, three (15, 24, 35) from plasma, four (17, 29–31) from the whole blood, three (19, 36, 38) from CSF, and one (23) from both blood and CSF. Thirteen studies (15, 16, 21, 22, 25–28, 30, 31, 33, 35, 37) applied high-sensitivity CRP (hs-CRP) assay and 10 (17–19, 23, 24, 29, 32, 34, 36, 38) utilized standard CRP maker.…”

Section: Resultsmentioning

confidence: 99%

“…The quality of the enrolled studies was assessed by means of Newcastle-Ottawa Scale. Ten (16, 17, 19, 21, 22, 24, 25, 29, 37, 38) out of 23 studies were assessed of high quality, 11 studies (18, 23, 26–28, 30, 31, 33–36) were assessed as medium quality, and the remaining two studies (15, 32) were evaluated as low quality.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty studies (15–18, 21–35, 37) measured CRP levels in peripheral blood consisting of those samples derived from serum, plasma or whole blood of PD patients. A total of 4,127 subjects with 2,360 PD patients and 1,767 normal controls were included in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

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C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis

Qiu

Xiao

et al. 2019

Front. Neurol.

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Background: C-reactive protein (CRP) has been identified as a common inflammation-related cytokine. Although publications indicate that CRP is associated with the pathogenesis of neurological disorders and deemed to be a “risk factor” for Parkinson's disease (PD), the evidence exists still indefinitely. Here, we performed a systematic review with meta-analysis synthesizing all the eligible studies on serum, plasma, and cerebrospinal fluid (CSF) CRP levels and PD risk to investigate the potential relevance. Methods: A systematical search up to October 2018 was performed via PubMed, Embase, Science Direct, ISI Web of Science as well as three Chinese medical databases: China National Knowledge Infrastructure database (CNKI), VIP database and WanFang database. Risk was assessed by standardized mean difference (SMD) with 95% confidence interval (CI) to investigate the involvement of CRP levels in PD patients. Results: Twenty-three eligible case-control studies involving 4,598 individuals (2,646 PD patients and 1,932 healthy controls) were incorporated into this meta-analysis. Results have indicated significant increase of CRP levels in PD subjects when compared with control groups in serum (SMD = 1.115, 95% CI 0.619–1.61, P < 0.001), CSF (SMD = 1.127, 95% CI 0.133–2.120, P = 0.026) as well as whole blood (SMD = 1.071, 95% CI 0.715–1.426, P < 0.001). Conclusions: This meta-analysis revealed that PD is associated with an increase of CRP levels. CRP might be a risk factor for PD or PD leads to an inflammatory response.

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Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease

et al. 2022

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High-sensitivity C-reactive protein and high mobility group box-1 levels in Parkinson’s disease

Cited by 22 publications

References 27 publications

Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson’s Disease Severity

Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson’s Disease Severity

C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis

Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease

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