Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease

Liu, Jie; Yin, Weifang; Zhou, Chen; Zhu, Yangfan; Gu, Meijuan; Liu, Bin; Ren, Hui; Yang, Xinglong

doi:10.1007/s40520-022-02134-8

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…In this case, the peripheral concentration of inflammatory protein can display the changes in the neuroinflammation of CNS. Previous literatures have shown that hs-CRP is increased in PD patients (34)(35)(36). Consistent with these studies, we also noted the increases in hs-CRP in PD patients when compared to the healthy control group.…”

Section: Comparison Of the Sensory And Motor Nerve Conduction Velocit...supporting

confidence: 92%

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

Zhang¹,

Liu²,

Li³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Section: Comparison Of the Sensory And Motor Nerve Conduction Velocit...supporting

confidence: 92%

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

Zhang¹,

Liu²,

Li³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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“…Furthermore, a meta-analysis found that Parkinson’s Disease (PD) is associated with an increase in CRP, which might be a risk factor for PD, and other data demonstrate that a higher baseline hsCRP may predict early idiopathic PD and poor prognosis—thus, subclinical systemic inflammations may accelerate neurodegeneration in PD—and, indeed, systemic inflammation in Lewy body diseases, particularly in PD, dementia is recorded. Additionally, it was concluded that hsCRP may even be a possible risk factor for PD, and a positive association between serum hsCRP levels and the freezing of gait has also been reported [ 584 , 585 , 586 , 587 , 588 , 589 , 590 , 591 ]. Furthermore, a meta-analysis correlated increased CRP levels with epilepsy, and elevated hsCRP has been recommended as a biomarker in idiopathic epilepsy.…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

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Utility of serum neurofilament light chain and glial fibrillary acidic protein as diagnostic biomarkers of freezing of gait in Parkinson’s disease

Liu,

Liu

et al. 2024

Brain Research

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Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease

Cited by 4 publications

References 48 publications

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Utility of serum neurofilament light chain and glial fibrillary acidic protein as diagnostic biomarkers of freezing of gait in Parkinson’s disease

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